DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and Pde1a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_110498.1	Gene:	Pde1a / 81529	RGDID:	68329	Length:	542	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	113/409 - (27%)
Similarity:	195/409 - (47%)	Gaps:	44/409 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   608 LEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDD--PIATDLIGALLT 670
            ||.....:::|...::...|..||..||:....|..|    .::.:|:||.  ....|.:.:..|
  Rat    42 LEKGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTE----DELSDIQTDSVPSEVRDWLASTFT 102

  Fly   671 GPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKM-KSN---------PIIMELLDESLSWDFDIFKL 725
            .....:.::.......|:......|.|...:| :.|         ..::..|.|...|.||:|.|
  Rat   103 RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKNYHMVGLTYPAAVIVTLKEVDKWSFDVFAL 167

  Fly   726 EEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRK-SNTYHNSTHAADVMQA-- 787
            .|.:..|.|.::..|:|...|:.....|..:...|:...:|..|.| .|.|||..|||||.|.
  Rat   168 NEASGEHSLKFMIYELFTSNDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAADVTQTVH 232

  Fly   788 -----TGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVL 847
                 || .:..||..::|.|        :.|||.||.:|.|.::.|...:...:|:||||.:||
  Rat   233 YIMLHTG-IMHWLTELEILAM--------VFAAAVHDYEHTGTTNNFHIQTRSDVAILYNDRSVL 288

  Fly   848 ENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPR 912
            ||||.:..::| :.::::||..||.|:.::..|:.:|:.:|||:|:.||:.:....|..
  Rat   289 ENHHVSAAYRL-MQEEEMNILVNLSKDDWRDLRNLVIETVLATDMSGHFQQIKNIRSSL------ 346

  Fly   913 DHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFD 977
             ..|:..:....:  .:::..||:|:||:..:....|...:.||:|:|.|:|.:..||. .|:.|
  Rat   347 -QQPEGIDRAKTM--SLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPF-SPLCD 407

  Fly   978 RATCSIPKSQIGFIEYIIQ 996
            |.:..:.:||||||::|::
  Rat   408 RKSTMVAQSQIGFIDFIVE 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	74/229 (32%)
Pde1a	NP_110498.1	PDEase_I_N	77..133	CDD:285672	9/59 (15%)
Pde1a	NP_110498.1	PDEase_I	218..434	CDD:278654	74/229 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920