DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and adamts13

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_002663267.4	Gene:	adamts13 / 100320289	ZFINID:	ZDB-GENE-070814-7	Length:	1498	Species:	Danio rerio

Alignment Length:	716	Identity:	154/716 - (21%)
Similarity:	236/716 - (32%)	Gaps:	227/716 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 QVAESRTRSR--------RQAPY---IIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLR 350
            |....|||.:        |::|.   :.|.|:.|:|..|.|.:|..|   .:||.::   .:::.
Zfish   191 QTLPVRTRLKQPKSQFRLRRSPLRSEVTYLELAVVVGPDVYEVHRQD---TERYILT---NLNIA 249

  Fly   351 YRLLK----GPRIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRL-PVY 410
            ..||:    |..||:.:..:||.  .:..|.::   :..:...|..::.:.|:.:..:... |::
Zfish   250 SELLRDVTLGANIRVHLVRMIIL--TEPEPDIQ---ISENITSSLKSVCEWGQKVNPDADSDPLH 309

  Fly   411 -DIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAH 474
             |:.:.||:.|:.....     |:...|....||.|..     :.|.| |.||||...||.: ||
Zfish   310 ADLLLYITRFDLVLPNG-----NKLVRGVTQFGGVCST-----QWNCV-ITEDTGFDLGITI-AH 362

  Fly   475 EVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIM-SDLRHTERGFRWSACTVQSFHHFLNGDTA 538
            |:||..|..|||..          ..|. ..|::| ||..:......||.|:....:.|.....|
Zfish   363 EIGHSFGINHDGID----------NTCS-SSGFMMASDGGYNSVDLTWSQCSRAQLYSFFRAGKA 416

  Fly   539 TCLHNAPHEDSALGRSL----PGTLLSLDAQCRRDRGT--YACF---KDERVCAQLFCFDAQTGY 594
            .|:.:.|    .||.|:    ||....:|.|||...|:  .||.   :|...|..|.|......:
Zfish   417 ECVQDVP----VLGGSVQDWRPGLFYGVDDQCRIAFGSSATACSFTNEDMTTCRVLSCHINPQDH 477

  Fly   595 CVAYR---PAAEGSACGNGYHCLDGRCTPLPSNIIPDYGHNYRLVYNKIDNKKDAAEDVESSSEE 656
            ....|   |..:|:.||....||.|||      :.|....:..:|:    ....|..|....|..
Zfish   478 SSCTRLLVPLLDGTECGPSQWCLKGRC------VSPSTSGSSMMVH----GSWSAWSDFSPCSRT 532

  Fly   657 TESQEDETESVEDQDEGTTSSEEQEDNKIEQSSAAGGAAAQSTTT------------------AR 703
            ...             |.|....|.:|   ..||.||...:...|                  ||
Zfish   533 CGG-------------GITHRRRQCNN---PRSAFGGTICKGQNTEAELCNLQLCDSTQLEFMAR 581

  Fly   704 STTTT-----TVRTTSTTTTTAKPK-SKSFGYLHRSLPERQWMQD-------------------- 742
            ..:.|     :|.|.|.:..|..|. |.|.|.....|..|...||
Zfish   582 QCSATDQQPLSVSTDSKSMYTWIPAISYSSGDSQCKLMCRSREQDFMVSRGSQFIDGTRCESDNP 646

  Fly   743 -------------------NGVLVTTRISS-------------SVSSSSSGSSSGEAAATSTRRP 775
                               :|.|.:.::..             .:|::.||..:|| ..|....|
Zfish   647 VPHGSISACLSGKCQLFGCDGALHSGKVEDVCGVCGGNGSTCHLISNTYSGGKAGE-YVTFLTLP 710

  Fly   776 TTTTTTQTPNLFQIYTH-------------------------ELRKQI---EYYL---HMLQTQQ 809
            ...:.....|...|:||                         .|.|.:   :.||   |:.||::
Zfish   711 LNASQVHVFNTRSIFTHLAVLLNDKYVVSGNGKPGLSNTYPSPLEKSLITYKLYLTPDHLPQTEE 775

  Fly   810 -----------HATKFQPEQQQ----------QQSQQQQSIVEIPLVQKSLTNYSVTSSSSSTSN 853
                       |...::...|:          .|......||||    .|...:|.|.|:.|.:.
Zfish   776 LYISGPVTDKIHLQVYRKYGQEYGDLTNPNISYQYYSDDVIVEI----ASKGKWSTTISACSVTC 836

  Fly   854 G 854
            |
Zfish   837 G 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	59/235 (25%)
adamts13	XP_002663267.4	Reprolysin	219..423	CDD:279729	59/237 (25%)
		ZnMc_ADAMTS_like	219..420	CDD:239801	59/234 (25%)
		TSP1	520..572	CDD:214559	12/67 (18%)
		TSP1	966..1023	CDD:214559
		TSP1	1154..1205	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910