DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment angel and PDE12

DIOPT Version :9

Sequence 1:	NP_477204.1	Gene:	angel / 37748	FlyBaseID:	FBgn0016762	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_808881.3	Gene:	PDE12 / 201626	HGNCID:	25386	Length:	609	Species:	Homo sapiens

Alignment Length:	384	Identity:	89/384 - (23%)
Similarity:	141/384 - (36%)	Gaps:	103/384 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GKRKQKAKEMES-----------SHDRNRRWTSLGNQAEGRDPHKCSSFKVVSYNILAQDLLLEH 84
            |:|...::|:||           :.|....:|        :...:.:..:.||||||| |...:.
Human   255 GQRFGHSRELESVCVVEAGPGTCTFDHRHLYT--------KKVTEDALIRTVSYNILA-DTYAQT 310

  Fly    85 LF----LYVGIPHEFLSWQRRQQNLLRELLKLDPDILCLQEMQ----FDHL-PVLVQRLRMGNGK 140
            .|    ||.......|....||..:.:||...:.|::||||:.    .|.| |.|       ...
Human   311 EFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADVICLQEVDRAVFSDSLVPAL-------EAF 368

  Fly   141 KLAYVYKKKTGCRTDGCAIVYDSSKFELLDHQAVELYDQAVA--------------------LLN 185
            .|..|::.|   :.:|.|..|..|||.||....:..|:...:                    :|.
Human   369 GLEGVFRIK---QHEGLATFYRKSKFSLLSQHDISFYEALESDPLHKELLEKLVLYPSAQEKVLQ 430

  Fly   186 RDNVALFARFRFKKQQEQQKEFVVATTHLLFNTKRSDVRCAQVERILEELQSFSTD----TPIVL 246
            |.:|...:..:..|  :..|...||.|||.::.|...:|..|:...|..::..|.|    .|::.
Human   431 RSSVLQVSVLQSTK--DSSKRICVANTHLYWHPKGGYIRLIQMAVALAHIRHVSCDLYPGIPVIF 493

  Fly   247 TGDFNSLPDSSPIEFLV-----------GKNGDVD------------STACPEPLHFEIIDSGEG 288
            .|||||.|.:....|::           ..||:.:            .:||.||.:...:....|
Human   494 CGDFNSTPSTGMYHFVINGSIPEDHEDWASNGEEERCNMSLTHFFKLKSACGEPAYTNYVGGFHG 558

  Fly   289 TASTYQNEWVIVDYILRSLGSRSRHKLLPLSVYSLPSINRCIGAGQIPNYRLGSDHYAL 347
                      .:|||...|.:....:::|     |||.........:|:....|||.||
Human   559 ----------CLDYIFIDLNALEVEQVIP-----LPSHEEVTTHQALPSVSHPSDHIAL 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
angel	NP_477204.1	EEP	70..351	CDD:294334	82/334 (25%)
PDE12	NP_808881.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..230
		EEP	299..608	CDD:294334	81/332 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810