DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and cdc27

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001072470.1	Gene:	cdc27 / 779925	XenbaseID:	XB-GENE-972658	Length:	832	Species:	Xenopus tropicalis

Alignment Length:	526	Identity:	101/526 - (19%)
Similarity:	174/526 - (33%)	Gaps:	171/526 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NCLPKFSKVFRRKSSAKSSSSSAGRENPSSEPDS---DTEPYAIAIAAISDRSGDNRNERPRPLP 64
            ||||....:     :..:.|....|     :||:   :|....|.:..::..|.:.:    .||.
Frog   178 NCLPNTCTM-----TVNTHSVVQHR-----QPDTVLMETPQDTIELNRLNLESSNMK----YPLN 228

  Fly    65 DDDSIRSRLISAAHLDLDVGLELASDSTAVPANGGIRPKSEGACPEMKVETISAATSPPPPRPLH 129
            .|.||       :::|..|   ::.||..:.....|..|             .|...|...|.|.
Frog   229 SDSSI-------SYIDPGV---ISPDSLPLGTGTSILSK-------------QAQNKPKTGRSLL 270

  Fly   130 GTSGPVAIS--LPFVGRNSSKTPEEMELEYEANVEAESRDIMT---PLRRNTRPLSVSFGGGGGR 189
            |  ||.|:|  .|..|....:||...:..|.....:...|:.:   |.:::...:|.:    |.:
Frog   271 G--GPAALSPLTPSFGILPLETPSPGDGSYLQTYSSCVLDVPSSGAPTKKSVARISQA----GTK 329

  Fly   190 SALQPEIVEAIRSLDV-PALRLNNLSFDGSTDPKGERNHAEEEPLTPGHDHEDSVVLRRKVNCLE 253
            |...    ::..|.|| |.|.:       .|...|.:.....:.|:|        .:....|.|.
Frog   330 SVFS----QSGNSRDVTPVLLV-------QTQGSGPQTSTTPQVLSP--------TIAAPPNALP 375

  Fly   254 RKAHSLYERRLPRVPKLHLLVAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKS 318
            |::..|:                ..:..|.:|..:.     :.:|:|   |..|..|.     ||
Frog   376 RRSSRLF----------------TSDSSTTKENSKK-----LKMKFP---PKMPNRKT-----KS 411

  Fly   319 DSICEAITAACQRHQLDVTLVKS-------------KEEALDTLQKSYATAQCYHLIIID----- 365
            .:....:|.|.....|:::.:.|             :.:|| |:||  |.|:....::.|
Frog   412 KTSKGGVTQANMNDSLEISKLDSSIISEGKISSVAPQIQAL-TIQK--AAAEGLMSLLRDMGKGY 473

  Fly   366 -ARSSKNLDAEHIARTIRHTHGHHLTTIIAVCK--KSFFEKDDVLIALLDAGVNRCVAETTNLAM 427
             |..|.|  .:.....:.|...||..|...:|:  :::||..:.|.|      .|..:|...:..
Frog   474 VALCSYN--CKEAINILSHLPSHHYNTGWVLCQIGRAYFELAEYLQA------ERVFSEVRRIES 530

  Fly   428 CSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIIS 492
            ..||..:|..:               |..|..|:|.|                        .::|
Frog   531 YRVEGMEIYST---------------TLWHLQKDVTL------------------------SVLS 556

  Fly   493 KQLEDI 498
            |.|.|:
Frog   557 KDLTDM 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	7/40 (18%)
		PAS_9	463..539	CDD:290162	5/36 (14%)
		PDEase_I	775..1016	CDD:278654
cdc27	NP_001072470.1	ANAPC3	17..92	CDD:372369
		TPR	501..762	CDD:223533	19/107 (18%)
		TPR repeat	501..527	CDD:276809	7/31 (23%)
		TPR repeat	567..595	CDD:276809
		TPR repeat	600..630	CDD:276809
		TPR repeat	635..663	CDD:276809
		TPR repeat	669..697	CDD:276809
		TPR repeat	703..731	CDD:276809
		TPR repeat	737..765	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165172329
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930