DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and pde8b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_009293455.1	Gene:	pde8b / 571011	ZFINID:	ZDB-GENE-091117-3	Length:	874	Species:	Danio rerio

Alignment Length:	793	Identity:	309/793 - (38%)
Similarity:	451/793 - (56%)	Gaps:	89/793 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 PLKALLVFHKSDSICEAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNL 372
            |::.||||.|.||..:|...||:|......:.::.|.||:.....:     :.::|||.|..:..
Zfish   111 PIQVLLVFAKEDSQSDAFWWACERAAFRCNIARTPESALECFLDKH-----HEIVIIDGRHPRYF 170

  Fly   373 DAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDD-VLIALLDAGVNRCVAETTNLAMCSVELKQIL 436
            :||.|.|.||.|.....|.|:||..::..:::: .::.||.||.:|...|.::::.|..||.|:.
Zfish   171 EAEAICRMIRATKLSEHTVILAVMPQTPSDQEEPSVLPLLSAGFSRRYLENSSVSACYNELIQLE 235

  Fly   437 HSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVS 501
            |..:|....:....|::|||.:.:|.|.|:.:...|||.|.|.|:::.....|:|.|:|.::..|
Zfish   236 HGEVRAQFKLRACNAVFTALEQCQEAVEISSEDHVIQYVNPAFEKMMGYHRGELIGKELTELPRS 300

  Fly   502 D------LSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQM 560
            |      |.||:...|..||:.||...||||.:.|..:|::.||  :|.            ||::
Zfish   301 DKNSADLLDTINTCIKKGKEWQGIYFSRRKSGDSIQQYVKITPV--VGQ------------GGKI 351

  Fly   561 DFIATLPQP------------KEAPRGSLHSVRRC-----------SFDVRSIAS--------DG 594
            ....::.:|            ||......||...|           |.|||||:|        ..
Zfish   352 RHFVSIKRPYSDNHRQVHKLSKEEKCCGEHSQSECNSLRHKDRRKESVDVRSISSHSSDAPSLQN 416

  Fly   595 LRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDP 659
            .|.:|:|::.|:.:||||||:||:::..||:.....|..:|:|||.|:...|||||:.. :.|||
Zfish   417 RRYSSMARIHSMTIEAPITKVINIINAAQESSPVTVAEALDRVLEILRTTELYSPQLAS-KEDDP 480

  Fly   660 IATDLIGALLTGPSVYSSRRSSNDSIIRTGSS----TRTAAIVPAKMKS-NPIIMELLDESLSWD 719
            ...||:|.|::.    ..||.|.:..|.:.|:    :::...||..:.. .|.|.|||:|...|:
Zfish   481 HTNDLVGGLMSD----GLRRLSGNEYIFSKSALQNMSQSQLGVPVPLNDIPPSIAELLNEEEQWE 541

  Fly   720 FDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADV 784
            |:|.:||..|...||.|||:::|..|.|...||..|:..:.||.|||.:|..||:||||||||||
Zfish   542 FNILELEAATHKRPLSYLGLKIFSAFGVCEFLNCSESTLRLWLQVIETNYHSSNSYHNSTHAADV 606

  Fly   785 MQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLEN 849
            :.||..|:.:...|..|  |:::|..||:||..||||||||:::||||:...||:||||..|||:
Zfish   607 LHATAYFLRKERVKASL--DQLDEVAALLAATVHDVDHPGRTNSFLCNAGSELAILYNDTAVLES 669

  Fly   850 HHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGG-----E 909
            ||||:.|:||:.|.|.|||||:::..:::.|..||||:|||||||||||:.|||:....     |
Zfish   670 HHAALAFQLTVRDSKCNIFKNMERTQFRTLRQAIIDMVLATEMTRHFEHVNKFVNSINKPMSAIE 734

  Fly   910 EPRDHNPQTD----------EETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEE 964
            |...::..:|          .|..:|::|||||.|||:||.||::.|||||.||:||||.|||||
Zfish   735 ETSSNSEGSDCEGQASIRNSPENRLLIKRMLIKCADVANPCRPLELCIEWAGRISEEYFAQTDEE 799

  Fly   965 KQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQINYSQWKKYDEQG 1029
            |::.||:|||:|||.|||||||||.||:|.|.||..||::|..:|.|:.::..||..||..||..
Zfish   800 KRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFASLPGLMEHLAENYKYWKNLDEMK 864

  Fly  1030 VNTLAEIMAKQPP 1042
            ..:|     :.||
Zfish   865 CKSL-----RPPP 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	29/85 (34%)
		PAS_9	463..539	CDD:290162	28/81 (35%)
		PDEase_I	775..1016	CDD:278654	137/255 (54%)
pde8b	XP_009293455.1	PDE8	1..47	CDD:285793
		TIM_phosphate_binding	<143..>212	CDD:304361	20/73 (27%)
		PAS_9	260..357	CDD:290162	34/110 (31%)
		PAS	264..357	CDD:238075	32/106 (30%)
		PDEase_I	597..850	CDD:278654	137/254 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589328
Domainoid	1	1.000	279	1.000	Domainoid score	I1674
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2758
Inparanoid	1	1.050	496	1.000	Inparanoid score	I1349
OMA	1	1.010	-	-		QHG50014
OrthoDB	1	1.010	-	-		D80286at33208
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm24749
orthoMCL	1	0.900	-	-		OOG6_105168
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	1	1.000	-	-		X2464
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940