DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and pde8a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001074096.1	Gene:	pde8a / 791145	ZFINID:	ZDB-GENE-070112-622	Length:	817	Species:	Danio rerio

Alignment Length:	869	Identity:	328/869 - (37%)
Similarity:	464/869 - (53%)	Gaps:	130/869 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 AEEEPLTPGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGKKNPPTEEEEFRTFQR 292
            :||.|.|..|.|          .|                           .|.|.:......|.
Zfish    21 SEEPPHTHSHTH----------TC---------------------------TPDTGDRSSAGGQG 48

  Fly   293 NLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLDVTLVKSKEEALD-TLQKSYATA 356
            :|.:|::..:......|:.||||.:.|:...:..:||:|.....::.::.|.||: .||||
Zfish    49 SLTELQFGPMKLNEDQLQVLLVFARDDAQSSSFISACERCGFGCSVCRTPEAALECVLQKS---- 109

  Fly   357 QCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCVAE 421
              ..|||||.|..:.||.|.:.|:||.....|.|.|:||.|:...|:..|: .|:.||.||...|
Zfish   110 --PDLIIIDHRHPRGLDGEALCRSIRAVSCSHNTVIVAVVKRPDREEATVM-PLISAGFNRRFVE 171

  Fly   422 TTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMR 486
            .:::..|..||.|:.|..||....:....||:|||.:.:|.:.|:.:...|||.|.|.|.::..:
Zfish   172 NSSMMSCYNELLQLHHGEIRAQIKLRACNALFTALEQSQEAIEISSEDHIIQYVNPAYECMMGYQ 236

  Fly   487 LDEIISKQLE---------DIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACI 542
            ..|::.:..|         |:    |..||......||:.|:...::|:.:.:..:||:.||  |
Zfish   237 CGELLKENTEVPKSERNRPDL----LDNISSCMLRGKEWQGVYYAKKKNGDSVQQNVRMTPV--I 295

  Fly   543 GSAPTHLIFNFDVPGGQMDFIATLPQP-------------------KEAPRGSLHSVRR-CSFDV 587
            |.            ||::....::.:|                   .:.|:.|.|..|| .|.||
Zfish   296 GQ------------GGKVRHCVSVNRPLNDHNKTEKSCERVQAESQTDIPQSSKHKDRRKGSLDV 348

  Fly   588 RSIASDG------LRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGL 646
            ||..|.|      .|.:|:|::.|:.:||||||:||:::..||:.....|..:|:|||.|:...|
Zfish   349 RSTTSRGSDGSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPLPVAEALDRVLEILRSSEL 413

  Fly   647 YSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTG-----SSTRTAAIVPAKMKSNP 706
            ||||: ..:.:||...||:|.|:|..   ..|.|.|:.|..|.     :|.:|   .|..:...|
Zfish   414 YSPQL-ATKEEDPHTNDLVGGLMTDG---LRRLSGNEYIFTTKQLHHMTSHQT---TPLSLNDIP 471

  Fly   707 -IIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYR 770
             .|.:.::...|||||||.||..|...||.:||:::|.||.|...|...|...::||..|||.|.
Zfish   472 QCIAQTMENEDSWDFDIFNLESATLKRPLAFLGLKLFSRFGVCEFLGCAEATLRSWLQNIEASYH 536

  Fly   771 KSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSND 835
            .||.||||||||||:.||..|:.:...|..|  |.::|..||||||.||||||||:::||||:..
Zfish   537 GSNPYHNSTHAADVLHATAYFLCKERVKQSL--DPIDEVAALIAAAVHDVDHPGRTNSFLCNAGS 599

  Fly   836 ALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLA 900
            .|||||||..|||:||||:.|::|..|||.|||:|:::..|::.|..||||:||||||:||||:.
Zfish   600 ELAVLYNDTAVLESHHAALAFQITTRDDKSNIFRNMERNEYRTLRQAIIDMVLATEMTKHFEHVN 664

  Fly   901 KFVSVF----------GGEEPRD--HNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRI 953
            |||:..          ||.:..|  .:..|..|..||::|||||.||:|||.||::.|||||.||
Zfish   665 KFVNSINKPLAALEENGGSDDEDSVKSVLTSPENRILVKRMLIKCADISNPCRPLELCIEWAGRI 729

  Fly   954 AEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQIN 1018
            :||||.||||||||.||:|||:|||.|||||||||.||:|.|.||..||::|.|:|.|:.::..|
Zfish   730 SEEYFAQTDEEKQRGLPVVMPVFDRHTCSIPKSQISFIDYFITDMFDAWDAFADLPNLMQHLDNN 794

  Fly  1019 YSQWKKYDEQGVNTLAEIMAKQPP 1042
            :..||..|||.:.:|     :.||
Zfish   795 FKYWKSLDEQKLRSL-----RAPP 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	20/88 (23%)
		PAS_9	463..539	CDD:290162	19/84 (23%)
		PDEase_I	775..1016	CDD:278654	144/252 (57%)
pde8a	NP_001074096.1	OmpR	67..>158	CDD:223816	34/96 (35%)
		REC	68..>155	CDD:238088	34/92 (37%)
		PAS_9	211..307	CDD:290162	26/113 (23%)
		PAS	215..311	CDD:238075	25/113 (22%)
		PDEase_I	541..792	CDD:278654	144/252 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	496	1.000	Inparanoid score	I1349
OMA	1	1.010	-	-		QHG50014
OrthoDB	1	1.010	-	-		D80286at33208
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm24749
orthoMCL	1	0.900	-	-		OOG6_105168
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910