DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment angel and Cnot6

DIOPT Version :9

Sequence 1:	NP_477204.1	Gene:	angel / 37748	FlyBaseID:	FBgn0016762	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001277670.1	Gene:	Cnot6 / 104625	MGIID:	2144529	Length:	557	Species:	Mus musculus

Alignment Length:	454	Identity:	108/454 - (23%)
Similarity:	172/454 - (37%)	Gaps:	149/454 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LHNVSLKA---TSRII---------RRSVSSQAKGASGKRKQKAKEMESSHDRNRRWTSLGNQAE 58
            |..:|||.   |..|:         ||.::......||    .||.:.:.....|.|..|
Mouse   122 LQTLSLKGNPLTQDILNLCLEPDGTRRLLNYLLDNLSG----TAKRISTEQPPPRSWIML----- 177

  Fly    59 GRDPHK---CSSFKVVSYNILAQDLLLEHLFLYVGIPHEFLSWQRRQQNLLRELLKLDPDILCLQ 120
             ::|.:   .:.|.|:.||:|........|:.|  .|...|:|..|::.:::|:|..:.||:.||
Mouse   178 -QEPDRTRPTALFSVMCYNVLCDKYATRQLYGY--CPSWALNWDYRKKAIIQEILSCNADIISLQ 239

  Fly   121 EMQFD--HLPVLVQRLRMG-NGKKLAYVYKKKTGCRT---------DGCAIVYDSSKFELLDHQA 173
            |::.:  :...||:....| ||     .:..|:..||         |||||.:.:.||.|:....
Mouse   240 EVETEQYYSFFLVELKERGYNG-----FFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHT 299

  Fly   174 VELYDQAV-------ALLNR----DNVALFARFRFKKQQEQ----------QKEFV-VATTHLLF 216
            ||....|:       |:|||    ||:.:......:|:..:          :|:.: ||..|:.:
Mouse   300 VEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKELIEMSSGKPHLGTEKQLILVANAHMHW 364

  Fly   217 NTKRSDVRCAQVERILEELQSFSTDT---------------PIVLTGDFNSLPDSSPIEFLV--- 263
            :.:.|||:..|....|.|:::.....               |:||..|.||||||..:|:|.
Mouse   365 DPEYSDVKLVQTMMFLSEVKNIIDKASRSLKSSVLGECGTIPLVLCADLNSLPDSGVVEYLSTGG 429

  Fly   264 -----------------------GKNGDVDSTACPEPLHFEIIDSGEGTASTYQNEWV------- 298
                                   ||||..:..          |..|....|.|:|..:
Mouse   430 VETNHKDFKELRYNESLTNFSCNGKNGMTNGR----------ITHGFKLKSAYENGLMPYTNYTF 484

  Fly   299 ----IVDYILRS---------LGSRSRHKLLPLSVYSLPSINRCIGAGQIPNYRLGSDHYALGA 349
                |:|||..|         ||....|.|:.      .:|:.|      |:..:.|||::|.|
Mouse   485 DFKGIIDYIFYSKPQLNTLAILGPLDHHWLVE------NNISGC------PHPLIPSDHFSLFA 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
angel	NP_477204.1	EEP	70..351	CDD:294334	91/375 (24%)
Cnot6	NP_001277670.1	LRR	<52..>159	CDD:227223	8/36 (22%)
		LRR 1	52..73
		leucine-rich repeat	53..75	CDD:275378
		LRR 2	75..96
		leucine-rich repeat	76..98	CDD:275378
		LRR 3	98..120
		leucine-rich repeat	99..121	CDD:275378
		LRR 4	121..143		6/20 (30%)
		leucine-rich repeat	122..133	CDD:275378	4/10 (40%)
		Nuclease domain. /evidence=ECO:0000250	153..557		100/423 (24%)
		Deadenylase_CCR4a	191..540	CDD:197340	91/375 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833977
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740