DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and pde9ab

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_700447.5	Gene:	pde9ab / 571737	ZFINID:	ZDB-GENE-210629-1	Length:	518	Species:	Danio rerio

Alignment Length:	521	Identity:	144/521 - (27%)
Similarity:	237/521 - (45%)	Gaps:	102/521 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   581 RRCS-FDVRSI---ASDGLRRTSLAKLTS----------LPLEAP--ITKII------------- 616
            |.|| .|:|.:   :|:..|.|::..:.|          :|...|  :.|::
Zfish    28 RHCSPCDIRDLLCSSSNIARNTAVLLIDSEGALISIDPTMPANTPNNLYKVMSHSTNQGEEKEDM 92

  Fly   617 --NLLSQVQENCS------------ADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGA 667
              |:||||.|..:            .:...:::|.:|.   |||...::::.:.|   ...|...
Zfish    93 FQNVLSQVAEQFTRAFRISELKTEVTNRLAMLEKRVEL---EGLKVVEIEKCKND---LKKLKDE 151

  Fly   668 LLTGPSVYSSRRSSNDSIIRT--GSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLE--EI 728
            :.:|    |.|.:.|.....|  |........||...|.. :..|.:|......||::..|  |:
Zfish   152 MTSG----SMRVNCNCKYNFTDDGKKLSPRRDVPNYPKYT-LSQETIDALKKPTFDVWHWEHNEM 211

  Fly   729 TDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFI- 792
            ......:|..:.:.:.|      |::....|.||..|:.:|| .|.:||..|...|.|.....|
Zfish   212 LSCLEYMYHDLGLVKEF------NMNPITLKRWLLAIQENYR-DNPFHNFRHCFCVSQMMYGMIH 269

  Fly   793 -----TQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHA 852
                 .:||..||.::        :.||..||:||||.::.:..|:...|||.|||::.|||||.
Zfish   270 LCGLQDRLTMTDMCIL--------MTAAVCHDLDHPGYNNTYQINARTELAVRYNDISPLENHHC 326

  Fly   853 AITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQ 917
            |:.|:: |...:.|||.|::.|::|..|..||.:||||:|.:|.|.|..|      ::..|:...
Zfish   327 AVAFQI-LSMPECNIFANIEPESFKQIRQAIITLILATDMAKHGEILDSF------KQKVDNFDC 384

  Fly   918 TDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCS 982
            |:||....::.:|||..|:||..||.:....|...:.||||||:|.||...|| |.|..||...:
Zfish   385 TNEEHVKSLKMVLIKCCDISNEVRPTEVAEPWVDCLLEEYFMQSDREKSEGLP-VAPFMDRDKVT 448

  Fly   983 IPKSQIGFIEYIIQDMMHAWESFIDM-PQLITYM-------QINYSQWKKYDEQGVNTLAEIMAK 1039
            .|.:|||||::::..|   :|:.:.: ||:...|       :.:|.:.|:.::    .::|...|
Zfish   449 KPTAQIGFIKFVLIPM---FETVMKLFPQIEEIMVQPLRDSRDHYEELKQIED----AMSEAQKK 506

  Fly  1040 Q 1040
            :
Zfish   507 K 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	90/254 (35%)
pde9ab	XP_700447.5	PDEase_I	251..481	CDD:278654	90/248 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920