Protein Alignment Pde8 and pde3a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_009298269.1
• Gene: pde3a / 567051
• ZFINID: ZDB-GENE-041210-23
• Length: 1124
• Species: Danio rerio
• Alignment Length: 558
• Identity: 148/558 - (26%)
• Similarity: 233/558 - (41%)
• Gaps: 131/558 - (23%)

  Fly   566 LPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADE 630
            ||.|:..|..|.|.              .|..:..|..:|..|..|.|.:.:       :|....
Zfish   496 LPDPELPPPRSPHK--------------ALTHSQSAPSSSAALWPPPTPLCS-------SCGRPY 539

  Fly   631 ARLIDKVLEFLKR--EGLYSPQMKEIRTDDPIATDLIGALLTG--PSVYSSRRSSNDSIIRTG-- 689
            ::         :|  :|...|..:..::|:|       |:::.  .|.|.:..|.:....:|.
Zfish   540 SK---------QRHSDGSTEPAERTQQSDEP-------AMMSSDYDSTYETNHSDSSDFAQTDED 588

  Fly   690 -SSTRT---AAIVPAKMK----SNPIIMELLDESL----SWDFDIFKLEEITDYHPLLYLGMEMF 742
             .:.||   |.::||:.|    ..|::||.|:..|    :|:|.||.|.|.|:......|....:
Zfish   589 REARRTLTLATLIPAEEKPILAPEPLLMEGLEPLLCQINNWNFPIFSLVEKTNGRCGCILSQMSY 653

  Fly   743 RRF---DVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQ---------- 794
            |.|   .:|.|..|.......:...:|..|| ...|||..||.||:.|.....||
Zfish   654 RLFVDTGLFETFKIPVREFMNYFHALENGYR-DIPYHNRIHATDVLHAVWYLTTQPVPGLPTLRT 717

  Fly   795 LTNKDM---LVMDRME------------------------EATAL-IAAAAHDVDHPGRSSAFLC 831
            |.:.|.   |...||:                        |..|| :|||.||.|||||::|||.
Zfish   718 LGSSDSDSGLAHGRMKYLMSRTNAVEEEGYGCLSGLIPALELMALYVAAAMHDYDHPGRTNAFLV 782

  Fly   832 NSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHF 896
            .::...||||||.:||||||||..:.|.:...:.|...:||...:|..|..:|:.||||::.:||
Zfish   783 ATSAPQAVLYNDRSVLENHHAASAWNLFMSRPEYNFLASLDHMEFKRFRFLVIEAILATDLKKHF 847

  Fly   897 EHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQT 961
            :.||:| :...|::.......|:|...:|:.:|.||:||::.|.:.....::|...|..|::.|.
Zfish   848 DFLAEF-NAKVGDDGCSGIDWTNENDRLLVCQMCIKLADINGPLKCKDLHLQWTEGIVNEFYEQG 911

  Fly   962 DEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQINYSQW---- 1022
            |||....||| .|..||:...:.|.|..||.:|:..:..:::|...||          .:|
Zfish   912 DEESSLGLPI-SPFMDRSAPQLAKLQESFITHIVGPLCSSYDSAALMP----------GRWVHPL 965

  Fly  1023 ------------------KKYDEQGVNTLAEIMAKQPP 1042
                              .:.:|:..:|.:|:..|..|
Zfish   966 PKDGDEVEDESEEEDEDTAEEEEEDASTSSELSQKPAP 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	92/278 (33%)
pde3a	XP_009298269.1	PDEase_I	688..947	CDD:278654	89/260 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850