DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and pde9aa

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_009302928.1	Gene:	pde9aa / 799942	ZFINID:	ZDB-GENE-130920-1	Length:	509	Species:	Danio rerio

Alignment Length:	533	Identity:	148/533 - (27%)
Similarity:	239/533 - (44%)	Gaps:	113/533 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   581 RRCS-FDVRSI--ASDGL-RRTSLAKLTS----------LP--LEAPITKII------------- 616
            |.|| .|::.:  .:.|| |.||::.|.|          :|  .|....|::
Zfish    26 RFCSPCDIKELFCTATGLSRNTSISLLDSTGAMVSIDPTMPNNTERSPYKVVPVTGSQLADKEEL 90

  Fly   617 --NLLSQVQENCS------------ADEARLIDKVLEFLKREGLYSPQMKEIRTD-DPIATDLIG 666
              |:|:||.|..|            .:...:::|.:|.   ||:...::::.|:| ..:..::
Zfish    91 FQNVLTQVAEQFSRAFKINELKTEVTNRLAMLEKRVEL---EGMKVVEIEKCRSDIKKLREEM-- 150

  Fly   667 ALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPA--KMKSNPIIMELLDESLSWDFDIFKLEEIT 729
                     :||  :|.|.:...........||:  |...:...:|.|.:.|   ||:::.|.
Zfish   151 ---------ASR--NNSSFLEDNKKLTPRRDVPSYPKYHLSQDTVEALKQPL---FDVWQWES-- 199

  Fly   730 DYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFI-- 792
              :.:|.....|:....:....||:....|.||..|..:|| :|.:||..|...|.|...:.|
Zfish   200 --NEMLSCLEHMYHDLGLVKDFNINPITLKRWLLCIHDNYR-NNPFHNFRHCFCVTQMMYSMIYL 261

  Fly   793 ----TQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAA 853
                .:.|..|:|::        :.||..||:||||.::.:..|:...|||.|||::.|||||.|
Zfish   262 CGLQEKFTQVDILIL--------MTAAVCHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCA 318

  Fly   854 ITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKF---VSVFGGEEPRDHN 915
            :.|::....| .|||.:.|.|.:|..|...|.:||||:|.||.|.:..|   |..|      |:|
Zfish   319 VAFQIFSQPD-CNIFASFDPEAFKQIRQGTITLILATDMARHGEIMDSFKQKVDSF------DYN 376

  Fly   916 PQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRAT 980
               :||....::.:|||..|:||..|||:....|...:.||||||:|.||...|| |.|..||..
Zfish   377 ---NEEHVTCLKMVLIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKAEGLP-VAPFMDREK 437

  Fly   981 CSIPKSQIGFIEYIIQDMMHAWESFIDM-PQLITYM-------QINYSQWKKYDEQGVNTLAEIM 1037
            .:.|.:|||||::::..|   :|:.:.: ||:...|       :..|.:.|:.|:    .:.|:.
Zfish   438 VTKPTAQIGFIKFVLIPM---FETVMKLFPQIEEVMVQPLRESRDKYEELKQIDD----AMNEMQ 495

  Fly  1038 AKQPPVGKMANSK 1050
            .|:.....|...|
Zfish   496 KKKTENVTMGGKK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	91/257 (35%)
pde9aa	XP_009302928.1	PDEase_I	242..472	CDD:278654	91/251 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950