Protein Alignment angel and ANGEL2

DIOPT Version :9

• Sequence 1: NP_477204.1
• Gene: angel / 37748
• FlyBaseID: FBgn0016762
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_653168.2
• Gene: ANGEL2 / 90806
• HGNCID: 30534
• Length: 544
• Species: Homo sapiens
• Alignment Length: 388
• Identity: 120/388 - (30%)
• Similarity: 167/388 - (43%)
• Gaps: 84/388 - (21%)

  Fly    10 SLKATSRIIRRSVSSQAKG---ASGKRKQKAK-----EMESSHDRNRRWTSLGNQAEGRDPHKCS 66
            :|..||.|...|....|:|   :|.:||.:..     |...|||:.:. ..||:  :..|| ||.
Human    99 NLSQTSLIHLSSYVMNAEGDEPSSKRRKHQGVIKRNWEYICSHDKEKT-KILGD--KNVDP-KCE 159

  Fly    67 ------SFKVVSYNILAQDLLLEHLFLYVGIPHEFLSWQRRQQNLLRELLKLDPDILCLQEMQFD 125
                  .|.|:|||||:||||.::..||.......|.|..|..|:|:|:...|.|:|||||:|.|
Human   160 DSENKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQED 224

  Fly   126 HL-----PVLVQRLRMGNGKKLAY--VYKKKTGCRTDGCAIVYDSSKFELLDHQAVELYDQAVAL 183
            |.     |.|         :.|.|  .||.:||.:.|||||.:..|||.||....||.:...::|
Human   225 HYGAEIRPSL---------ESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFFRPDISL 280

  Fly   184 LNRDNVALFARFRFKKQQEQQKEFVVATTHLLFNTKRSDVRCAQVERILEELQSFS-----TDTP 243
            |:||||.|....:.|..........||.||||:|.:|.|::..|:..:|.|:.|.:     :..|
Human   281 LDRDNVGLVLLLQPKIPYAACPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGSFCP 345

  Fly   244 IVLTGDFNSLPDSSPIEFL-----------VGK-NGDVDSTACPEPLHFEI-------------- 282
            ||:.|||||:|.|....|:           :|| :|...|:.....|...|
Human   346 IVMCGDFNSVPGSPLYSFIKEGKLNYEGLPIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYE 410

  Fly   283 ---------IDSGEGTASTYQNEWVIVDYILRSLGSRSRHKLLPLSVYS-------LPSINRC 329
                     .||........|.|.::.   ...|.|..:|.....||||       :|.:..|
Human   411 VQQVPKVEKTDSDLTQTQLKQTEVLVT---AEKLSSNLQHHFSLSSVYSHYFPDTGIPEVTTC 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
angel	NP_477204.1	EEP	70..351	CDD:294334	99/314 (32%)
ANGEL2	NP_653168.2	EEP	169..542	CDD:321002	99/314 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143747
Domainoid	1	1.000	135	1.000	Domainoid score	I4986
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4594
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395901at33208
OrthoFinder	1	1.000	-	-		FOG0002618
OrthoInspector	1	1.000	-	-		otm40331
orthoMCL	1	0.900	-	-		OOG6_105310
Panther	1	1.100	-	-	O	PTHR12121
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1517
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.760