DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30183 and mid1

DIOPT Version :9

Sequence 1:	NP_001137745.2	Gene:	CG30183 / 37749	FlyBaseID:	FBgn0050183	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_588075.1	Gene:	mid1 / 2539205	PomBaseID:	SPCC4B3.15	Length:	920	Species:	Schizosaccharomyces pombe

Alignment Length:	937	Identity:	184/937 - (19%)
Similarity:	304/937 - (32%)	Gaps:	318/937 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 VHKETPIKYPSRVNTAGGQASQKFIWSEQWRNLSPWKG----------NKPKNLGKKSKNFLNNS 549
            ::.|...:.||...:||...|..       .:.:..||          |..:||.:.|.:...:|
pombe   117 INSEEEGRIPSLTYSAGTMNSTS-------SSTASLKGADIVADYETFNPDQNLAELSFDRSKSS 174

  Fly   550 KKKILRFVSPKKSNQEVHTQLDQHRFTPQQCTIGVQTSTSQLDLQSQSPPGSYHSPMQTTPSGTT 614
            :|:.:......::.                       :.|.|:...|.|..| |:.:.|.|:...
pombe   175 RKRAVEVAEFSRAK-----------------------TMSPLEYTVQHPYQS-HNELSTNPARAR 215

  Fly   615 TSTRQQLDTEQPYFDFERKVKAPTPPKKLPRANRARKLDFQAAAT-SPTTYRSYHKDLDQDVTIT 678
            ..:...|            .:.|:..|.:|.|:      ..|::| .|....|..||..:|....
pombe   216 AGSVPNL------------ARIPSDVKPVPPAH------LSASSTVGPRILPSLPKDTTEDNPAL 262

  Fly   679 KMGYLLSSIRAKLEASDEHAVRTFQDCSRFDRHEP---------QISHLQTESY----------- 723
            :.....:|:  .::......:...|:....|..||         ..|.:.|||.
pombe   263 ERVETTASL--DMDYKPLEPLAPIQEAPVEDTSEPFSSVPEATLDDSDISTESLRKKVLAKMEAK 325

  Fly   724 DCTDGPSSGAT-------TSLATTRQQRDFD---------SEPIYSEIEEDCLRIRGSPHHEVRT 772
            ..:.|.|..:|       :.|:.....:|:|         |||..|.|..|.|        :...
pombe   326 RISSGSSYASTLRKVYDFSELSLPTNGKDYDELYLQSSRNSEPEISTIINDSL--------QQEN 382

  Fly   773 AAQIIDHTPTPTESSTAYVSGSVP-------------------------APSTSRDDISAMYARV 812
            ..:.|..|..| :|..||..|||.                         ..|::.|::||:   :
pombe   383 MDEDISATSIP-KSQAAYGHGSVTYHEVPRYNLTSASVGYSISSQRGRIKSSSTIDNLSAI---L 443

  Fly   813 QKTPKNSPQMKPVDKPQISFQAI---QPQKSTHSFSPPITTHIVLDQAVQPKSCTQSN------- 867
            .......|.|:||...:.::...   :|.||:.|        :|..::...:....|.
pombe   444 SSEDLRHPSMQPVPGTKRTYSNYCENEPNKSSQS--------LVSSESHNVEGWNYSETGTVGFY 500

  Fly   868 --PAQLSTQMVS-PQSTAPQQPVALGHFLHESLKNGNFFQF--MPLP--------EEPSGTESSC 919
              .|::|..:.. .|||    |||..   .|.|...:.|..  :.||        |.|:|||:..
pombe   501 DPSAEISASIDELRQST----PVARD---SELLSRAHSFDLNRLDLPSQDKSTSYEVPNGTENQS 558

  Fly   920 SASQTT-----ESSVIRQPKLKLPSP----HAHQSLN-NISEQHSP-------PKQNRNLSRSEL 967
            ....|:     |:....:||..||..    |.:..|| :|||.|||       |.||..|....:
pombe   559 PRPVTSLGFVNETFFEEKPKAPLPLGRFYIHLNSILNISISEVHSPIKIIVNTPTQNMQLPWQAV 623

  Fly   968 S----LQRSEIFL--DNLCRSELVLDRPEKVPNNTSNMDSVSYDMPEQLYADYSLVGAGSAGSSF 1026
            :    |.....|.  ||...|.:.||.|.:..:|                        ||.|.|
pombe   624 NGNNRLDHDFAFHVDDNFKVSFMFLDIPIEDKSN------------------------GSKGVS- 663

  Fly  1027 VTNDYGSGQIEPEPANQSTPKKK--------QSQRFTTKPA------SNLTIEINDGQATSLRHF 1077
            .|.|..:|    :||...:..:|        :.:|...|.|      :..::.|.....|:..:.
pombe   664 ATKDVSNG----KPAETKSKARKFFDKLFNRRKKRKLNKAAAVENSKAKKSVVIKKVSGTATLNL 724

  Fly  1078 GN--------------------------------------NLSISCPTTPQQAQASQAVDPTVLH 1104
            ||                                      ||:::|...|:.:...|.:..|
pombe   725 GNVKDSCFGKAFNVEIPIISRGFLEAIPVKINSIGKRTLGNLTLTCLYIPELSVPEQELPFT--- 786

  Fly  1105 NSSSLGELMQTMPNPSDSQLMSVSALARYRLLKNALRRSYRKGKDFFLAEKQRLAQSLNLSRDQS 1169
                |.:....:.:...:.|.:...|  |||..:::||.:     ..|..||     ||...::.
pombe   787 ----LEQATMDLRHVRSNYLYNEGYL--YRLEDSSIRRRF-----VVLRSKQ-----LNFYAEKG 835

  Fly  1170 NQTDGELDSSTYYANFNVDSLLNDSLNPNEQLAQAVSICRQMPTLEISAEMVEAERLLLFSTLRK 1234
            .|   .||  |:..:..|.|:      |....::|||....:  ..|.|..|:...:.||:..:|
pombe   836 GQ---YLD--TFQLSKTVVSI------PMVNFSEAVSNLGLV--AGILATSVDRRHVQLFADSKK 887

  Fly  1235 STPPVCQ-----LNDEALAARRKSQCL 1256
                |||     :|..:.|..|.::.|
pombe   888 ----VCQKWLQVMNSRSFALDRGTEKL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30183	NP_001137745.2	PH_anillin	1438..1549	CDD:269964
CG30183	NP_001137745.2	PH	1442..1546	CDD:278594
mid1	NP_588075.1	PH	805..898	CDD:278594	30/121 (25%)
mid1	NP_588075.1	PH	805..898	CDD:214574	30/121 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21538
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100