DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment angel and cnot6a

DIOPT Version :9

Sequence 1:	NP_477204.1	Gene:	angel / 37748	FlyBaseID:	FBgn0016762	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_997825.1	Gene:	cnot6a / 324048	ZFINID:	ZDB-GENE-030131-2768	Length:	557	Species:	Danio rerio

Alignment Length:	394	Identity:	103/394 - (26%)
Similarity:	159/394 - (40%)	Gaps:	120/394 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 RRWTSLGNQAEGRDPHK---CSSFKVVSYNILAQDLLLEHLFLYVGIPHEFLSWQRRQQNLLREL 109
            |.|..|      ::|.:   .:.|.|:.||:|........|:.|  .|...|:|:.|::::::|:
Zfish   171 RSWIPL------QEPDRTRPAALFSVMCYNVLCDKYATRQLYGY--CPSWALNWEYRKKSIMQEI 227

  Fly   110 LKLDPDILCLQEMQFD-HLPVLVQRLRMGNGKKLAY--VYKKKTGCRT---------DGCAIVYD 162
            |....||:.|||::.: :....:..|     |:..|  .:..|:..||         ||||:.|.
Zfish   228 LSCSADIISLQEVETEQYYNYFLLEL-----KEQGYEGFFSPKSRARTMSESDRKHVDGCAVFYK 287

  Fly   163 SSKFELLDHQAVELYDQAV-------ALLNR----DNVALFARFRFKKQQEQ----------QKE 206
            :.||.|:....||....|:       |:|||    ||:.:......:|:..:          :|:
Zfish   288 TDKFSLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKEMMELSAGKPLHGMEKQ 352

  Fly   207 -FVVATTHLLFNTKRSDVRCAQVERILEE-------------LQSFSTDT---PIVLTGDFNSLP 254
             .:||..|:.::.:.|||:..|....|.|             |.|.|.:|   |:||..|.||||
Zfish   353 LLLVANAHMHWDPEYSDVKLVQTMMFLSEVKNIVDKATRSLKLSSVSGETNAIPLVLCADLNSLP 417

  Fly   255 DSSPIEFLVGKNGDVDSTACPEPLHFEIIDS--------GEGTAST-----------YQNEWV-- 298
            ||..:|:|  ..|.||. |..:......|||        ..||:||           |:|..:
Zfish   418 DSGVVEYL--STGGVDG-AHKDFKELRYIDSLTNFNCNGKNGTSSTRITHGFKLKSAYENGLMPY 479

  Fly   299 ---------IVDYILRS---------LGSRSRHKLLPLSVYSLPSINRCIGAGQIPNYRLGSDHY 345
                     |:|||..|         ||....|.||.         |...|.   |:..:.|||:
Zfish   480 TNYTFDFKGIIDYIFYSQPLLNVLGVLGPLEHHWLLE---------NNVTGC---PHPHIPSDHF 532

  Fly   346 ALGA 349
            :|.|
Zfish   533 SLFA 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
angel	NP_477204.1	EEP	70..351	CDD:294334	98/369 (27%)
cnot6a	NP_997825.1	LRR_8	51..132	CDD:290566
		LRR_4	51..91	CDD:289563
		leucine-rich repeat	53..75	CDD:275378
		leucine-rich repeat	76..90	CDD:275378
		EEP	190..540	CDD:294334	98/369 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576692
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740