Protein Alignment Pde8 and Pde10a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_038945075.1
• Gene: Pde10a / 63885
• RGDID: 68434
• Length: 1075
• Species: Rattus norvegicus
• Alignment Length: 1222
• Identity: 238/1222 - (19%)
• Similarity: 393/1222 - (32%)
• Gaps: 457/1222 - (37%)

  Fly    42 AIAIAAISDRSGDNRNERPRPLPDDDSIRSRLIS-AAHLDLDVGLELASDSTAVPAN--GGIRPK 103
            |:.::...:..|..|.|...|.|     .||.:| |.|              |.||.  |.:...
  Rat    42 AVGLSLARELLGCGREELAAPPP-----LSRSLSPAGH--------------ASPAGGPGALSVL 87

  Fly   104 SEGACP------------EMKVETISAATS----PPPPRPLHGTSGPVAISLPFVGRNSS-KTPE 151
            |.|.|.            ...|.:.|.::|    ||||.|          ..|.|..:|: ..||
  Rat    88 SAGGCGWVAARAPWALAFSSPVPSSSFSSSWYFWPPPPLP----------PPPLVPSSSAFHLPE 142

  Fly   152 EMELEYEANVEA-----------------ESRDIMTPLRRNTRPLSVSFGGGGGRSALQPEIVEA 199
            .:.....|....                 |:..:..|...:.|....|.||.|||..|  .:..|
  Rat   143 RLPRREGAAAAGGGGGGGGGDAGGGGGGQEADPLSVPPGSSHRSGGGSSGGSGGRWRL--FLSPA 205

  Fly   200 IRSLDVPAL------------------RLNNLSFDGSTD------------------PKGER-NH 227
            |:.|.:||.                  |.::|.|.|:..                  |:|.. ..
  Rat   206 IQGLLLPARSGPRPPPPPRLPLHPGAHRADSLGFPGAGGGCPGLGPGSAAGGRTPWRPRGTALPL 270

  Fly   228 AEEEPLTPGHDHED-----SVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAG----------- 276
            |...||..|.|.||     :...||...|.  .:.||.:.::.....||..|..
  Rat   271 ATAWPLLFGSDMEDGPSNNASCFRRLTECF--LSPSLTDEKVKAYLSLHPQVLDEFVSESVSAET 333

  Fly   277 ------KKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLD 335
                  :||...|:|                   |:|.    .|....|:..:.:.     ::|:
  Rat   334 VEKWLKRKNNKAEDE-------------------PSPK----EVSRYQDTNMQGVV-----YELN 370

  Fly   336 VTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSF 400
            ..:    |:.|||...:       ||::                       :.|::||.:..|:
  Rat   371 SYI----EQRLDTGGDN-------HLLL-----------------------YELSSIIRIATKA- 400

  Fly   401 FEKDDVLIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQQAL------------- 452
               |...:..|    ..|     |.::|          :..|..:...|..|
  Rat   401 ---DGFALYFL----GEC-----NNSLC----------VFTPPGMKEGQPRLIPAGPITQGTTIS 443

  Fly   453 -YTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSDLSTISEQCKNIKEF 516
             |.|..|   ..|:.:|:|..:...|.|......|:..::.          |..::.    |.:.
  Rat   444 AYVAKSR---KTLLVEDILGDERFPRGTGLESGTRIQSVLC----------LPIVTA----IGDL 491

  Fly   517 DGILTV-RRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSV 580
            .|||.: |...:|...:..:.|..|.:..|..                            ::|.|
  Rat   492 IGILELYRHWGKEAFCLSHQEVATANLAWASV----------------------------AIHQV 528

  Fly   581 RRCSFDVRSIASDGLRRTSLAKLTSLP---LEAPITKIINLLSQVQENCSADEARLIDKVLEFL- 641
            :.|              ..|||.|.|.   |:...|...|:::             ||.:||.:
  Rat   529 QVC--------------RGLAKQTELNDFLLDVSKTYFDNIVA-------------IDSLLEHIM 566

  Fly   642 -------------------KREGLYS---------------PQMKEIR--TDDPIATDL--IGAL 668
                               |.:.|||               .:.||||  .:..||..:  .|.:
  Rat   567 IYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEV 631

  Fly   669 LTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPI-IMELL-----------DESLSWDFD 721
            |..|..|:..|.:.:..:.||.:||....:|...:.:.| :::::           ||:....|.
  Rat   632 LNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFA 696

  Fly   722 IF-----------------------KLEEITDYHP---------LLYLGM--------EMFRRFD 746
            :|                       .:|::: ||.         |::..:        |:| .||
  Rat   697 VFCALALHCANMYHRIRHSECIYRVTMEKLS-YHSICTSEEWQGLMHFNLPARICRDIELF-HFD 759

  Fly   747 VFATLNI-------------------DENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFI 792
            :....|:                   .|.:|: ::..::.:||:. .|||..||..|.....|.
  Rat   760 IGPFENMWPGIFVYMIHRSCGTSCFELEKLCR-FIMSVKKNYRRV-PYHNWKHAVTVAHCMYAI- 821

  Fly   793 TQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFK 857
              |.|.:.|..| :|....|||...||:||.|.|:::|...:..||.||:..| :|.||.:.|..
  Rat   822 --LQNNNGLFTD-LERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTST-MEQHHFSQTVS 882

  Fly   858 LTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEET 922
            : |..:..|||..|....|:.....|...|:||::..:|.:..:...::.......|| |:..:.
  Rat   883 I-LQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHN-QSHRDR 945

  Fly   923 SILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHL-PIVMPMFDR-ATCSIPK 985
            .|   .:::...|:.:..:........|..|..|::.:.||.|:..: ||  ||.|| ....:|:
  Rat   946 VI---GLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPI--PMMDRDKRDEVPQ 1005

  Fly   986 SQIGFIEYIIQDMMHAWESFIDMPQLITYMQI-------------NYSQWKK 1024
            .|:||.            :.:.:|...|..||             |.:||:|
  Rat  1006 GQLGFY------------NAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEK 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	14/80 (18%)
		PAS_9	463..539	CDD:290162	14/76 (18%)
		PDEase_I	775..1016	CDD:278654	65/242 (27%)
Pde10a	XP_038945075.1	GAF	382..525	CDD:396252	33/240 (14%)
		GAF	558..713	CDD:214500	29/154 (19%)
		PDEase_I	805..1037	CDD:395177	67/255 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920