DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and adamts12

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_021332071.1	Gene:	adamts12 / 100003937	ZFINID:	ZDB-GENE-070705-471	Length:	1500	Species:	Danio rerio

Alignment Length:	1367	Identity:	273/1367 - (19%)
Similarity:	441/1367 - (32%)	Gaps:	441/1367 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLFTALLLVSSTICQGL-PDLHKQMTPEQLQSVFHVDTHDAVPHYELVQLQHHENNHNRRRRSIG 69
            |||.|...|.|:....| ||..::...:| .|.|:||      |.|.|.               |
Zfish    15 VLFLAASHVKSSEPDYLFPDTEQEHFVKQ-HSEFYVD------HPEKVN---------------G 57

  Fly    70 KGPKVNAALPPHHV----KKDLS---KNAYYSELKHEALASGGNHLFAPEVSAIKSHNVSFSAFG 127
            :|..::.||..|..    |:||:   :..|| :|.:.                           |
Zfish    58 EGKFISYALSHHFTRRRQKRDLNSAERRVYY-KLNYR---------------------------G 94

  Fly   128 QHLNLSLRATQGLF-------KGAPHQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDE 185
            :.|.|:|.....|.       |........|...|:..:.|               .:|.|..|.
Zfish    95 RELTLNLTTNDNLLSNEFIVEKRNGSLAEKWPQSSDSGSCH---------------LIGTVTDDN 144

  Fly   186 KNMAAILMRRHMETGDL-IMEGSIGHDLVIKPLPHELSPNPEESHHIIYKREASAAEGQLSDFAF 249
            ....|.:.......|.| :.||    .|:|:|: ...|||.....|
Zfish   145 VQATAAISTCEGLRGLLNLPEG----PLLIEPV-RGRSPNLTHPQH------------------- 185

  Fly   250 MEPDDLLASEKLERLQRRQRRS---RRSAP-----SSPDFEDLNDEDEGALDGEPQVAESR---T 303
              |..|..|....|.  |||||   .:.:|     ||..|:.: ::|....:.|......|   .
Zfish   186 --PHVLYQSSTWSRF--RQRRSIDAHQQSPCGVKDSSGYFQQV-EQDRELWERESVDRNHRPDPE 245

  Fly   304 RSRRQAPYII----YPEVLVI-----VDYDGYRLHGGDNLQVKRYFISFWNGV-DLRYRLLKGPR 358
            |.||.:|..|    :.|.:|:     |||     ||..:  |:.|..:..|.| .:.:....|..
Zfish   246 RPRRISPRSISRERWVETMVVGDSKLVDY-----HGSGS--VESYIFTIMNMVAGIFHDASIGNA 303

  Fly   359 IRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRL-------PV-YDIAVA 415
            |.|.:..:|:..|.:.         |...|..|.  |.:..:...::.|       |. :|:|:.
Zfish   304 IHIVLVRLILLHGEEK---------GLKIIHHAD--TTLTSFCTWQKNLNPQSDTHPAHHDVAIL 357

  Fly   416 ITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVA---AHEVG 477
            ||:.|:|...:...|    |.|.:::.|.|..::      |..|.||    ||:.||   |||:|
Zfish   358 ITRKDVCAGMNQPCE----TLGLSHLSGMCQPHR------SCNINED----SGLPVAFTIAHELG 408

  Fly   478 HLLGAVHDGSPPPSYLGGPGAQRCRW--EDGYIMS-DLRHTERGFRWSACTVQSFHHFLNGDTAT 539
            |..|..|||.          ...|.:  :..:||| .|::......||:|:.:....||:.....
Zfish   409 HSFGIQHDGQ----------GNDCEFVGKQPFIMSRQLQYDSSPLTWSSCSKEYITRFLDRGWGF 463

  Fly   540 CLHNAPHE-DSALGRSLPGTLLSLDAQCRRDRGTYA--CFKDERVCAQLFCFDAQTGYCVAYRPA 601
            ||.:.|.: |.:...:.||...:...||:...|..|  |.:.|.||..|:|  :..|.|.:...:
Zfish   464 CLDDRPSKRDLSTPGAAPGVRYTPQHQCQLQYGPNATFCSEVENVCQILWC--SVNGSCRSKLDS 526

  Fly   602 -AEGSACGNGYHCLDGRCT---PLPSNI-------------------------------IPDYG- 630
             .:|:.||....|:.|.|.   .||..:                               .|::|
Zfish   527 PIDGTRCGPEKWCISGECVIVGKLPETVHGGWGPWSSWSHCSRTCGAGVQTADRECNQPKPEFGG 591

