DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sesn and sesn1

DIOPT Version :9

Sequence 1:	NP_001097437.1	Gene:	Sesn / 37755	FlyBaseID:	FBgn0034897	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_005160727.1	Gene:	sesn1 / 436933	ZFINID:	ZDB-GENE-040718-408	Length:	558	Species:	Danio rerio

Alignment Length:	492	Identity:	220/492 - (44%)
Similarity:	300/492 - (60%)	Gaps:	81/492 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ISQDCFAATQTGASDFDMDELDDLDQVTQVIGYHPQFHDHFLATQNFIMKGDGPLPNDYRYYLAI 78
            |.:|.||.            |..||.::.|:|:|||:.:.||.||:::::.||||....|:|:.|
Zfish   140 IFEDAFAV------------LGRLDNISLVMGFHPQYLESFLRTQHYLLQMDGPLSLHCRHYIGI 192

  Fly    79 IAAARHQCPYLVKRYEKEFINQGGDSAWLGGLDFIPAKLRAIYDINKILAHRPWLLRKEHIERLT 143
            :|||||||.|||..:..:|:..|||..||.||:..|.||:|:.::|||||||||||.|||||||.
Zfish   193 MAAARHQCTYLVNLHVNDFLQVGGDPKWLNGLEEAPRKLQALGELNKILAHRPWLLTKEHIERLL 257

  Fly   144 KG-KNSWSLSEVVHAMVLLSHFHSLSSFVFSCGLTQKLDGLSSPKLKSPPAAVAALAPTILITPT 207
            |. ::||||:|::||:|||:|:|||:||.|.||:|
Zfish   258 KAEEHSWSLAELIHAVVLLTHYHSLASFTFGCGIT------------------------------ 292

  Fly   208 SPTEPQKGKPVLAEISLNNANPDYDSQTAASSNGG---APPD-SANAVADGPDATTLNGYLATAQ 268
                                 ||      ..::||   .||. |...|.|..:.......:...|
Zfish   293 ---------------------PD------IHTDGGHTFRPPSLSGYCVCDIANGNGAQEDMFGNQ 330

  Fly   269 QLPQQHGISVETLMERMKVLSQKQD--ECSEAELSSRFQKVEQQTAELAAVTPEAAVGVPT-NLS 330
            |:.:..| .||.||||||.|.:.:|  |.|:.|:::||::  ::|..:..||.|....||: ::|
Zfish   331 QVSESSG-EVEVLMERMKQLQECRDEEEASQEEMATRFER--EKTECMLVVTSEDEECVPSRDVS 392

  Fly   331 HYVDDANFIYQDFARRGTESINTFRIQDYSWEDHGYSLVDGLYNDVGIFLDAKFRAAYNLTYCTM 395
            .:.:|.::.|:||:||| |.:.|.|:|||||||||:|||:.||:|.|..||.||:.|:||||.||
Zfish   393 RHFEDPSYGYKDFSRRG-EHVPTLRVQDYSWEDHGFSLVNRLYSDFGQLLDEKFQIAFNLTYNTM 456

  Fly   396 GGIKNVDTSKFRRAIWNYIQCIYGIRHDDYDYGEVNQLLVRPLKMFIKTACCFPERITTKDYDSV 460
            ...:.||||..||||||||.|::|||:|||||||:||||.|..|::|||..|.||:||.:.|:|.
Zfish   457 ATHQGVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTMVCSPEKITKRMYESF 521

  Fly   461 LVELQDSEKVHVNLMIMEARNQAELLYALREIMRYMT 497
            ..:.:.||||||||::||||.|||||||||.|.||||
Zfish   522 WRQFRHSEKVHVNLLLMEARMQAELLYALRAITRYMT 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sesn	NP_001097437.1	PA26	4..496	CDD:282488	217/489 (44%)
sesn1	XP_005160727.1	PA26	106..557	CDD:282488	217/489 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596795
Domainoid	1	1.000	385	1.000	Domainoid score	I774
eggNOG	1	0.900	-	-		E1_KOG3746
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1968
OMA	1	1.010	-	-		QHG55065
OrthoDB	1	1.010	-	-		D385556at33208
OrthoFinder	1	1.000	-	-		FOG0001796
OrthoInspector	1	1.000	-	-		otm25478
orthoMCL	1	0.900	-	-		OOG6_103913
Panther	1	1.100	-	-	O	PTHR12474
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4752
SonicParanoid	1	1.000	-	-		X1152
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800