DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and pde6b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_685002.1	Gene:	pde6b / 559332	ZFINID:	ZDB-GENE-090421-2	Length:	854	Species:	Danio rerio

Alignment Length:	788	Identity:	161/788 - (20%)
Similarity:	299/788 - (37%)	Gaps:	154/788 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 LDVTLV------KSKEEALDTLQKS-----------YATAQCYHLIIIDARSSKNLDAEHIARTI 381
            ||:.:|      |.:....|..|.|           |.|   ::|:.....:.|::.|  :...:
Zfish   135 LDIGIVGHVAQTKKQVNVKDVTQDSHFSTFVDELTEYTT---HNLLAAPIMNGKDVVA--VIMAV 194

  Fly   382 RHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAG-VNRCVAETTNLAMCSVELKQILHSIIRPHNV 445
            ..|.|.|.|.          |..|:.:..|..| :|..:...:.|..|.....|:|
Zfish   195 NKTTGPHFTD----------EDMDLFLKYLKVGSLNLKIFHLSYLHNCETRKGQLL--------- 240

  Fly   446 MSTQQALYTALHRLKEVVLITDDLLRIQYANRA---TERLLNMRLDEIISKQLEDI--------- 498
                  |::|....:|:..|.....:..|..||   .:|.....||....|:..||
Zfish   241 ------LWSANKVFEELTDIERQFHKALYTVRAYLNCDRYSVGLLDMTKEKEFFDIWPVLMGEQP 299

  Fly   499 -FVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVP------VACIGSAPTHLIFNFDVP 556
             :...::....:....|..|.||..:.        .::|:|      .|.....||::
Zfish   300 PYSGPVTPDGREIIFYKVIDYILHGKE--------DIKVIPNPTADHWALASGLPTYV------- 349

  Fly   557 GGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLS- 620
             .:..||..:.        :..|.....|...::...|   .::..:.|||:.....:|:.:.:
Zfish   350 -AESGFICNIM--------NAASEEMFKFQTEALDDSG---WTIKNVLSLPIVNKKEEIVGVATF 402

  Fly   621 -QVQENCSADE--ARLIDKVLEFLKREGLYS---PQMKEIRTDDPIATDLIGALLTGPSVYSSRR 679
             ..::....||  .:|::.:.:||....|.:   .:|.::.....||.|::        :|..:
Zfish   403 YNRKDGKPFDEHDEQLMEALTQFLGWSALNTDTYDKMNKLENRKDIAQDMV--------LYHVK- 458

  Fly   680 SSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSW------------DFDIFKLEEITDYH 732
             ..|..|:....||.......:......::|:|.:.|..            |||..:|:
Zfish   459 -CRDDEIQDILKTREYFDREPRDCEEEELLEILKKELPGPKKFEIYAFHFSDFDCTELQ------ 516

  Fly   733 PLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTN 797
             |:..|::|:....|.....:.:.|...::..:...||:. ||||..|..:|.|.....:|  |.
Zfish   517 -LVMCGIQMYYEVGVVKKFQVPQEVLVRFMYSVSKGYRRI-TYHNWRHGFNVGQTMFTLLT--TG 577

  Fly   798 KDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITF-KLTLG 861
            |.......:|....:.|...||:||.|.::.:...|.:.||.|:.. ::||.||  :.| |..||
Zfish   578 KLKQYYTDLEVMAMITAGFLHDIDHRGTNNLYQVKSQNPLAKLHGS-SILERHH--LEFGKFLLG 639

  Fly   862 DDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSI-- 924
            ::.:|||:||::...:.....|...|:||::..:|:....|..:....|..:...:..:..|:
Zfish   640 EESLNIFQNLNRRQTEHVFHLIDIAIIATDLALYFKKRTMFQKIVDLSETYEERKKWIDFMSLET 704

  Fly   925 ----LMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQ--RHLPIVMPMFDR-ATCS 982
                ::..|::...|:|...:|.:...:.|..:|.|::.|.|.|:.  ...||  ||.|| ....
Zfish   705 TRKEIVMAMMMTACDLSAITKPWEVQSKVALSVAAEFWEQGDLERTVLEQQPI--PMMDRNKAAE 767

  Fly   983 IPKSQIGFIEYIIQDMMHAWESF-IDMPQLITYMQINYSQWKKYDEQ---GVNTLAE-IMAKQPP 1042
            :||.|.|||:::...:...:..| .::..:...:..|...||:..|:   .:..:.| :.|:|..
Zfish   768 LPKLQCGFIDFVCTFVYKEFSRFHPEIKPMFDGILNNRMHWKERQEEYEAKLKAMEEAVKARQEA 832

  Fly  1043 VGK-MANS 1049
            ..| .|||
Zfish   833 AAKNAANS 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	17/98 (17%)
		PAS_9	463..539	CDD:290162	16/94 (17%)
		PDEase_I	775..1016	CDD:278654	64/251 (25%)
pde6b	XP_685002.1	GAF	72..210	CDD:214500	18/89 (20%)
		GAF	253..440	CDD:214500	34/213 (16%)
		PDEase_I	557..801	CDD:278654	64/250 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589317
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850