Protein Alignment Pde8 and pde11al

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_697567.3
• Gene: pde11al / 569112
• ZFINID: ZDB-GENE-031118-106
• Length: 918
• Species: Danio rerio
• Alignment Length: 919
• Identity: 200/919 - (21%)
• Similarity: 327/919 - (35%)
• Gaps: 239/919 - (26%)

  Fly   208 LRLNNLSFDGSTDPKGERNHAEEEPLTPGHDHEDSVVLRRKVNCLERKAHS-----------LYE 261
            ||.|   |..|......|.:.|...||.   ||....:||:  .|.|||.|           |.|
Zfish    76 LRKN---FARSKAMTAHRTYDEHVSLTA---HESQSSMRRR--ALLRKASSLPPTTAHILSALLE 132

  Fly   262 RRLPRVPKLHLLVAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAIT 326
            .|: .||:........|....|..|...|...:.|:.....: .|...|.|:      ::|..:.
Zfish   133 SRV-NVPQYASSAIDYKYRLKESNEREFFLELVKDISNELDM-TNLSYKILI------NVCIMVN 189

  Fly   327 A-ACQ-------RHQ-------LDV---TLVKSKEEALDTLQ-----------------KSYATA 356
            | .|.       .|:       .||   |.|:.....||:.:                 ::..|.
Zfish   190 ADRCSLFLVEGPSHKRTLVSKFFDVHSGTTVRPSSSTLDSNEVQVPWGKGIIGYVAEHGETVNTP 254

  Fly   357 QCYHLIIIDARSSKNLD-------AEHIARTIRHTHGHHLTTIIAVCKK----SFFEKDDVLIAL 410
            ..|.    |.|.|..:|       ...:...||::.|..:..:.|:.|.    .|.|.|:.::.:
Zfish   255 NAYE----DHRFSDEIDKLTGYKTQSILCMAIRNSDGEVIGVVQAINKNPSGTPFTEDDEKVLQM 315

  Fly   411 LDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQ-- 473
            .             |..|.:.:...        .:.|..:..|.....|.|||   :||...|
Zfish   316 Y-------------LPFCGISISNA--------KLFSESRKEYERSRALLEVV---NDLFEEQTD 356

  Fly   474 ---YANRATERLLNMRLDEIIS-KQLEDI------FVSDLSTISEQCKNIKEFDGILTVRRKSQE 528
               ...:..:|.|.:...|..| ..||||      |......:|..|
Zfish   357 LEKIVRKIMQRALTLLQCERCSVLLLEDIHSPVVKFSQTFELMSPLC------------------ 403

  Fly   529 GIPMHVRVVPVAC----IGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRS 589
            .:...:.:..|:|    |.::...|:.:..:|....|..       :.||....:.:...|.:||
Zfish   404 SVDRDISMEKVSCSDWLINNSIAELVASTGLPVNISDVC-------QDPRFDAEADQASGFHIRS 461

  Fly   590 IASDGLRRTSLAKLTSLPLEAPI----------TKIINLLSQVQENCSADEARLIDKVLEF---- 640
            :                 |..||          .:|:|.|.:...| .||: ||.:..:.|
Zfish   462 V-----------------LCVPIWNRTHQIIGVAQILNRLDRKTFN-DADQ-RLFEAFVIFCGLG 507

  Fly   641 LKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSN 705
            :....:|: |:|:......:|.|::                  |...|.|......:..||:
Zfish   508 INNTMMYN-QVKKTWAKQSVALDML------------------SYHATCSKAEVDRLKAAKI--- 550

  Fly   706 PIIMEL-LDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHY 769
            |:..|| :||   :.|:.|.|    |...::...:.||....|.....||..|...||..:..:|
Zfish   551 PLSSELGIDE---FHFNDFSL----DNDAMITASLRMFLELGVVQKFKIDYEVLCRWLLTVRKNY 608

  Fly   770 RKSNTYHNSTHAADVMQ------ATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSA 828
            | :..|||..||.:|.|      .|.||...||..:.|.:        ::....||:||.|.::|
Zfish   609 R-TVAYHNWRHAFNVSQCMFIMITTAAFQEVLTETETLAL--------MVGCFCHDLDHRGTNNA 664

  Fly   829 FLCNSNDALAVLYNDLTVLENHH--AAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATE 891
            |...|..|||:||.....||:||  .|:   :.|..:..|||.||..:.|.:....:...||:|:
Zfish   665 FQAKSGSALALLYGTSATLEHHHFNHAV---MILQSEGHNIFANLCSKEYCNMMQLLKQAILSTD 726

  Fly   892 MTRHFEHLAKFVS-VFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAE 955
            :|.:|:....|.. |..|:     ...:|||...:.|.||:...|:....||.:...:.|..:..
Zfish   727 LTLYFKKRTTFFDCVLSGQ-----FSWSDEEHRDMFRSMLMTACDLGAVTRPWEISKQVAELVTS 786

  Fly   956 EYFMQTDEEKQRHLPIVMPMFDR-ATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQ----LITYM 1015
            |:|.|.|.|:.........:||| ....:|..|:.:|:.|.:.:   :|:.:.:.:    ::..:
Zfish   787 EFFEQGDRERSELKLTPAAIFDRNRKDELPVLQLEWIDGICKPL---YEALVKLNRKLQPMVDGI 848

  Fly  1016 QINYSQWKK 1024
            ..|..:|::
Zfish   849 DANRKKWEE 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	18/91 (20%)
		PAS_9	463..539	CDD:290162	15/87 (17%)
		PDEase_I	775..1016	CDD:278654	69/254 (27%)
pde11al	XP_697567.3	GAF	172..334	CDD:214500	30/193 (16%)
		GAF	356..518	CDD:214500	36/206 (17%)
		PDEase_I	613..849	CDD:278654	69/254 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850