Protein Alignment Pde8 and pde5a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_012821480.2
• Gene: pde5a / 780273
• XenbaseID: XB-GENE-479676
• Length: 943
• Species: Xenopus tropicalis
• Alignment Length: 806
• Identity: 176/806 - (21%)
• Similarity: 304/806 - (37%)
• Gaps: 158/806 - (19%)

  Fly   338 LVKSKEEALDTLQK---SYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKS 399
            |..|:::.|..||.   |.|..||..|:.:....|.:||    ..|:.|....|:..:||..:.|
 Frog   191 LSDSEKKELMPLQPPSLSRAGDQCSRLLELVKDISSHLD----VTTLCHKIFLHIHELIAADRYS 251

  Fly   400 FF-------EKDDVLIALLDAGVNRCVAETTNLAMCSVELKQILHSII---RPHNVMST-QQALY 453
            .|       .|..::..|.|......|.:.:|..:.....|.|:..:.   :|.|:... |.:.:
 Frog   252 LFLVCEDSSNKKFLVSRLFDVAEGTTVEQASNNCIRLEWNKGIVGHVAEFGQPLNIKDAYQDSRF 316

  Fly   454 TALHRLKEVVLI----TDDLLRIQYANRATE-----RLLNMR--LDEIISKQLEDIFVSDLSTIS 507
            .|     ||..|    |..:|.:...|...|     :.:|.:  .:...:.|.|..|.:.|:...
 Frog   317 NA-----EVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGSNGTFTDQDEKDFAAYLAFCG 376

  Fly   508 EQCKNIKEFDGILTVRRKSQ-----------EGIPMHVRVVPVACI------GSAPTHLIFNFDV 555
            ....|.:.::..|...|::|           |...:.|.:..:|..      ....|..|.:.|.
 Frog   377 IVLHNAQLYETSLLENRRNQVLLDLATLIFEEQQSLEVILKKIAATILSFMQAQRCTIFIVDEDS 441

  Fly   556 PGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSI----------ASDGLRRTSLAKLTSLP--- 607
            |.   .|.:......:....|..:|:| .:||..:          ..:.:....:.|.|..|
 Frog   442 PD---TFSSVFHMESDELEESADAVKR-EYDVSKMNYMYAQYVANTMEAINIPDICKDTRFPWTN 502

  Fly   608 -------------LEAPI-----TKII---NLLSQVQENCSADEARLIDKVLEFLKRE------- 644
                         |.:||     .|:|   .|:::|.||..        |:..|.|.:
 Frog   503 GNEEKNFKHIQSLLCSPIKNAKKNKVIGVCQLVNKVDENSG--------KIKAFNKNDEQFLEAF 559

  Fly   645 ------GLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMK 703
                  |:.:.||.|: .:..:|..::...:......::...:.:..:..|      ||||:...
 Frog   560 AIFCGLGIQNTQMFEV-VERAMAKQMVTLEILSYHASAAEEETMELQVTAG------AIVPSAQS 617

  Fly   704 SNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNID-ENVCKAWLAVIEA 767
            ..      |.|....||      |::|....|... .||...::..|..:. |.:|: |:..::.
 Frog   618 LK------LTEFYFSDF------ELSDMETTLATS-RMFTDLNLVQTFQMKYETLCR-WILSVKK 668

  Fly   768 HYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCN 832
            :|||:..|||..||.:..|.  .|....|.|....::.:|....:||..:||:||.|.:::|:..
 Frog   669 NYRKNVAYHNWRHAFNTAQC--MFAALRTGKIQGKLNDLEILALMIATLSHDLDHRGVNNSFIQR 731

  Fly   833 SNDALAVLYNDLTVLENHHAAITFK---LTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTR 894
            |...||.||.. :::||||    |.   :.|......|...|..:.||:....|...||||::..
 Frog   732 SEHPLAQLYCH-SIMENHH----FDQCLMILNSQGNQILSGLSVQDYKTVLKMIKQAILATDLAL 791

  Fly   895 HFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFM 959
            :.:..:.|..:...::.:..:|...|    |...||:...|:|...:|.......|..:|.|::.
 Frog   792 YIKRRSDFFELVNKKKFKWDDPSQKE----LFLAMLMTACDLSAITKPWPVQQRIAELVASEFYD 852

  Fly   960 QTDEEKQRHL---PIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQ----LITYMQI 1017
            |.|:|: |.|   ||.: |.......||..|:|||:.:..::   :|:...:.:    |:...|.
 Frog   853 QGDKER-RELNIEPIDL-MNREKKDKIPSMQVGFIDAVCLEL---YEALTQISESCYPLLDGCQR 912

  Fly  1018 NYSQWKKYDEQGVNTLAEIMAKQPPV 1043
            |...|:...||....|......||.|
 Frog   913 NRQMWQILAEQQEKNLVNGAKSQPEV 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	18/101 (18%)
		PAS_9	463..539	CDD:290162	16/97 (16%)
		PDEase_I	775..1016	CDD:278654	66/250 (26%)
pde5a	XP_012821480.2	GAF	229..386	CDD:214500	32/165 (19%)
		GAF	412..577	CDD:214500	31/177 (18%)
		PDEase_I	676..911	CDD:395177	66/250 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920