Protein Alignment Pde8 and pde3b

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_691883.4
• Gene: pde3b / 563432
• ZFINID: ZDB-GENE-160728-20
• Length: 1103
• Species: Danio rerio
• Alignment Length: 617
• Identity: 157/617 - (25%)
• Similarity: 252/617 - (40%)
• Gaps: 143/617 - (23%)

  Fly   501 SDLSTISEQCKNIKEFDGILTVRRKSQEGIPM---HV---------RVVPVACIGSAPTHLIFNF 553
            |:||:......|    ..:||:.::....:.:   |.         .:.||    ::|:|
Zfish   442 SELSSFVSNGPN----SNLLTIPKQRSSSVTLSYGHTLSRRPGASPSLSPV----TSPSH----- 493

  Fly   554 DVPGGQMDFIATLPQPKEAP-------RGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPL--- 608
            ..|.|....:.| ..|.|.|       :.|::..:...:.:.|.......|||    .|.||
Zfish   494 SPPAGPGSSLVT-RSPVEFPDTADFLTKPSVNLHKPLGYTMSSPDFQQQYRTS----ASTPLCTS 553

  Fly   609 -------EAPITKII----NLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIAT 662
                   ..|..:::    ...:::|...|||.|....   |.|.||.....:.:|.||.|
Zfish   554 CGRQMLKGVPSVEVVEGHHTTANEMQRTRSADGAEYGG---ENLIREESLEAESQEERTSD---- 611

  Fly   663 DLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVP---AKMKSNPIIM---ELLDESLSWDFD 721
                  ..|..|.|.......:     |||..:::.|   .:.:.:.:::   ||:::..:|:|.
Zfish   612 ------TAGEKVNSQPEEEEQT-----SSTEQSSLDPEGDEEFRLDLMLVEHEELMEKINTWNFQ 665

  Fly   722 IFKLEEITDYHP---LLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAAD 783
            ||:|.::|....   |.|:...:|:...:|....|.......:...:|..|| ...|||..||.|
Zfish   666 IFELMDLTGGKTGRILSYVAYTLFQDTGLFEIFKIPVREFMTYFCALENGYR-DIPYHNRVHATD 729

  Fly   784 VMQATGAFITQ-------------------------------LTNKDMLVMD-----------RM 806
            |:.|.....||                               .|:|.....|           .:
Zfish   730 VLHAVWYLTTQPIPGFQQIHNEHVTGSDTDSDSGISPGRVAYATSKSSSFQDDSYGCLAWNVPAL 794

  Fly   807 EEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNL 871
            |.....:|||.||.|||||::|||..:|...||||||.:||||||||..:.|.|...:.|...||
Zfish   795 ELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWSLFLSRPEFNFLCNL 859

  Fly   872 DKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQ----TDEETSILMRRMLIK 932
            |...:|..|..:|:.||||::.:||:.||:|.|     :..|.|..    |:|...:|:.::.||
Zfish   860 DHVEFKRFRFLVIEAILATDLKKHFDFLAEFNS-----KVNDVNSPGIDWTNENDRLLVCQVCIK 919

  Fly   933 VADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQD 997
            :||::.||:.....::|...|..|::.|.|||....||| .|..||:...:.|.|..||.:|:..
Zfish   920 LADINGPAKDRSLHLKWTEGIVNEFYEQGDEEGTLGLPI-SPFMDRSAPQLAKLQESFITHIVGP 983

  Fly   998 MMHAWESFIDMPQLITYMQINYSQWKKYDEQG 1029
            :.:::::...:|          ..|  .||:|
Zfish   984 LCNSYDAAGLLP----------GYW--IDEEG 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	7/49 (14%)
		PAS_9	463..539	CDD:290162	7/49 (14%)
		PDEase_I	775..1016	CDD:278654	91/286 (32%)
pde3b	XP_691883.4	PDEase_I	721..995	CDD:278654	90/279 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850