DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sesn and SESN3

DIOPT Version :9

Sequence 1:	NP_001097437.1	Gene:	Sesn / 37755	FlyBaseID:	FBgn0034897	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_653266.2	Gene:	SESN3 / 143686	HGNCID:	23060	Length:	492	Species:	Homo sapiens

Alignment Length:	481	Identity:	209/481 - (43%)
Similarity:	296/481 - (61%)	Gaps:	80/481 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LDQVTQVIGYHPQFHDHFLATQNFIMKGDGPLPNDYRYYLAIIAAARHQCPYLVKRYEKEFINQG 101
            ||.:|||:..|.|:.:.||.:|.::::.|||||..||:|:||:|||||||.||:..:..||:..|
Human    72 LDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTG 136

  Fly   102 GDSAWLGGLDFIPAKLRAIYDINKILAHRPWLLRKEHIERLTK-GKNSWSLSEVVHAMVLLSHFH 165
            |.:.||.||:::|.:|:.:.:|||:|||||||:.||||::|.| |:|:|||.|:|||:|||:|:|
Human   137 GIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYH 201

  Fly   166 SLSSFVFSCGLTQKLDGLSSPKLKSPPAAVAALAPTILITPTSPTEPQKGKPVLAEISLNN---- 226
            :|:||||..|                            |.|....|...|   ...||:||
Human   202 ALASFVFGSG----------------------------INPERDPEISNG---FRLISVNNFCVC 235

  Fly   227 --ANPDYDSQTAASSNGGAPPDSANAVADGPDATTLNGYLATAQQLPQQHGISVETLMERMKVLS 289
              ||.:.....:.|.:.....||.:                           .:|.||||||.|.
Human   236 DLANDNNIENASLSGSNFGIVDSLS---------------------------ELEALMERMKRLQ 273

  Fly   290 QKQ--DECSEAELSSRFQKVEQQTAELAAVTPEAAVGVP-----------TNLSHYVDDANFIYQ 341
            :::  :|.|:.|:|:||:|.::::  |..|:.:.....|           :::|.|::|..|.|:
Human   274 EEREDEEASQEEMSTRFEKEKKES--LFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYE 336

  Fly   342 DFARRGTESINTFRIQDYSWEDHGYSLVDGLYNDVGIFLDAKFRAAYNLTYCTMGGIKNVDTSKF 406
            ||||||.|.:.|||.|||:||:||:|||:.||:|:|..||.|||..|||||.||...::|||:..
Human   337 DFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTML 401

  Fly   407 RRAIWNYIQCIYGIRHDDYDYGEVNQLLVRPLKMFIKTACCFPERITTKDYDSVLVELQDSEKVH 471
            |||::||:.|::|||:||||||||||||.|.||::|||..|:|||.|.:.|||...:.:.|||||
Human   402 RRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVH 466

  Fly   472 VNLMIMEARNQAELLYALREIMRYMT 497
            |||::||||.|||||||||.|.|::|
Human   467 VNLLLMEARMQAELLYALRAITRHLT 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sesn	NP_001097437.1	PA26	4..496	CDD:282488	208/478 (44%)
SESN3	NP_653266.2	PA26	39..490	CDD:282488	207/477 (43%)
		C-terminal domain, mediates TORC1 regulation. /evidence=ECO:0000250\|UniProtKB:P58004	310..492		103/181 (57%)
		Leucine-binding. /evidence=ECO:0000250\|UniProtKB:P58004	386..389		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160417
Domainoid	1	1.000	383	1.000	Domainoid score	I826
eggNOG	1	0.900	-	-		E1_KOG3746
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14386
Inparanoid	1	1.050	384	1.000	Inparanoid score	I2047
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55065
OrthoDB	1	1.010	-	-		D385556at33208
OrthoFinder	1	1.000	-	-		FOG0001796
OrthoInspector	1	1.000	-	-		otm41093
orthoMCL	1	0.900	-	-		OOG6_103913
Panther	1	1.100	-	-	O	PTHR12474
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4752
SonicParanoid	1	1.000	-	-		X1152
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800