DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and pde4cb

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_021335380.1	Gene:	pde4cb / 571344	ZFINID:	ZDB-GENE-030131-4075	Length:	721	Species:	Danio rerio

Alignment Length:	572	Identity:	150/572 - (26%)
Similarity:	244/572 - (42%)	Gaps:	108/572 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   544 SAPTHLIFNFDVPGG-QMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLP 607
            |.|:.....|||..| .|...:..|.|........:|.||.||..||.:...|...::::.:|..
Zfish    61 SWPSSFHKRFDVENGLSMGRSSLDPSPSSGLVLQANSQRRESFLYRSDSDFDLSPKTMSRNSSTA 125

  Fly   608 LE--------APITKIINLLSQVQENCSA--------------------------DEA------- 631
            .|        .|..:::..|..|:.|.:|                          |||
Zfish   126 SELHGEDMIVTPFAQVLASLRTVRGNVAALTHMQDRSNKRPSGTNPQSACKTNLSDEAYQKLTVE 190

  Fly   632 ------------------------------RLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIG 666
                                          |::::.|..|........|:.|......:......
Zfish   191 TLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTQLSETSRSGNQVSEFIASTILQKQYDV 255

  Fly   667 ALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVP-------AKMKSNPIIMELLDESLSWDFDIFK 724
            .||:.......:|.....|......:.:.::.|       ...:...::.:.|::...|..||||
Zfish   256 ELLSAACKEEKKRRPMSQISGVRKLSPSPSLPPTCIPRFGVNTQHESLLAKELEDLDRWGIDIFK 320

  Fly   725 LEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATG 789
            :.|.:...||..:...:|:..|:..|..|..:....:|..:|.||.....|||:.|||||:|:|.
Zfish   321 IAEYSGNRPLTVMMYTIFQERDLLKTFKIPSDTFLTFLMTLEDHYHADVAYHNNIHAADVVQSTH 385

  Fly   790 AFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAI 854
            ..::....:|  |...:|...||.|:|.|||||||.::.||.|:|..||::|||.:||||||.|:
Zfish   386 VLLSTPALED--VFTDLEIMAALFASAIHDVDHPGVTNQFLINTNSELALMYNDASVLENHHLAV 448

  Fly   855 TFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTD 919
            .||| |.::..:||.||.|:..:|.|...|||:|||:|::|...||...::.          :|.
Zfish   449 GFKL-LQEENCDIFCNLSKKQRQSLRQMTIDMVLATDMSKHMNFLADLKTMV----------ETK 502

  Fly   920 EETS------------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIV 972
            :.||            |.:.:.::..||:|||.:|::...:|..||..|:|.|.|.|:.:.:. |
Zfish   503 KVTSQGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLELYRKWTDRIMVEFFSQGDRERDKGID-V 566

  Fly   973 MPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFI--DMPQLITYMQINYSQW 1022
            .||.|:.|.|:..:|:|||:|||..:...|...:  |...::..::.| .:|
Zfish   567 SPMCDKHTASMENTQVGFIDYIIHPLWETWADLVHPDAQDILDTLEDN-REW 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	94/254 (37%)
pde4cb	XP_021335380.1	PDEase_I	371..608	CDD:306695	94/250 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589324
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850