DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30183 and Anln

DIOPT Version :9

Sequence 1:	NP_001137745.2	Gene:	CG30183 / 37749	FlyBaseID:	FBgn0050183	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_006510644.1	Gene:	Anln / 68743	MGIID:	1920174	Length:	1139	Species:	Mus musculus

Alignment Length:	1350	Identity:	278/1350 - (20%)
Similarity:	456/1350 - (33%)	Gaps:	368/1350 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 EAERVLDEFLRKRGVQVPTSKLEPSLKKDSKRRSFPMAEVEKPRHPRSNKQLPTC--PSLSDIER 400
            |..|...|.|:::..:.||:....:  ..:||...|::|....:.|....:..:|  ||.|
Mouse    10 ERTRARRENLQRKMAERPTAVARSA--PHAKRGREPLSEASNQQQPLPGGEEKSCTKPSPS---- 68

  Fly   401 VVESKRGSNYDRNIRQESRRKGAPTKEVILGWTEPKITDMLNYEGKTASEFRTPAEPQVAIGWQM 465
               .||.|        :....|||..|.    |||             .:...|..|..|
Mouse    69 ---KKRCS--------DKIEVGAPDLEN----TEP-------------IDVAKPCSPMPA----- 100

  Fly   466 PKAQPQPVVPKVSLDTVDGSVSENLASNMVHKETPIKYPSRVNTAGGQAS---------QKFIWS 521
            |: |.:|..|        .::||::|:     ...:....|...:|.:||         |:.  :
Mouse   101 PR-QAKPPAP--------AAISESVAA-----PAALLSADRGLNSGSEASATSSVKTRMQRL--A 149

  Fly   522 EQWRNLSPWKGNKPKNLGKKSKNFLNNSKKKILRFVSPKKSNQEVHTQLDQHRFTPQQCTI---- 582
            ||.|:   |..:...::.:.|......::.|......|..||........:.|......||
Mouse   150 EQRRH---WDSDLTDDVSESSYFAPVPTEDKAASPSKPPISNASATPVGRRGRLANLAATICSWE 211

  Fly   583 --GVQTSTSQLDLQSQSPPGSYHSPMQTTPSGTTTSTRQQLDTEQPYFDFERKVKAPTPPKKLPR 645
              ...:|..|..:|.|  ||:......::.||.:.|.......::......|...|..  :|.|.
Mouse   212 DDVSHSSAKQNSVQEQ--PGTACLSKSSSASGASASINSSSVQQEATCCSPRDGNASV--RKDPS 272

  Fly   646 ANRARKLDFQAAATSPTTYRSYHKDLDQDVTITKMGYLLS-SIRAKLEASDEHAVRTFQDCSRFD 709
            :|.|.                              |.||| |:.:.::||......||...:| :
Mouse   273 SNAAH------------------------------GPLLSASVSSSVKASSPVTAATFITENR-E 306

  Fly   710 RHEPQISH-----LQTESYDCTDGP--SSGATTSLATTRQQRDFDSEPIYSEIEEDCLRIRGSPH 767
            ...|::.|     |:||:....:.|  |.||               :|......|.||:
Mouse   307 AQNPELLHKTASPLKTEARKPCEKPTLSQGA---------------QPKEEANREVCLQ------ 350

  Fly   768 HEVRTAAQIIDHTPTPTESSTAYVSGSVPAPSTSR--------DDISAMYARVQKTPKNSPQMKP 824
                  :|..|...||        .|....|...|        ...|..|....|||..:|..|.
Mouse   351 ------SQSKDKLATP--------GGRGIKPFLERFGERCQEHSKESPSYRASHKTPNITPNTKA 401

  Fly   825 VDKPQISFQAIQPQKSTHSFSPPITTHIVLDQAVQPK----SC------------TQSNPAQLST 873
            :.      :.:..|.:..|     |||:. .|..|.:    :|            .:.|....|.
Mouse   402 IQ------ERLFKQNTCSS-----TTHLA-QQLKQEREKELACLRGRLDKGNLWSAEKNEKSRSK 454

  Fly   874 QMVSPQSTAPQQPVALGHFLHESLKNGNFFQFMPL--------PEEPSGTESSCSASQTTESSVI 930
            .:.:.|..         |..:..||........||        ..||:...||...:.:|||.:.
Mouse   455 HLETKQEV---------HCQNTPLKKHQTVASTPLTSVTDKVAENEPAVKLSSTEPAGSTESEMT 510

  Fly   931 RQPKLKLP-SPHAHQSLNNIS----EQHSPPKQNRNLSRSELSLQRS----EIFLDNLCRSELVL 986
            :...||:. .....:||...|    ||::...:...:|..:..:..|    :||.|.|...||.:
Mouse   511 KSSPLKITLFLEEEKSLKVASDLEVEQNTEAVREVEMSVDDEDINSSRVINDIFSDVLEEGELDV 575

