Protein Alignment l(2)efl and CRYAB

DIOPT Version :9

• Sequence 1: NP_001261156.1
• Gene: l(2)efl / 37744
• FlyBaseID: FBgn0011296
• Length: 187
• Species: Drosophila melanogaster
• Sequence 2: NP_001276736.1
• Gene: CRYAB / 1410
• HGNCID: 2389
• Length: 175
• Species: Homo sapiens
• Alignment Length: 162
• Identity: 71/162 - (43%)
• Similarity: 97/162 - (59%)
• Gaps: 22/162 - (13%)

  Fly    17 FPMRT-SRLLDQHFGQGLKRDDLMSSVWNSRPTVLRSGYLRP--------WHTNSLQKQESGSTL 72
            ||..: |||.||.||:.|...||..:     .|.|...||||        |....|      |.:
Human    15 FPFHSPSRLFDQFFGEHLLESDLFPT-----STSLSPFYLRPPSFLRAPSWFDTGL------SEM 68

  Fly    73 NIDSEKFEVILDVQQFSPSEITVKVADKFVIVEGKHEEKQDEHGYVSRQFSRRYQLPSDVNPDTV 137
            .::.::|.|.|||:.|||.|:.|||....:.|.|||||:|||||::||:|.|:|::|:||:|.|:
Human    69 RLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTI 133

  Fly   138 TSSLSSDGLLTIKAPMKALPPPQTERLVQITQ 169
            ||||||||:||:..|.|.:..|  ||.:.||:
Human   134 TSSLSSDGVLTVNGPRKQVSGP--ERTIPITR 163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)efl	NP_001261156.1	metazoan_ACD	71..153	CDD:107247	43/81 (53%)
CRYAB	NP_001276736.1	Crystallin	1..52	CDD:395419	17/41 (41%)
		ACD_alphaB-crystallin_HspB5	67..150	CDD:107246	44/82 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..175		7/20 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148908
Domainoid	1	1.000	105	1.000	Domainoid score	I6645
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68209
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4724
Isobase	1	0.950	-	0	Normalized mean entropy	S4216
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	1	1.000	-	-		otm41738
orthoMCL	1	0.900	-	-		OOG6_101545
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6558
SonicParanoid	1	1.000	-	-		X393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.880