DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and si:dkey-219c10.4

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_017213373.2	Gene:	si:dkey-219c10.4 / 562357	ZFINID:	ZDB-GENE-081105-151	Length:	529	Species:	Danio rerio

Alignment Length:	498	Identity:	141/498 - (28%)
Similarity:	214/498 - (42%)	Gaps:	130/498 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   607 PLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREG---LYSPQMKEIRTDDP--------I 660
            |::.|...:.:|.....|....|       :|:....:|   ..|||   :.::.|        :
Zfish    20 PIDCPAQDVKDLFRAAAEAGPHD-------ILKLYNTKGNIINISPQ---LASNSPHSYYKLEVV 74

  Fly   661 ATD----LIG---ALLTGPSVYS--SRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLD--E 714
            |.|    |:|   |:..|..:.|  .|..|.:..|.| .:..|.|||....:......|.|:  |
Zfish    75 AADCNSELLGSELAVALGFDLTSMEKRLQSLEKRILT-EAAETPAIVYEMKRQVESFREKLESVE 138

  Fly   715 SLSWDFDIFK----------------------------------------LEEITDY-------- 731
            .||| ..:||                                        .||:..|
Zfish   139 HLSW-LGLFKDMSEGTHKPSPFYHKRTLRKTREECEHVREKFLQMSSLEVSEEVRQYLKTPTFDN 202

  Fly   732 -----HPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNT--YHNSTHAADVMQATG 789
                 ..::.|...|:...|..:|.||:.:|.:.:|..:   ||:.|.  :||..|...|.|...
Zfish   203 WQWEDAEIMVLLQVMYTDLDFISTFNIEPDVLQQFLYEV---YRRYNNIPFHNFKHCFCVTQMMY 264

  Fly   790 AFI--TQLTNK----DMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLE 848
            ..|  |.|.:|    |:|:|        |.:|..||:||.|.::|:..|:...||:.|||::.||
Zfish   265 GLIWLTDLRSKIDSIDLLIM--------LTSAVCHDLDHTGYNNAYQINARTELALRYNDISPLE 321

  Fly   849 NHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSV-----FGG 908
            |||.|:.|:: |...:.|||:||..|.||..|..||..||||:|:||.:.|.||.::     ||.
Zfish   322 NHHCAVAFEI-LEKTESNIFRNLPTEQYKRIREGIIKCILATDMSRHTDILNKFKAILPVFDFGN 385

  Fly   909 EEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVM 973
            ::.||          :|| .::|||:|:||.||||.....|...:.:|:|.|:|.||...|| |.
Zfish   386 KDHRD----------VLM-MIMIKVSDISNEARPMDVAEPWLDCLLQEFFNQSDMEKLEGLP-VT 438

  Fly   974 PMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQ 1016
            |..||...:.|.||.|||.:::      :..||::..|...::
Zfish   439 PFMDRDKVTKPSSQTGFIRFVL------FPLFIELANLFPCLE 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	93/251 (37%)
si:dkey-219c10.4	XP_017213373.2	PDEase_I	250..478	CDD:306695	93/253 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920