Protein Alignment Pde8 and pde4ca

DIOPT Version :10

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_073781958.1
• Gene: pde4ca / 565259
• ZFINID: ZDB-GENE-070912-373
• Length: 768
• Species: Danio rerio
• Alignment Length: 631
• Identity: 173/631 - (27%)
• Similarity: 264/631 - (41%)
• Gaps: 150/631 - (23%)

  Fly   514 KEFDGILTV----RRKSQEGIPMHVRVVPVACIG-----SAPTHLIFNFDVPGGQMDFIATLPQP 569
            :.|.|||.:    ||.|..|...........|||     .:.|....:|||..|..  :...|..
Zfish    43 RTFSGILQLPRLPRRLSAYGEYSSTTGKATFCIGLPNGLESDTPHGSSFDVENGLS--VGRSPLD 105

  Fly   570 KEAPRGS--------LHSVRRCSFDVRS-----IASDGLRRTS-------------------LAK 602
            .:|..||        .||.||.||..||     ::...:.|.|                   ||.
Zfish   106 SQASPGSGLVLQANFPHSQRRESFLYRSDSDFDLSPKAMSRNSSTASELHGEDMIVTPFAQVLAS 170

  Fly   603 L--------------------------------TSLPLEAPITKI-INLLSQ------------- 621
            |                                |||| |.|..|: :..|.:
Zfish   171 LRTVRSNFAVLTHQQDRVPSKKSTGNNPPSMCKTSLP-EEPFQKLAVETLDELDWCLEQLETLKT 234

  Fly   622 ---VQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPS---------- 673
               |.|..|....|::::.|..|........|:.|..:...:.......:::.||
Zfish   235 RHSVSEMASNKFKRMLNRELTQLSETSKSGNQVSEYISSTFLEKQHDMDIMSTPSKEKEKKKRPM 299

  Fly   674 -----VYSSRRSSN---DSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITD 730
                 |.....|||   .||.|.|.||          ....::.:.|::...|..|:||:.|.:.
Zfish   300 SQISGVKKPTHSSNIAPSSIPRFGVST----------NREDLLAKELEDFDRWGVDMFKISECSG 354

  Fly   731 YHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQL 795
            ..||.......|:..|:..:..|..:....::..:|.:||....||||.|||||:|:|...::
Zfish   355 NRPLTVAMYTTFQERDLLKSFKIPVDTFINYMTALEENYRSDVAYHNSIHAADVVQSTHVLLS-- 417

  Fly   796 TNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTL 860
            |.....|...:|...|:.|:|.|||||||.|:.||.|:|..||::|||.:||||||.|:.||| |
Zfish   418 TPALEAVFTDLEILAAMFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL-L 481

  Fly   861 GDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETS-- 923
            .::..:||:||.|:..:|.|..:|||:|||:|::|...||...::.          :|.:.||
Zfish   482 QEENCDIFQNLTKKQRQSLRKMVIDMVLATDMSKHMNLLADLKTMV----------ETKKVTSLG 536

  Fly   924 ----------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDR 978
                      |.:.:.::..||:|||.:|::...:|..||..|:|.|.|.|:.:.:.| .||.|:
Zfish   537 VLLLDNYSDRIQVLQNMVHCADLSNPTKPLELYRQWTDRIMVEFFTQGDRERDKGMEI-SPMCDK 600

  Fly   979 ATCSIPKSQIGFIEYIIQDMMHAWESFI--DMPQLITYMQINYSQW 1022
            ...||.|||:|||:||:..:...|...:  |..:::..::.| .:|
Zfish   601 HNASIEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDN-REW 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	NtrB	446..>539	CDD:443061	8/28 (29%)
		PDEase_I	775..1016	CDD:459723	96/254 (38%)
pde4ca	XP_073781958.1	None