  Fly   631 -------HNYRLVYNKIDNKKDAAEDVESSSEETESQEDETESVEDQ------------------ 670
                   ..||:...|:..:|      ..|..|.:..|..|....::
Zfish   592 KYCTGERKRYRVCNTKLCVRK------HPSFREMQCSEFNTVPYHNELYQWIPVSSPSRPCELHC 650

  Fly   671 ---DEGTTSSEEQED----------NKIEQSSAAGGAAAQ------STTTARSTTTTTVRTTSTT 716
               ||  ..||:..|          |...::....|...:      ..:.|:..:........:|
Zfish   651 KPVDE--NFSEKMLDAVTDGTPCFMNNNSRNICVNGVCKEVGCDFGINSNAKEDSCGVCLGDGST 713

  Fly   717 TTTAKP---KSKSFGYLHRSLPER-------QWMQDNGVLVTTRISSSVSSSSSGSS----SGEA 767
            ..|.|.   :...|||:...|...       |.:::.|..:..|.|.|.....:|:.    :||.
Zfish   714 CETVKENFVEQDGFGYMDLVLIPAGARDIYIQEVEEAGNFLAMRASDSDEYYLNGNYIIQWNGEY 778

  Fly   768 AATSTR----------RPTTTTTTQTPNLFQIYTHELRKQIEYYLHMLQTQQHATK-FQPEQQQQ 821
            .|..|:          ..|:...|..|.:.|:...||...::|...:.:.:....: .:||...:
Zfish   779 EAGGTKFNYERSGNIENLTSAGPTTEPVMIQLLFQELNPGVKYEYTIKRRRPLGNEILEPEYIWK 843

  Fly   822 Q------------SQQQQSI----VEIPLVQKSLTNYSV------------------------TS 846
            .            .:|.|.:    .|:.:|:::|.:.|.                        |.
Zfish   844 HGAWTDCSTTCGLGEQHQPVRCFEPEVGVVEENLCDPSTRPDDKHRKCKSRDCPARWWVGGWQTC 908

  Fly   847 SSSSTSNGAKQQP-----------------------------PSNKD---ENQRQQQQQQQAQQQ 879
            ||:..|.|.|::.                             |.|:|   .::.......:..|.
Zfish   909 SSTCGSTGVKKRTILCVRTVAGEERVLHPGDCKQLLKPKPAVPCNRDVPCGSEWTVGNWSECSQS 973

  Fly   880 LQDGL-----------PDEENEAT-------AGIQSNEAIER------QKRKFPTTPTAATSAAQ 920
            ...|:           |...|.||       ..:||..:..|      :.||.||.|
Zfish   974 CDGGIKSRMVKCVAKQPSRCNPATRPRSTILCNLQSCSSTNRWTGPRFRPRKIPTQP-------- 1030

  Fly   921 KSATPATPATSATSARPT---PTTAKPITTSSFLDAYFKKLQALHDAG------SASSSTTTTTT 976
                   |.|..|...||   |.|:.||||.|...   .....:|:..      ..::....|.|
Zfish  1031 -------PGTQTTQYSPTITPPNTSTPITTQSNTS---PTSDIIHEDDKDFILVKKNNVAVPTIT 1085

  Fly   977 TSVSSSVSSATSSKQQHPQQQQQQQVQQIADGSHFLKRTPHR---SSLKAYKTSSSSSNNSSSQT 1038
            .....|.......|...|.....:..::|.:...|..: |..   ||::....|:..|....:.|
Zfish  1086 EDEEGSTDLQPPDKSYTPGYDYIEDPERIREDDLFTSK-PEEVLISSVQPITMSAPVSTTKPAIT 1149

  Fly  1039 QQQQQQQQQQYATNYIGDTT----NNQP-AVLDNSGSASS--TTETAK--KPKIKTQKLIRRTRV 1094
            ...:.|.....||:....|:    |:.| ..|.:..:.||  |..|.|  :..::|.|:..::.|
Zfish  1150 TTIRTQYDGHLATHACAKTSLYEFNSTPKPTLSHLNTLSSQVTVPTVKILRKALQTLKVPNKSNV 1214

  Fly  1095 MQ 1096
            ::
Zfish  1215 LK 1216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	62/252 (25%)
adamts12	XP_021332071.1	Pep_M12B_propep	51..190	CDD:307618	39/222 (18%)
		ZnMc_ADAMTS_like	259..466	CDD:239801	61/248 (25%)
		ADAM_CR	529..689	CDD:326582	25/167 (15%)
		TSP1	558..609	CDD:214559	5/50 (10%)
		ADAM_spacer1	715..825	CDD:310520	23/109 (21%)
		TSP1	960..1011	CDD:214559	8/50 (16%)
		TSP_1	1358..1401	CDD:326556
		TSP1	1404..1458	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810