Protein Alignment Pde8 and pde4a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_009298019.1
• Gene: pde4a / 572061
• ZFINID: ZDB-GENE-131125-7
• Length: 777
• Species: Danio rerio
• Alignment Length: 555
• Identity: 156/555 - (28%)
• Similarity: 251/555 - (45%)
• Gaps: 117/555 - (21%)

  Fly   567 PQPKEAPRGS-------LH-----SVRRCSFDVRSIASDGLRRTSLAKLTSLPLE--------AP 611
            |.|..:|..|       ||     |.||.||..||.:...:...::::.:|:..|        .|
Zfish   106 PSPGRSPMDSQASPGLVLHPSFPQSQRRESFLYRSDSDYDMSPKTMSRNSSINSEGHAEDLIVTP 170

  Fly   612 ITKIINLLSQVQENC---------------------SADEARLIDKVLEFLKREGLYS-----PQ 650
            ..:::..|..|:.|.                     :...|.|.|:..:.|.||.|..     .|
Zfish   171 FAQVLASLRTVRSNFTILANVTTPTTTMRSPVTSQPTVPPATLSDETYQQLARETLEELDWCLDQ 235

  Fly   651 MKEIRTD---DPIATDLIGALLTGPSVYSSRRSSNDSIIR------------------------- 687
            ::.|:|.   ..:|::....:|.....:.|..|.:.:.:.
Zfish   236 LETIQTHRSVSEMASNKFKRMLNRELSHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTLRERE 300

  Fly   688 ------------TGSSTRTAAIVP---AKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYL 737
                        |.||:.|:|.:|   .|.:....:...|::...|..:||.:.|.::..||..:
Zfish   301 KPMSHISGVKKLTHSSSLTSAALPRFGVKTEQEDALARELNDLNKWGLNIFHVAEFSNNRPLSCI 365

  Fly   738 GMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLV 802
            ...:|:..|:..|..|..:....::..:|.||..:..||||.|||||.|:|...::  |.....|
Zfish   366 MFAIFQERDLLKTFRIPVDTFITYVMTLEDHYHANVAYHNSLHAADVTQSTHVLLS--TPALDAV 428

  Fly   803 MDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINI 867
            ...:|...||.|||.|||||||.|:.||.|:|..||::|||.:||||||.|:.||| |.::..:|
Zfish   429 FSDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKL-LHEENCDI 492

  Fly   868 FKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETS--------- 923
            |:||.|...:|.|..:|||:|||:|::|...||...::.          :|.:.||
Zfish   493 FQNLTKRQRQSLRKLVIDMVLATDMSKHMSLLADLKTMV----------ETKKVTSSGVLMLDHY 547

  Fly   924 ---ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPK 985
               |.:.|.::..||:|||.:|:....:|..||.||:|.|.|:|::|.:.| .||.|:.|.|:.|
Zfish   548 NDRIQVLRNMVHCADLSNPTKPLAVYRQWTERIMEEFFQQGDKERERGMEI-SPMCDKHTASVEK 611

  Fly   986 SQIGFIEYIIQDMMHAWESFI--DMPQLITYMQIN 1018
            ||:|||:||:..:...|...:  |..:::..::.|
Zfish   612 SQVGFIDYIVHPLWETWGDLVHPDAQEILDTLEDN 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	101/254 (40%)
pde4a	XP_009298019.1	PDEase_I	403..644	CDD:278654	101/254 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850