DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and pde1a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_005167982.1	Gene:	pde1a / 564465	ZFINID:	ZDB-GENE-090831-2	Length:	611	Species:	Danio rerio

Alignment Length:	402	Identity:	116/402 - (28%)
Similarity:	200/402 - (49%)	Gaps:	44/402 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   615 IINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDD-PI-ATDLIGALLTGPSVYSS 677
            :::|...::...|..||..||:....|..|    .::.:|:.|. |: ..|.:.:..|.......
Zfish    57 VVDLRKNIEYAASVLEAVYIDETRRLLDTE----DELSDIQADSVPMEVRDWLASTFTRKMGVVR 117

  Fly   678 RRSSNDSIIRTGSSTRTAAIVPAKM---KSN-------PIIMELLDESLSWDFDIFKLEEITDYH 732
            ||.......|:......|.|...:|   .||       |.::..|.:...|.||:|||:|.:..|
Zfish   118 RRPEEKPRFRSIVHAVQAGIFVERMYRRTSNMAGLTYPPSVITALKDVDKWSFDVFKLQEASSDH 182

  Fly   733 PLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRK-SNTYHNSTHAADVMQA-------TG 789
            .|.:|..|:..|:|:.:...|..:...:::..:|..|.| .|.|||..|||||.|.       ||
Zfish   183 ALKFLVYELLTRYDLISRFRIPVSSLVSFVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTG 247

  Fly   790 AFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAI 854
            . :..||..::|.|        :.|||.||.:|.|.::.|...:...:|:||||.:||||||.:.
Zfish   248 V-MHWLTELEILAM--------VFAAAIHDFEHTGTTNNFHIQTRSEVAILYNDRSVLENHHVSA 303

  Fly   855 TFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTD 919
            .::| :.:|::||..||.|:.::..|:.:|:|:::|:|:.||:.:....:..       ..|:..
Zfish   304 AYRL-MQEDEMNILVNLSKDDWRELRTLVIEMVMSTDMSCHFQQIKTMRNSL-------QQPEGI 360

  Fly   920 EETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIP 984
            ::...|  .:::..||:|:||:..:....|.:.:.||:|.|.|:|.:..||. .|:.||....|.
Zfish   361 DKAKAL--SLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPF-SPLCDRKATMIA 422

  Fly   985 KSQIGFIEYIIQ 996
            :||||||::|::
Zfish   423 QSQIGFIDFIVE 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	75/229 (33%)
pde1a	XP_005167982.1	PDEase_I_N	85..141	CDD:285672	11/59 (19%)
pde1a	XP_005167982.1	PDEase_I	226..442	CDD:278654	75/229 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920