DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde1c

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_112340.1	Gene:	Pde1c / 81742	RGDID:	68332	Length:	768	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	131/507 - (25%)
Similarity:	230/507 - (45%)	Gaps:	89/507 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 RRKSQ--------EGIPMHVRVVPVACI--GSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSL 577
            |.|||        :|:..:|:..|...|  .:.|...|...::|  |:|              |.
  Rat    46 RSKSQNCLWNSLIDGLTGNVKEKPRPTIVQDTRPPEEILADELP--QLD--------------SP 94

  Fly   578 HSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLK 642
            .::.:.||.:||:...              ||.....:::|...::...:..|:..||:....|.
  Rat    95 EALVKTSFRLRSLVKQ--------------LERGEASVVDLKKNLEYAATVLESVYIDETRRLLD 145

  Fly   643 REGLYSPQMKEIRTD--DPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKM--- 702
            .|    .::.:|::|  .....|.:.:..|.......|||......::......|.|...:|
  Rat   146 TE----DELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRR 206

  Fly   703 KSN-------PIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKA 760
            .||       |.:::.|.:..:|.||:|.|.|.:..|.|.::..|:..|:|:.:...|..:...:
  Rat   207 TSNMVGLSYPPAVIDALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS 271

  Fly   761 WLAVIEAHYRK-SNTYHNSTHAADVMQA-------TGA--FITQLTNKDMLVMDRMEEATALI-A 814
            ::..:|..|.| .|.|||..|||||.|.       ||.  ::|:|            |..|:| :
  Rat   272 FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTEL------------EIFAIIFS 324

  Fly   815 AAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSA 879
            ||.||.:|.|.::.|...:....|:||||.:||||||.:..::|...|:::||..||.|:.::..
  Rat   325 AAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREF 389

  Fly   880 RSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQ 944
            |:.:|:|::||:|:.||:.:....:..       ..|:..|:...|  .:::..||:|:||:...
  Rat   390 RTLVIEMVMATDMSCHFQQIKAMKTAL-------QQPEAIEKPKAL--SLMLHTADISHPAKAWD 445

  Fly   945 FCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQ 996
            ....|...:.||:|.|.|.|.:..||. .|:.||.:..:.:||:|||::|::
  Rat   446 LHHRWTMSLLEEFFRQGDREAELGLPF-SPLCDRKSTMVAQSQVGFIDFIVE 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	6/23 (26%)
		PAS_9	463..539	CDD:290162	6/23 (26%)
		PDEase_I	775..1016	CDD:278654	75/232 (32%)
Pde1c	NP_112340.1	PDEase_I_N	146..202	CDD:285672	10/59 (17%)
		PDEase_I	287..515	CDD:278654	75/232 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..557
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347782
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850