DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment angel and NOCT

DIOPT Version :9

Sequence 1:	NP_477204.1	Gene:	angel / 37748	FlyBaseID:	FBgn0016762	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_036250.2	Gene:	NOCT / 25819	HGNCID:	14254	Length:	431	Species:	Homo sapiens

Alignment Length:	395	Identity:	99/395 - (25%)
Similarity:	158/395 - (40%)	Gaps:	86/395 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SRIIRRSVSSQAKGASGKRKQKAKEMESS---------------------------------HDR 46
            :|...|:|.|...|.|......||.:.||                                 |.|
Human    57 ARSCSRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHLEPIDPKELLEECRAVLHTR 121

  Fly    47 ----NRRWTSLGNQAEGRDPHKCSSFKVVSYNILAQDLLLEHLFLYVGIPHEFLSWQRRQQNLLR 107
                .|.:..|........|    ..:|:.:||||| .|.|....:|..|.|.|.|:.|:..:|.
Human   122 PPRFQRDFVDLRTDCPSTHP----PIRVMQWNILAQ-ALGEGKDNFVQCPVEALKWEERKCLILE 181

  Fly   108 ELLKLDPDILCLQEMQ--FDHLPVLVQRLRMGNGKKLAYVYKKKTGC-------RTDGCAIVYDS 163
            |:|...||||||||:.  ||....|:.||    |.:..:..|..:.|       ..||||:.:..
Human   182 EILAYQPDILCLQEVDHYFDTFQPLLSRL----GYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQ 242

  Fly   164 SKFELLDHQAVELYDQAVALLNRDNVALFARFRFKKQQEQQKEFVVATTHLLFNTKRSDVRCAQV 228
            ::|:|::...:.|   ....|..:.||:......|   |..::|.:|.|||...|.....|.||.
Human   243 NRFKLVNSANIRL---TAMTLKTNQVAIAQTLECK---ESGRQFCIAVTHLKARTGWERFRSAQG 301

  Fly   229 ERILEELQSFS--TDTPIVLTGDFNSLPDSSPIEFLVGKNGDVDSTACPEPLHFEIIDSGEGTAS 291
            ..:|:.||:.:  ...|:::.||||:.|.....:.....:.:::|.       :::: |.:|.:.
Human   302 CDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSA-------YKLL-SADGQSE 358

  Fly   292 TYQNEWVI---------VDYILRSLGSRSRHKLLPLSVYSLPSINRCIGAGQIPNYRLGSDHYAL 347
            .....|.|         :|||.     .|:|.|...|...|.:..: ||..::|::...|||.:|
Human   359 PPYTTWKIRTSGECRHTLDYIW-----YSKHALNVRSALDLLTEEQ-IGPNRLPSFNYPSDHLSL 417

  Fly   348 GAVFT 352
            ...|:
Human   418 VCDFS 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
angel	NP_477204.1	EEP	70..351	CDD:294334	83/300 (28%)
NOCT	NP_036250.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..41
		Deadenylase_nocturnin	144..423	CDD:197330	84/304 (28%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:31147539	219..221		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:31147539	286..289		2/2 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:31147539	324..326		1/1 (100%)
		Interaction with PPARG. /evidence=ECO:0000250\|UniProtKB:O35710	343..353		1/17 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810