Protein Alignment Sesn and SESN1

DIOPT Version :9

• Sequence 1: NP_001097437.1
• Gene: Sesn / 37755
• FlyBaseID: FBgn0034897
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_055269.1
• Gene: SESN1 / 27244
• HGNCID: 21595
• Length: 551
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 214/498 - (42%)
• Similarity: 296/498 - (59%)
• Gaps: 79/498 - (15%)

  Fly     9 ADMGQISQDCFAATQTGASDFDMDELDDLDQVTQVIGYHPQFHDHFLATQNFIMKGDGPLPNDYR 73
            |.|..:..|.|||            |..||.:|.|:.:|||:.:.||.||:::::.|||||..||
Human   124 AQMHALFADSFAA------------LGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYR 176

  Fly    74 YYLAIIAAARHQCPYLVKRYEKEFINQGGDSAWLGGLDFIPAKLRAIYDINKILAHRPWLLRKEH 138
            :|:.|:|||||||.|||..:..:|::.|||..||.||:..|.||:.:.::||:|||||||:.|||
Human   177 HYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEH 241

  Fly   139 IERLTKG-KNSWSLSEVVHAMVLLSHFHSLSSFVFSCGLTQKLDGLSSPKLKSPPAAVAALAPTI 202
            ||.|.|. ::||||:|:|||:|||:|:|||:||.|.||::.::........:.|..:...:.
Human   242 IEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCIC--- 303

  Fly   203 LITPTSPTEPQKGKPVLAEISLNNANPDYDSQTAASSNGGAPPDSANAVADGPDATTLNGYLATA 267
                                .:.|.|...|.....|:...:..||.
Human   304 --------------------DITNGNHSVDEMPVNSAENVSVSDSF------------------- 329

  Fly   268 QQLPQQHGISVETLMERMKVLSQKQD--ECSEAELSSRFQKVEQQ------TAELAAVTPEAAVG 324
                    ..||.|||:|:.|.:.:|  |.|:.|::|||: :|::      :::...|||..||
Human   330 --------FEVEALMEKMRQLQECRDEEEASQEEMASRFE-IEKRESMFVFSSDDEEVTPARAV- 384

  Fly   325 VPTNLSHYVDDANFIYQDFARRGTESINTFRIQDYSWEDHGYSLVDGLYNDVGIFLDAKFRAAYN 389
                 |.:.:|.::.|:||:|.|.. :.|||:|||.|||||||||:.||.|||..:|.||..|||
Human   385 -----SRHFEDTSYGYKDFSRHGMH-VPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYN 443

  Fly   390 LTYCTMGGIKNVDTSKFRRAIWNYIQCIYGIRHDDYDYGEVNQLLVRPLKMFIKTACCFPERITT 454
            |||.||...|:||||..||||||||.|::|||:|||||||:||||.|..|::|||..|.||::|.
Human   444 LTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTK 508

  Fly   455 KDYDSVLVELQDSEKVHVNLMIMEARNQAELLYALREIMRYMT 497
            :.|||...:.:.||||||||:::|||.|||||||||.|.||||
Human   509 RMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sesn	NP_001097437.1	PA26	4..496	CDD:282488	211/495 (43%)
SESN1	NP_055269.1	PA26	106..550	CDD:282488	211/495 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160418
Domainoid	1	1.000	383	1.000	Domainoid score	I826
eggNOG	1	0.900	-	-		E1_KOG3746
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	384	1.000	Inparanoid score	I2047
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55065
OrthoDB	1	1.010	-	-		D385556at33208
OrthoFinder	1	1.000	-	-		FOG0001796
OrthoInspector	1	1.000	-	-		otm41093
orthoMCL	1	0.900	-	-		OOG6_103913
Panther	1	1.100	-	-	O	PTHR12474
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4752
SonicParanoid	1	1.000	-	-		X1152
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800