Protein Alignment egl and EXD1

DIOPT Version :10

• Sequence 1: NP_726360.3
• Gene: egl / 37757
• FlyBaseID: FBgn0000562
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: NP_001273370.1
• Gene: EXD1 / 161829
• HGNCID: 28507
• Length: 572
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 118/548 - (21%)
• Similarity: 212/548 - (38%)
• Gaps: 132/548 - (24%)

  Fly   454 ENLEKDKQSLANQQGGPISPHASPVHSIANSSSNQNAGSAANNA-NSNSNANPNNANHSPSHSYF 517
            |.|::.:|.....:...:|.||...........:.|....|:.| .:.:.:..|:..:|||....
Human    69 ELLDEVEQGSVRAKASSVSLHAERTWMEKMKVEDLNVCEPASPAPEAPATSLLNDLKYSPSEEEE 133

  Fly   518 VGDTWKIKVLQNTTVIANVKQSVFVTDIILKYAAKNESIVVSLDCEGINLGLKGEITLIEIGTTR 582
            |           |..:.|..|..|.. .||....:|   |:|:..||.|:...|::..::: .|.
Human   134 V-----------TYTVINQFQQKFGA-AILHIKKQN---VLSVAAEGANVCRHGKLCWLQV-ATN 182

  Fly   583 GEAFLFDVQSCPAMVTDGGLKTVLEHDQVIKVIHDCRNDAANLYLQFGILLRNVFDTQAAHAILQ 647
            ...:|||:....:.....||:.:||..:::|||||||..:..|..|:||||.||||||.|..:..
Human   183 CRVYLFDIFLLGSRAFHNGLQMILEDKRILKVIHDCRWLSDCLSHQYGILLNNVFDTQVADVLQF 247

  Fly   648 YQESG---------------KQVYKA-KYISLNSLCEQYNAPCNPIKDQLKQIYRRDQKFWAKRP 696
            ..|:|               |.:..| ||:|              ..::.:::.:.:.:.|..||
Human   248 SMETGGYLPNCITTLQESLIKHLQVAPKYLS--------------FLEKRQKLIQENPEVWFIRP 298

  Fly   697 LTREMMLYAA------------------GDVLVLIHDQLFGNLARQIKPENRALFSELCTE--QI 741
            ::..::...|                  .|:..|:...|  |..|:...:........|.|  :.
Human   299 VSPSLLKILALEATYLLPLRLALLDEMMSDLTTLVDGYL--NTYREGSADRLGGTEPTCMELPEE 361

  Fly   742 LMQIKPNEVKIRKK-QRKVSTEVSDLKQKLAQTSKSIVLSNREIRLLRYMDLTEDEKERLKGY-- 803
            |:|:|..:.:.|:| .|:.......|..:.....|.:|..            |..::|::||:
Human   362 LLQLKDFQKQRREKAAREYRVNAQGLLIRTVLQPKKLVTE------------TAGKEEKVKGFLF 414

  Fly   804 ---YKV--AKKLEKMESAGNPSKDQSDSEDEQEPNENDAFPSLDSVPSDNSLSGTFSPRFSSEPP 863
               :::  |......:..|:.:..:.:|.::|..|.....|:.:...|::          ||...
Human   415 GKNFRIDKAPSFTSQDFHGDVNLLKEESLNKQATNPQHLPPTEEGETSED----------SSNKL 469

  Fly   864 SLTESMQMLEEILQNKSMDRIARIDKLEAILTTATSLPCEQIIASNSMQEQLGSSIATTENLQII 928
            ..|:|         ..|.|:  ||.:.|..:|     |..:..||.|::|:       ||.|.::
Human   470 ICTKS---------KGSEDQ--RITQKEHFMT-----PKHEFQASLSLKEE-------TEQLLMV 511

  Fly   929 REKSKNIKNCNCQG--------ERSVTP 948
             |..:::| |..|.        |..|:|
Human   512 -ENKEDLK-CTKQAVSMSSFPQETRVSP 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egl	NP_726360.3	Egl_like_exo	541..744	CDD:99851	57/238 (24%)
EXD1	NP_001273370.1	Egl_like_exo	147..345	CDD:99851	53/218 (24%)