DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)efl and Cryaa

DIOPT Version :9

Sequence 1:	NP_001261156.1	Gene:	l(2)efl / 37744	FlyBaseID:	FBgn0011296	Length:	187	Species:	Drosophila melanogaster
Sequence 2:	NP_001265498.1	Gene:	Cryaa / 12954	MGIID:	88515	Length:	202	Species:	Mus musculus

Alignment Length:	203	Identity:	71/203 - (34%)
Similarity:	102/203 - (50%)	Gaps:	37/203 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WWDELDFPMRTSRLLDQHFGQGLKRDDLM------------SSVWNSRPTVLRSG----YLRPWH 59
            |:.....|...|||.||.||:||...||:            .|::.   |||.||    ....|.
Mouse     9 WFKRALGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFR---TVLDSGISELMTHMWF 70

  Fly    60 T----------NSLQKQESGSTLNIDSEKFEVILDVQQFSPSEITVKVADKFVIVEGKHEEKQDE 114
            .          |:..|....:.:..|.:||.:.|||:.|||.::||||.:.||.:.|||.|:||:
Mouse    71 VMHQPHAGNPKNNPVKASYMAKVRSDRDKFVIFLDVKHFSPEDLTVKVLEDFVEIHGKHNERQDD 135

  Fly   115 HGYVSRQFSRRYQLPSDVNPDTVTSSLSSDGLLTIKAP--MKALPPPQTERLVQITQTGPSSKED 177
            |||:||:|.|||:|||:|:...::.|||:||:||...|  ...|....:||.:      |.|:|:
Mouse   136 HGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKVQSGLDAGHSERAI------PVSREE 194

  Fly   178 NAKKVETS 185
            ......:|
Mouse   195 KPSSAPSS 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)efl	NP_001261156.1	metazoan_ACD	71..153	CDD:107247	42/83 (51%)
Cryaa	NP_001265498.1	Crystallin	1..50	CDD:278926	13/40 (33%)
		alpha-crystallin-Hsps_p23-like	90..174	CDD:294116	41/83 (49%)
		IbpA	<93..174	CDD:223149	41/80 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838985
Domainoid	1	1.000	105	1.000	Domainoid score	I6647
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	126	1.000	Inparanoid score	I4671
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	1	1.000	-	-		otm43786
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6558
SonicParanoid	1	1.000	-	-		X393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930