Protein Alignment Pde8 and pde2a

DIOPT Version :10

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_031751996.1
• Gene: pde2a / 780063
• XenbaseID: XB-GENE-5945995
• Length: 964
• Species: Xenopus tropicalis
• Alignment Length: 1039
• Identity: 219/1039 - (21%)
• Similarity: 372/1039 - (35%)
• Gaps: 312/1039 - (30%)

  Fly   188 GRSALQPEIVEAIRSLDVPALR-------------LNNLSFDGSTDPKGERNHAEEEP--LTPGH 237
            |..|||..::.....:|:|.||             ::| :|....|.:| |...::.|  |.|..
 Frog    52 GSEALQDALLTLGSIIDIPRLRDAIRDAIASVLPKVDN-AFIYLLDAEG-RLVCDDPPHELPPEG 114

  Fly   238 DHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGKKNPPTEEEEFRTFQRNLMDLKYPTV 302
            ...|:|:|::::.|                       :|.  .|:|          |:..:..::
 Frog   115 KLRDAVLLQKRIEC-----------------------SGL--TPSE----------LLGQQMSSL 144

  Fly   303 LPPNPPLKALLVFHKSDS----ICEAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLII 363
            ..|.||.|.:|:....|.    :...|...|.:      |..|.|:.|.||:| :....|..::.
 Frog   145 AAPLPPDKQVLILPLLDQDTARVVSVILLHCSQ------LSDSDEQNLRTLEK-HTLVACKRVLA 202

  Fly   364 ID-ARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCVAETTNLAM 427
            |. .:.|..:....::   ..|:.:.|........:|:.|.|..::.|       | .|..:|..
 Frog   203 IQKLQPSPQVPPSPLS---PRTYQNSLPKPSPTANESYDELDRKILQL-------C-GELYDLDA 256

  Fly   428 CSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDD---LLRIQYANRATERLLNM---- 485
            .|:::|.|       |.:....|:....|      :|:::|   |.......:..|..::.
 Frog   257 ASLQIKVI-------HYLEQQTQSPCCCL------LLVSEDSHQLFCQVVGGKVLEEEISFPLTF 308

  Fly   486 -RLDEIISKQLEDIFVSDLSTISEQCKNIK-----EFDGILTV----RRKSQEGIPMHVRVVPVA 540
             .|.:::.|: :.|.:.|:|  ||:.:.:.     |...:|.|    |..||        ||.:|
 Frog   309 GHLGQVVDKK-KSITLQDIS--SEEHRQLNNMLGFEVHSMLCVPVISRATSQ--------VVALA 362

  Fly   541 CIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKL-- 603
            |.          |:..||:...:            ..|.::.|.....::.:..|......||
 Frog   363 CA----------FNKQGGKYTEV------------DEHKIQHCFCYTSTVLTSTLAFQKEQKLKC 405

  Fly   604 ------------------TSLPLEAPITKIINLLSQVQENCSA-----DEARLIDKVLEFLKREG 645
                              .|:.|:..||:..||.:  .|.||.     ....|:.||.:    .|
 Frog   406 ECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSN--AEICSVFLLERQSHELVAKVFD----GG 464

  Fly   646 LYSPQMKEIR--TDDPIATDL--IGALLTGPSVYSS---RRSSNDSIIRTGSSTRTAAIVPAKMK 703
            :...:..|||  .|..||..:  .|.:|.....||.   .|..:||   ||..||.....|.|.:
 Frog   465 VVDDESYEIRIPADQGIAGHVATTGQILNIKDAYSHPLFYRGVDDS---TGFRTRNILCFPIKNE 526

  Fly   704 SNPII--MELL-----------DESLSWDFDIFKLEEITDYHPLLY-----------LGMEM--- 741
            ||.:|  .||:           ||.|:..|.|:.  .|:..|.|||           |..||
 Frog   527 SNEVIGVAELVNKINGPGFTKFDEDLATAFSIYC--GISIAHSLLYKQVREAQFRSHLANEMMMY 589

  Fly   742 ----------------------------------------------FRRFDVFATLN---IDENV 757
                                                          ...|:....:|   ||...
 Frog   590 HMKVCEDETKKLQSNGIVSVCQIDPGFASFSYTPRSLPEDDTVMCVISMFEDMGFVNNYKIDRTT 654

  Fly   758 CKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRME--EATAL-IAAAAHD 819
            ...:..:::..|| ...|||..||..|     :....|..|::.:::.:|  |..|| ::...||
 Frog   655 LIRFCLMVKKGYR-DPPYHNWMHAFSV-----SHFCYLLFKNLELVNYLEYIEIFALFVSCLCHD 713

  Fly   820 VDHPGRSSAFLCNSNDALAVLY-NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTI 883
            :||.|.:::|...|...||.|| ::.:|:|.||.|....: |.....||.:...::.|:.....:
 Frog   714 LDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAI-LNSQGCNILEQFSRKDYQRMLDLM 777

  Fly   884 IDMILATEMTRH---FEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQF 945
            .|:||||::..|   |:.|.: :|..|.:....|:       ..|:..:|:..:|:|:..:..:.
 Frog   778 RDIILATDLAHHLRIFKELTR-MSQDGFDPQNKHH-------HYLLICLLMTSSDLSDQTKGWKT 834

  Fly   946 CIEWARRIAEEYFMQTDEEK-QRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWES-FIDM 1008
            ..:.|..|.:|:|.|.|.|| ..:.|  ..|.||....||:.||.|:|:|...:.:..:. |...
 Frog   835 TRKIAELIYKEFFSQGDLEKAMGNRP--SEMMDREKAYIPELQISFMEHIAMPIYNLLKDLFPRS 897

  Fly  1009 PQLITYMQINYSQWKK-----------------------------YDEQGVNTLAEIMAKQPPV 1043
            .:|...:..|..:|.:                             :||..:|..||....:.||
 Frog   898 AELYERVATNREKWTRVSHKFTIRGLPSNNSLDFLDEEYDIQEGLHDELRMNGCAETQGHREPV 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	NtrB	446..>539	CDD:443061	21/109 (19%)
		PDEase_I	775..1016	CDD:459723	68/249 (27%)
pde2a	XP_031751996.1	GAF	255..401	CDD:214500	33/191 (17%)
		GAF	423..574	CDD:214500	47/161 (29%)
		PDEase_I	671..904	CDD:459723	68/248 (27%)