Protein Alignment Pde8 and pde4ba

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_021332832.1
• Gene: pde4ba / 565706
• ZFINID: ZDB-GENE-030131-9570
• Length: 734
• Species: Danio rerio
• Alignment Length: 676
• Identity: 175/676 - (25%)
• Similarity: 280/676 - (41%)
• Gaps: 191/676 - (28%)

  Fly   458 RLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLE------DIFVSDLSTISEQCKNIKEF 516
            ||.|....:...|.:....|......|::|..:..:|:|      |.|::..:|:.
Zfish    23 RLSESFTSSGCTLGVDLRRRRRRFSGNLQLPPLSWRQMERSRSPDDEFMARPTTLP--------- 78

  Fly   517 DGILTVRRKSQEGIPMHVRVVPV--ACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSL-- 577
              .:|         |..:.:.||  .|           |||..|.....:.| .|:.:|...|
Zfish    79 --FIT---------PPRIDITPVDTEC-----------FDVENGPSASCSPL-DPQASPGSGLVL 120

  Fly   578 ------HSVRRCSFDVRSIASDGLRRTSLAKLTSLPLE--------APITKIINLLSQVQEN--- 625
                  |:.||.||..||.:...|...|:::.:|:..|        .|..:::..|..|:.|
Zfish   121 HTNFPGHNQRRESFLYRSDSDYDLSPKSMSRNSSVASELHGDDLIVTPFAQVLASLRSVRNNFTV 185

  Fly   626 -----------------------CSADEA------------------------------------ 631
                                   |..||:
Zfish   186 LTNVQCTSNKRSPVSNQPSITRVCLPDESYQKLAVETMEELDWCLDQLETIQTYRSVSDMASNKF 250

  Fly   632 -RLIDK--------------VLEFLKREGL----------YSPQMKEIRTDDPIATDLIGA--LL 669
             |::::              |.||:....|          .:|:.:|.:....:.|.:.|.  :.
Zfish   251 KRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQNDVEIPSPTPKAREKKKKQQLMTQISGVKKVS 315

  Fly   670 TGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPL 734
            .|||:       |..|.|.|          .|.....::.:.|::...|..:||.:.|.::..||
Zfish   316 HGPSL-------NCGIARFG----------VKTDKEDLLSKELEDLNRWGLNIFTVSEYSNNRPL 363

  Fly   735 LYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKD 799
            ..:...:|:..|:..|..|..:....::..:|.||.:...||||.|||||.|:|...::  |...
Zfish   364 TCIMYAIFQERDLLKTFKIPTDTFVTYMMTLEDHYHQDVAYHNSLHAADVAQSTHILLS--TPAL 426

  Fly   800 MLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDK 864
            ..|...:|...|:.|||.|||||||.|:.||.|:|..||::|||.:||||||.|:.||| |.:|.
Zfish   427 DAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKL-LQEDN 490

  Fly   865 INIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETS------ 923
            .:||:||.|:...|.|..:|||:|||:|::|...||...::.          :|.:.||
Zfish   491 CDIFQNLTKKQRTSLRRMVIDMVLATDMSKHMSLLADLKTMV----------ETKKVTSSGVLLL 545

  Fly   924 ------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCS 982
                  |.:.|.::..||:|||.:.::...:|..||.||:|.|.|.|::|.:.| .||.|:.|.|
Zfish   546 DNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFHQGDRERERGMEI-SPMCDKHTAS 609

  Fly   983 IPKSQIGFIEYIIQDMMHAWESFIDM 1008
            :.|||:|||:||:..:   ||::.|:
Zfish   610 VEKSQVGFIDYIVHPL---WETWADL 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	13/85 (15%)
		PAS_9	463..539	CDD:290162	11/81 (14%)
		PDEase_I	775..1016	CDD:278654	101/246 (41%)
pde4ba	XP_021332832.1	PDEase_I	404..641	CDD:306695	101/246 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920