Protein Alignment Pde8 and pde4ca

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_009296827.1
• Gene: pde4ca / 565259
• ZFINID: ZDB-GENE-070912-373
• Length: 742
• Species: Danio rerio
• Alignment Length: 556
• Identity: 156/556 - (28%)
• Similarity: 259/556 - (46%)
• Gaps: 96/556 - (17%)

  Fly   496 EDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRV---VPVACIGSAPTH-----LIFN 552
            ||:.|:..:.:....:.::....:||   ..|:.:|.....   .|..|..|.|..     .:..
Zfish   131 EDMIVTPFAQVLASLRTVRSNFAVLT---HQQDRVPSKKSTGNNPPSMCKTSLPEEPFQKLAVET 192

  Fly   553 FDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIIN 617
            .|.....::.:.||.        :.||       |..:||:..:|....:||.|   :..:|..|
Zfish   193 LDELDWCLEQLETLK--------TRHS-------VSEMASNKFKRMLNRELTQL---SETSKSGN 239

  Fly   618 LLSQVQENCSADEARLIDKVLEFLKREG----LYSPQMKEIRTDDPIATDLIGALLTGPSVYSSR 678
               ||.|..|:          .||:::.    :.:|..::.:...|::.      ::|  |....
Zfish   240 ---QVSEYISS----------TFLEKQHDMDIMSTPSKEKEKKKRPMSQ------ISG--VKKPT 283

  Fly   679 RSSN---DSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGME 740
            .|||   .||.|.|.||          ....::.:.|::...|..|:||:.|.:...||......
Zfish   284 HSSNIAPSSIPRFGVST----------NREDLLAKELEDFDRWGVDMFKISECSGNRPLTVAMYT 338

  Fly   741 MFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDR 805
            .|:..|:..:..|..:....::..:|.:||....||||.|||||:|:|...::  |.....|...
Zfish   339 TFQERDLLKSFKIPVDTFINYMTALEENYRSDVAYHNSIHAADVVQSTHVLLS--TPALEAVFTD 401

  Fly   806 MEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKN 870
            :|...|:.|:|.|||||||.|:.||.|:|..||::|||.:||||||.|:.||| |.::..:||:|
Zfish   402 LEILAAMFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQN 465

  Fly   871 LDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETS------------ 923
            |.|:..:|.|..:|||:|||:|::|...||...::.          :|.:.||
Zfish   466 LTKKQRQSLRKMVIDMVLATDMSKHMNLLADLKTMV----------ETKKVTSLGVLLLDNYSDR 520

  Fly   924 ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQI 988
            |.:.:.::..||:|||.:|::...:|..||..|:|.|.|.|:.:.:.| .||.|:...||.|||:
Zfish   521 IQVLQNMVHCADLSNPTKPLELYRQWTDRIMVEFFTQGDRERDKGMEI-SPMCDKHNASIEKSQV 584

  Fly   989 GFIEYIIQDMMHAWESFI--DMPQLITYMQINYSQW 1022
            |||:||:..:...|...:  |..:::..::.| .:|
Zfish   585 GFIDYIVHPLWETWADLVHPDAQEILDTLEDN-REW 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	7/45 (16%)
		PAS_9	463..539	CDD:290162	7/45 (16%)
		PDEase_I	775..1016	CDD:278654	96/254 (38%)
pde4ca	XP_009296827.1	PDEase_I	373..610	CDD:306695	96/250 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850