Protein Alignment Pde8 and pde2a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_031751996.1
• Gene: pde2a / 780063
• XenbaseID: XB-GENE-5945995
• Length: 964
• Species: Xenopus tropicalis
• Alignment Length: 1034
• Identity: 215/1034 - (20%)
• Similarity: 372/1034 - (35%)
• Gaps: 302/1034 - (29%)

  Fly   188 GRSALQPEIVEAIRSLDVPALR-------------LNNLSFDGSTDPKGERNHAEEEP--LTPGH 237
            |..|||..::.....:|:|.||             ::| :|....|.:| |...::.|  |.|..
 Frog    52 GSEALQDALLTLGSIIDIPRLRDAIRDAIASVLPKVDN-AFIYLLDAEG-RLVCDDPPHELPPEG 114

  Fly   238 DHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGKKNPPTEEEEFRTFQRNLMDLKYPTV 302
            ...|:|:|::::.|                       :|.  .|:|          |:..:..::
 Frog   115 KLRDAVLLQKRIEC-----------------------SGL--TPSE----------LLGQQMSSL 144

  Fly   303 LPPNPPLKALLVFHKSDS----ICEAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLII 363
            ..|.||.|.:|:....|.    :...|...|.:      |..|.|:.|.||:| :....|..::.
 Frog   145 AAPLPPDKQVLILPLLDQDTARVVSVILLHCSQ------LSDSDEQNLRTLEK-HTLVACKRVLA 202

  Fly   364 ID-ARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCVAETTNLAM 427
            |. .:.|..:....::   ..|:.:.|........:|:.|.|..::.|       | .|..:|..
 Frog   203 IQKLQPSPQVPPSPLS---PRTYQNSLPKPSPTANESYDELDRKILQL-------C-GELYDLDA 256

  Fly   428 CSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDD---LLRIQYANRATERLLNM---- 485
            .|:::|.|       |.:....|:....|      :|:::|   |.......:..|..::.
 Frog   257 ASLQIKVI-------HYLEQQTQSPCCCL------LLVSEDSHQLFCQVVGGKVLEEEISFPLTF 308

  Fly   486 -RLDEIISKQLEDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVR----VVPVACIGSA 545
             .|.:::.|: :.|.:.|:|:     :..::.:.:|.....|...:|:..|    ||.:||.
 Frog   309 GHLGQVVDKK-KSITLQDISS-----EEHRQLNNMLGFEVHSMLCVPVISRATSQVVALACA--- 364

  Fly   546 PTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKL------- 603
                   |:..||:...:            ..|.::.|.....::.:..|......||
 Frog   365 -------FNKQGGKYTEV------------DEHKIQHCFCYTSTVLTSTLAFQKEQKLKCECQAL 410

  Fly   604 -------------TSLPLEAPITKIINLLSQVQENCSA-----DEARLIDKVLEFLKREGLYSPQ 650
                         .|:.|:..||:..||.:  .|.||.     ....|:.||.:    .|:...:
 Frog   411 LQVAKNLFTHLDDVSVLLQEIITEARNLSN--AEICSVFLLERQSHELVAKVFD----GGVVDDE 469

  Fly   651 MKEIR--TDDPIATDL--IGALLTGPSVYSS---RRSSNDSIIRTGSSTRTAAIVPAKMKSNPII 708
            ..|||  .|..||..:  .|.:|.....||.   .|..:||   ||..||.....|.|.:||.:|
 Frog   470 SYEIRIPADQGIAGHVATTGQILNIKDAYSHPLFYRGVDDS---TGFRTRNILCFPIKNESNEVI 531

  Fly   709 --MELL-----------DESLSWDFDIFKLEEITDYHPLLY-----------LGMEM-------- 741
              .||:           ||.|:..|.|:.  .|:..|.|||           |..||
 Frog   532 GVAELVNKINGPGFTKFDEDLATAFSIYC--GISIAHSLLYKQVREAQFRSHLANEMMMYHMKVC 594

  Fly   742 -----------------------------------------FRRFDVFATLN---IDENVCKAWL 762
                                                     ...|:....:|   ||......:.
 Frog   595 EDETKKLQSNGIVSVCQIDPGFASFSYTPRSLPEDDTVMCVISMFEDMGFVNNYKIDRTTLIRFC 659

  Fly   763 AVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRME--EATAL-IAAAAHDVDHPG 824
            .:::..|| ...|||..||..|     :....|..|::.:::.:|  |..|| ::...||:||.|
 Frog   660 LMVKKGYR-DPPYHNWMHAFSV-----SHFCYLLFKNLELVNYLEYIEIFALFVSCLCHDLDHRG 718

  Fly   825 RSSAFLCNSNDALAVLY-NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMIL 888
            .:::|...|...||.|| ::.:|:|.||.|....: |.....||.:...::.|:.....:.|:||
 Frog   719 TNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAI-LNSQGCNILEQFSRKDYQRMLDLMRDIIL 782

  Fly   889 ATEMTRH---FEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWA 950
            ||::..|   |:.|.: :|..|.:....|:       ..|:..:|:..:|:|:..:..:...:.|
 Frog   783 ATDLAHHLRIFKELTR-MSQDGFDPQNKHH-------HYLLICLLMTSSDLSDQTKGWKTTRKIA 839

  Fly   951 RRIAEEYFMQTDEEK-QRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWES-FIDMPQLIT 1013
            ..|.:|:|.|.|.|| ..:.|  ..|.||....||:.||.|:|:|...:.:..:. |....:|..
 Frog   840 ELIYKEFFSQGDLEKAMGNRP--SEMMDREKAYIPELQISFMEHIAMPIYNLLKDLFPRSAELYE 902

  Fly  1014 YMQINYSQWKK-----------------------------YDEQGVNTLAEIMAKQPPV 1043
            .:..|..:|.:                             :||..:|..||....:.||
 Frog   903 RVATNREKWTRVSHKFTIRGLPSNNSLDFLDEEYDIQEGLHDELRMNGCAETQGHREPV 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	15/91 (16%)
		PAS_9	463..539	CDD:290162	15/87 (17%)
		PDEase_I	775..1016	CDD:278654	68/249 (27%)
pde2a	XP_031751996.1	GAF	255..401	CDD:214500	29/186 (16%)
		GAF	423..574	CDD:214500	47/161 (29%)
		PDEase_I	671..904	CDD:395177	68/248 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010