  Fly   987 DRPEKVPNNTSNMDSVSYDMPEQLYADYSLVGAGSAGSSFVTNDYGSGQIEPEPANQSTPKKKQS 1051
            ::.::      .||.|..:..|:.....::    |:.|.........|.:..|....|.|.
Mouse   576 EKSQE------EMDQVGAENSEEQEDALNI----SSMSLLAPLAQTVGVVSLENVISSPPS---- 626

  Fly  1052 QRFTTKPASNLTIEINDGQATSLRHFGNNLSISCPTTPQQAQASQAVDPTVLHNSSSLGELMQTM 1116
                         |:.|          :|||.:.| .|.:.|.::.  |.. .::.|||.
Mouse   627 -------------ELRD----------SNLSAASP-KPGKFQRTRV--PRA-ESADSLGS----- 659

  Fly  1117 PNPSDSQLM-SVSALARYRLLKNALRRSYRKGKDFFLAEKQRLAQSLNLSRDQSNQTDGELDSST 1180
               .|..|: |:.|. |.:..|...|.|.::    .:..|:.:...|.   ::.|...|:::...
Mouse   660 ---EDRDLLYSIDAY-RSQRFKETERPSIKQ----VIVRKEDVTSKLG---EKKNVFSGQVNIKQ 713

  Fly  1181 YYANFNVDSLLNDSLNPNEQLAQAVSICRQMPTLEISAEMVEAERLLLFSTLRKSTPPVCQLND- 1244
            .....|.|..|..::  ..|.:||::.|......:.|.|..|||||||.:| .|....:.:||.
Mouse   714 KMQELNNDINLQQTV--IYQASQALNCCVDEEHGKGSLEEAEAERLLLIAT-EKRALLIDELNKL 775

  Fly  1245 EALAARRKSQCLLIDAME--------------LPVRAD-----VSRDMFFNYHYICTFECGGR-- 1288
            ::...:|:::..:|...|              ||::||     ..:....||:|:...:.|..
Mouse   776 KSEGPQRRNKTSVISQSEFAPSKGSVTLSEICLPLKADFVCSTAQKTDASNYYYLIMLKAGAEQM 840

  Fly  1289 ----IRSTQSVECQNGSAFFRDCGLEFYSGENADSLELRCQIFMLRLRKVS-----------TLA 1338
                :.||.:....:...|    ...|...:.::..|:..:::.|..:|.|           :.|
Mouse   841 VATPLASTANSLSGDALTF----PTTFTLHDVSNDFEINIEVYSLVQKKDSLGPDKKKKASKSKA 901

  Fly  1339 LEPAKSLRRGSGNLGSANSSCSAGSGGEQIMSRFRLHASFHLRAVDLSPFQLVSNESRS------ 1397
            :.| |.|.....:..|.:||..|..||              |.||..|.|.||.:.:.|
Mouse   902 ITP-KRLLTSITSKSSLHSSVMASPGG--------------LGAVRTSNFTLVGSHTLSLSSVGD 951

  Fly  1398 ----SDKICLRSSRSWQVPLTTHTKSTNLGPAISITGRVDLRL-----PKTRFSGYLNV-QDPKS 1452
                .|||.........:......|...|.|   :.|.:.|::     ......|:|.: :|...
Mouse   952 TKFALDKINFDVREQELLGYLFQEKVPFLSP---LEGHICLKISCQVNSAVEEKGFLTIFEDVSG 1013

  Fly  1453 QHNWNRRWCSLDGVRLSVWQHEDNLESDIPIFTLELPGLGQSLIAAAPRELCARARSFLL----- 1512
            ...|:||||.|.|..:|.|.:.|:.....||..:.|.......|..|.||.|||..:..|
Mouse  1014 FGAWHRRWCVLSGNCISYWTYPDDERRKNPIGRINLANCISHQIEPANREFCARRNTLELITVRP 1078

  Fly  1513 -----------QGRNSDCESGRVFFAADTQAELSEWLIHLNEAIAFARHW 1551
                       |.|::.|.: :.:.:|||:.|...|:..||:.|...|.|
Mouse  1079 QREDDRETLVSQCRDTLCVT-KNWLSADTKEERDLWMQKLNQVIVDIRLW 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30183	NP_001137745.2	PH_anillin	1438..1549	CDD:269964	35/127 (28%)
CG30183	NP_001137745.2	PH	1442..1546	CDD:278594	34/120 (28%)
Anln	XP_006510644.1	PHA03307	24..>206	CDD:223039	46/239 (19%)
		Anillin_N	141..227	CDD:374301	16/90 (18%)
		Anillin_N	423..488	CDD:374301	10/73 (14%)
		Anillin	797..950	CDD:369734	34/171 (20%)
		PH_anillin	999..1125	CDD:269964	35/126 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837706
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3640
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003560
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21538
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840