DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde8 and PDE2

DIOPT Version :9

Sequence 1:NP_001163275.2 Gene:Pde8 / 37741 FlyBaseID:FBgn0266377 Length:1050 Species:Drosophila melanogaster
Sequence 2:NP_015005.1 Gene:PDE2 / 854542 SGDID:S000005887 Length:526 Species:Saccharomyces cerevisiae


Alignment Length:482 Identity:111/482 - (23%)
Similarity:173/482 - (35%) Gaps:141/482 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   593 DGLRRTSLAKL--TSLPLEAPITKIINLL-----SQVQENCSADEARLIDKV--LEFLKREGLYS 648
            ||:.:.|...:  .|:|.:|....|..||     |:.|....|...|||..:  :.||       
Yeast   133 DGINKNSYGTVNGNSVPTQACEANIYTLLLHLNDSKAQHLRKASVPRLIRNIEFMSFL------- 190

  Fly   649 PQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLD 713
                    .|||                      :.|.:.||.                ...:|.
Yeast   191 --------SDPI----------------------EKISQEGSH----------------YWNILS 209

  Fly   714 ESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNS 778
               :|||....|..    ..|::.|..:.::....|.:.|.:|.....|..:|:.|.:.|.:||.
Yeast   210 ---TWDFCALSLST----QELIWCGFTLIKKLSKDAKVLIADNKLLLLLFTLESSYHQVNKFHNF 267

  Fly   779 THAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYND 843
            .||.||||||....|.|. ||    :.::.....:||..|||.|||.::..|||....:|..:.:
Yeast   268 RHAIDVMQATWRLCTYLL-KD----NPVQTLLLCMAAIGHDVGHPGTNNQLLCNCESEVAQNFKN 327

  Fly   844 LTVLENHHAAITFKLTLGDDKINIFKNLDKETY-------KSARSTIIDMILATEMTRHFEHLAK 901
            :::|||.|.             .:|:.|..|.:       |.....|.:.||||:|..|.::   
Yeast   328 VSILENFHR-------------ELFQQLLSEHWPQLLSISKKKFDFISEAILATDMALHSQY--- 376

  Fly   902 FVSVFGGEEPRDH-NPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEY----FMQT 961
                   |:...| ||.    ..|.:..::||.||:||..|.:.....||..|..|:    .::|
Yeast   377 -------EDRLMHENPM----KQITLISLIIKAADISNVTRTLSISARWAYLITLEFNDCALLET 430

  Fly   962 DEEKQR---------HLPIVMPMFDRATCS------------------IPKSQIGFIEYIIQDMM 999
            ..:..|         :..:..|..|..:..                  ||..||.||....:...
Yeast   431 FHKAHRPEQDCFGDSYKNVDSPKEDLESIQNILVNVTDPDDIIKDHPHIPNGQIFFINTFAEVFF 495

  Fly  1000 HAW-ESFIDMPQLITYMQINYSQWKKY 1025
            :|. :.|..:..|...::||...|.|:
Yeast   496 NALSQKFSGLKFLSDNVKINKEYWMKH 522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde8NP_001163275.2 PAS 459..539 CDD:238075
PAS_9 463..539 CDD:290162
PDEase_I 775..1016 CDD:278654 70/280 (25%)
PDE2NP_015005.1 PDEase_I 264..513 CDD:395177 70/280 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 82 1.000 Domainoid score I1950
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000302
OrthoInspector 1 1.000 - - otm46491
orthoMCL 1 0.900 - - OOG6_105168
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2223
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.840

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