DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg3 and ALG3

DIOPT Version :9

Sequence 1:	NP_523829.2	Gene:	Alg3 / 37754	FlyBaseID:	FBgn0011297	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_009471.1	Gene:	ALG3 / 852196	SGDID:	S000000178	Length:	458	Species:	Saccharomyces cerevisiae

Alignment Length:	510	Identity:	155/510 - (30%)
Similarity:	237/510 - (46%)	Gaps:	122/510 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KYLLLEPAALPIVGLFVLLAELVINVVVIQRVPYTEIDWVAYMQECEGF-LNGTTNYSLLRGDTG 99
            :|::.:..|..||...::|.|.::..::|::|.|||||:.|||::.|.. |:|..:||.:.|.||
Yeast    34 RYVIFDCRANLIVMPLLILFESMLCKIIIKKVAYTEIDYKAYMEQIEMIQLDGMLDYSQVSGGTG 98

  Fly   100 PLVYPAAFVYIYSALYYVTSHGTNVRLAQYIFAGIYLLQLALVLRLYSKSRKVPPYVLVLSAFTS 164
            ||||||..|.||..:|::|....:|...|..|..:|||.|||.:..|.... :||:.:|| |..|
Yeast    99 PLVYPAGHVLIYKMMYWLTEGMDHVERGQVFFRYLYLLTLALQMACYYLLH-LPPWCVVL-ACLS 161

  Fly   165 YRIHSIYVLRLFNDPVAVLLLYAALNLFLDRRWTLG---------------------STFFSLAV 208
            .|:|||||||||||....|.:...:         ||                     |..:|:||
Yeast   162 KRLHSIYVLRLFNDCFTTLFMVVTV---------LGAIVASRCHQRPKLKKSLALVISATYSMAV 217

  Fly   209 GVKMNILLFAPALL--LFYLANLGLLRTILQLAVCGVIQLLLGAPFLLTHPVEYLRGSFDLGRIF 271
            .:|||.||:.||::  ||.|.:..::.|:|.|......|:.:..|||.:.|.:||..:|:.||.|
Yeast   218 SIKMNALLYFPAMMISLFILNDANVILTLLDLVAMIAWQVAVAVPFLRSFPQQYLHCAFNFGRKF 282

  Fly   272 EHKWTVNYRFLSRDLFENRTFHVSLLGLHLLLLLAFAKPTWTFFQSYVRLRRIEDQLQPQI---- 332
            .::|::|::.:..:.|.::.||::||..||:.|      |..|...|.|       :.|.:
Yeast   283 MYQWSINWQMMDEEAFNDKRFHLALLISHLIAL------TTLFVTRYPR-------ILPDLWSSL 334

  Fly   333 ---AQQNLELNAQKRPKKVEKDKDKDQKKFTTEQQSFLKAFEKSLQKASGGKATPAPAQAEPERY 394
               .::|..|||.                                           ||:.
Yeast   335 CHPLRKNAVLNAN-------------------------------------------PAKT----- 351

  Fly   395 GIHFDRCTQLALLPFFL--CNLVGVACSRSLHYQFYVWYFHSLPYLA-WS-TPYSLGVRCLILGL 455
                        :||.|  .|.:||..||||||||..||..:||.|. || .|:.:|....:|.
Yeast   352 ------------IPFVLIASNFIGVLFSRSLHYQFLSWYHWTLPILIFWSGMPFFVGPIWYVLH- 403

  Fly   456 IEYCWNTY-PSTNFSSAALHFTHIILLAGVAKQLVQTMRINNAAKREQQEQQKKL 509
             |:|||:| |::..|:..|....::||.....||..::.:..:..|.....:|||
Yeast   404 -EWCWNSYPPNSQASTLLLALNTVLLLLLALTQLSGSVALAKSHLRTTSSMEKKL 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg3	NP_523829.2	ALG3	51..470	CDD:282992	141/454 (31%)
ALG3	NP_009471.1	ALG3	48..417	CDD:398745	141/454 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346262
Domainoid	1	1.000	220	1.000	Domainoid score	I455
eggNOG	1	0.900	-	-		E1_KOG2762
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4228
Inparanoid	1	1.050	230	1.000	Inparanoid score	I731
Isobase	1	0.950	-	0	Normalized mean entropy	S1761
OMA	1	1.010	-	-		QHG53696
OrthoFinder	1	1.000	-	-		FOG0004953
OrthoInspector	1	1.000	-	-		oto99887
orthoMCL	1	0.900	-	-		OOG6_103036
Panther	1	1.100	-	-	LDO	PTHR12646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R42
SonicParanoid	1	1.000	-	-		X3495
TreeFam	1	0.960	-	-
	16	15.740