DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment angel and Cnot6l

DIOPT Version :9

Sequence 1:	NP_477204.1	Gene:	angel / 37748	FlyBaseID:	FBgn0016762	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	XP_006250770.1	Gene:	Cnot6l / 360917	RGDID:	1309128	Length:	555	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	100/388 - (25%)
Similarity:	152/388 - (39%)	Gaps:	115/388 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 RRWTSLGNQAEGRD---PHKCSSFKVVSYNILAQDLLLEHLFLYVGIPHEFLSWQRRQQNLLREL 109
            |.|.:|    :.||   |  .:||.|:.||:|........|:.|  .|...|:|:.|::.::.|:
  Rat   172 RPWITL----KERDQILP--SASFTVMCYNVLCDKYATRQLYGY--CPSWALNWEYRKKGIMEEI 228

  Fly   110 LKLDPDILCLQEMQFDH-----LPVLVQRLRMG--NGKKLAYVYKKKTGCRTDGCAIVYDSSKFE 167
            :..|.||:.|||::.:.     ||.|..|...|  :.|..|.:..::.....|||||.:.:.||.
  Rat   229 VNWDADIISLQEVETEQYFTLFLPALKDRGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFT 293

  Fly   168 LLDHQAVEL-------YDQAVALLNR----DNVALFARFRFKKQ----------QEQQKEFVVAT 211
            |:....||.       .|.:.|:|||    ||:.:.......|:          ...::..:||.
  Rat   294 LVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGTGMKPIHAADKQLLIVAN 358

  Fly   212 THLLFNTKRSDVRCAQ-------VERILEELQS-------FSTDTPIVLTGDFNSLPDSSPIEFL 262
            .|:.::.:.|||:..|       |:.|||:..|       .....|:||..|.||||||..:|:|
  Rat   359 AHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEYL 423

  Fly   263 --------------------------VGKNGDVDSTACPEPLHFEIIDSGEGTASTYQNEWV--- 298
                                      .||||..:..          |..|....|.|:|..:
  Rat   424 SNGGVADNHKDFKELRYNECLMNFSCSGKNGSSEGR----------ITHGFQLKSAYENNLMPYT 478

  Fly   299 --------IVDYILRS------LGSRSRHKLLPLSVYSLPSINRCIGAGQIPNYRLGSDHYAL 347
                    ::|||..|      ||     .|.||....|.. |...|.   |:..:.|||::|
  Rat   479 NYTFDFKGVIDYIFYSKTHMNVLG-----VLGPLDPQWLVE-NNITGC---PHPHIPSDHFSL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
angel	NP_477204.1	EEP	70..351	CDD:294334	92/363 (25%)
Cnot6l	XP_006250770.1	leucine-rich repeat	38..57	CDD:275378
		LRR	<57..>183	CDD:227223	5/14 (36%)
		leucine-rich repeat	58..80	CDD:275378
		leucine-rich repeat	81..103	CDD:275378
		leucine-rich repeat	104..126	CDD:275378
		leucine-rich repeat	127..138	CDD:275378
		Deadenylase_CCR4b	191..538	CDD:197339	92/363 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337511
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740