DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and pde4b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_031756141.1	Gene:	pde4b / 780324	XenbaseID:	XB-GENE-963512	Length:	733	Species:	Xenopus tropicalis

Alignment Length:	441	Identity:	140/441 - (31%)
Similarity:	222/441 - (50%)	Gaps:	64/441 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 VRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREG---LYS 648
            |..:||:..:|....:||.|      :::....:||.|..|:          .||.::.   :.|
Frog   240 VSEMASNKFKRMLNRELTHL------SEMSRSGNQVSEYISS----------TFLDKQNDVEIPS 288

  Fly   649 PQMK--EIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMEL 711
            |..|  |.:....:.|.:.|.    ..:..|...:|.|:.|.|          .|.:...::.:.
Frog   289 PTQKDREKKKKQQLMTQISGV----KKLMHSSSLNNTSMSRFG----------VKTEYEDMLSKE 339

  Fly   712 LDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYH 776
            |::...|..:|||:...:...||..:...:|:..|:..|..|..:....:...:|.||.....||
Frog   340 LEDLNKWGLNIFKVASYSCNRPLTCIMYAIFQERDLLKTFKIPADTLITYTMTLEDHYHSDVAYH 404

  Fly   777 NSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLY 841
            ||.|||||.|:|...::  |.....|...:|...|:.|||.|||||||.|:.||.|:|..||::|
Frog   405 NSLHAADVTQSTHVLLS--TPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMY 467

  Fly   842 NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVF 906
            ||.:||||||.|:.||| |.::..:||:||.|:..:|.|..:|||:|||:|::|...||...::.
Frog   468 NDESVLENHHLAVGFKL-LQEEHCDIFQNLTKKQRQSLRKMVIDMVLATDMSKHMSLLADLKTMV 531

  Fly   907 GGEEPRDHNPQTDEETS------------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFM 959
                      :|.:.||            |.:.|.::..||:|||.:.::...:|..||.||:|.
Frog   532 ----------ETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQ 586

  Fly   960 QTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQ 1010
            |.|:|::|.:.| .||.|:.|.|:.|||:|||:||:..:   ||::.|:.|
Frog   587 QGDKERERGMEI-SPMCDKHTASVEKSQVGFIDYIVHPL---WETWADLVQ 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	101/248 (41%)
pde4b	XP_031756141.1	PDE4_UCR	164..279	CDD:407935	12/54 (22%)
pde4b	XP_031756141.1	PDEase_I	403..644	CDD:395177	101/248 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920