Protein Alignment Pde8 and PDE8B

DIOPT Version :10

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_001336678.1
• Gene: PDE8B / 8622
• HGNCID: 8794
• Length: 906
• Species: Homo sapiens
• Alignment Length: 1006
• Identity: 350/1006 - (34%)
• Similarity: 498/1006 - (49%)
• Gaps: 186/1006 - (18%)

  Fly    91 STAVPANGGI--RPKSEGACPEMKVETISAATSPPPPRPLHGTSGPVAISLPFVGRNSSKTPEEM 153
            |..|..:|.|  |...|.:.|.   :|.|.:..|..|.|
Human     6 SIHVSQSGVIYCRDSDESSSPR---QTTSVSQGPAAPLP-------------------------- 41

  Fly   154 ELEYEANVEAESRDIMTPLRRNTRPLSVS--------FGGGGGRSALQPEIVEAIRSLDVPALRL 210
                ...|:.::.|.:.|.|.:..| ||:        .|.|....:..|
Human    42 ----GLFVQTDAADAIPPSRASGPP-SVARVRRARTELGSGSSAGSAAP---------------- 85

  Fly   211 NNLSFDGSTDPKGERNH----AEEEPLT------PGHDHEDSVVLRRKVNCLERKAHSLYERRLP 265
                  .:|..:|.|.|    ||.|..|      .|.....|.:..:||:..
Human    86 ------AATTSRGRRRHCCSSAEAETQTCYTSVKIGASQTSSNLRVKKVDAY------------- 131

  Fly   266 RVPKLHLLVAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQ 330
                ||..|:        ..|.|.....|          ...|::.||:|.|.||..:....||.
Human   132 ----LHQQVS--------SAEVRIGPMRL----------TQDPIQVLLIFAKEDSQSDGFWWACD 174

  Fly   331 RHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAV 395
            |......:.::.|.||:.....:     :.:|:||.|.::|.|||.:.|:||.|:....|.|:||
Human   175 RAGYRCNIARTPESALECFLDKH-----HEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAV 234

  Fly   396 CKKSFFEKDDV-LIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRL 459
            ..:...:.::. ::.||.||.||...|.:::..|..||.||.|..:|....:....:::|||...
Human   235 VSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHC 299

  Fly   460 KEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSD------LSTISEQCKNIKEFDG 518
            .|.:.||.|...|||.|.|.||::.....|::.|:|.|:..||      |.||:...|..||:.|
Human   300 HEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQG 364

  Fly   519 ILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSV--- 580
            :...||||.:.|..||::.||...|....|.:       .......|....|:     :|.:
Human   365 VYYARRKSGDSIQQHVKITPVIGQGGKIRHFV-------SLKKLCCTTDNNKQ-----IHKIHRD 417

  Fly   581 -----------------RRCSFDVRSIASDG--------LRRTSLAKLTSLPLEAPITKIINLLS 620
                             |:.|.||:||:|.|        .|..|:|::.|:.:||||||:||:::
Human   418 SGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIIN 482

  Fly   621 QVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSI 685
            ..|||.....|..:|:|||.|:...|||||: ..:.:||..:||:|.|:|.    ..||.|.:..
Human   483 AAQENSPVTVAEALDRVLEILRTTELYSPQL-GTKDEDPHTSDLVGGLMTD----GLRRLSGNEY 542

  Fly   686 IRTGSSTRTAAIVPAKMKSN---PIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDV 747
            :.|.:..::.:.:...:..|   |.|.:|||...||||:||:||.||...||:|||:::|.||.|
Human   543 VFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGV 607

  Fly   748 FATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATAL 812
            ...||..|...:||..||||:|..||.||||||||||:.||..|:.:...|..|  |:::|..||
Human   608 CEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSL--DQLDEVAAL 670

  Fly   813 IAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYK 877
            |||..||||||||:::||||:...|||||||..|||:||.|:.|:||:.|.|.|||||:|:..|:
Human   671 IAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYR 735

  Fly   878 SARSTIIDMILATEMTRHFEHLAKFVS---------VFGGEEPRDHNP--QTDEETSILMRRMLI 931
            :.|..||||:||||||:||||:.|||:         :.|.:  .:.||  :...|..||::||:|
Human   736 TLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSD--CECNPAGKNFPENQILIKRMMI 798

  Fly   932 KVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQ 996
            |.|||:||.||:..|||||.||:||||.||||||::.||:|||:|||.|||||||||.||:|.|.
Human   799 KCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 863

  Fly   997 DMMHAWESFIDMPQLITYMQINYSQWKKYDE 1027
            ||..||::|..:|.|:.::..||..||..|:
Human   864 DMFDAWDAFAHLPALMQHLADNYKHWKTLDD 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	NtrB	446..>539	CDD:443061	34/98 (35%)
		PDEase_I	775..1016	CDD:459723	139/251 (55%)
PDE8B	NP_001336678.1	PDE8	1..47	CDD:400795	13/73 (18%)
		PleD	175..>256	CDD:442920	24/85 (28%)
		PAS	294..>397	CDD:441804	38/109 (35%)
		PDEase_I	635..882	CDD:459723	139/250 (56%)