Protein Alignment Pde8 and pde4bb

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_009296519.1
• Gene: pde4bb / 555599
• ZFINID: ZDB-GENE-070912-454
• Length: 707
• Species: Danio rerio
• Alignment Length: 562
• Identity: 152/562 - (27%)
• Similarity: 252/562 - (44%)
• Gaps: 115/562 - (20%)

  Fly   486 RLDEIISKQL--EDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTH 548
            |...::.:||  ||:.|:..:.:....:.::....|||                .|:|
Zfish   145 RNSSLVGEQLHGEDLIVTPFAQVLASLRTVRNNFSILT----------------NVSC------- 186

  Fly   549 LIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPIT 613
                              |..|.:|..|...|.:.     :::.:..::.:|..:..|.......
Zfish   187 ------------------PSSKRSPISSHGPVTKA-----NLSDESYQKLALETMEELDWCLDQL 228

  Fly   614 KIINLLSQVQENCSADEARLIDKVLEFL---KREG---------------------LYSPQMKE- 653
            :.|.....|.:..|....|::::.|..|   .|.|                     |.:|:.:|
Zfish   229 ETIQTYRSVSDMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQNELEIPLSTPKSRER 293

  Fly   654 IRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSW 718
            .:....:.|.:.|....   .:.|..||:.|..|.|          .|..|..::.:.|::...|
Zfish   294 KKRQQQLMTQISGVRKV---THGSGPSSSCSTTRFG----------VKTDSEDMLSKDLEDINKW 345

  Fly   719 DFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAAD 783
            ..:|||:.|.:.:.||..:...:|:..|:..|..|..:....::..:|.||.....||||.||||
Zfish   346 GLNIFKVAEHSHHRPLACIMYAIFQERDLMKTFKIPVDTFVTYMMTLEDHYHADVAYHNSLHAAD 410

  Fly   784 VMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLE 848
            |.|:|...::  |.....|...:|...||.|||.|||||||.|:.||.|:|..||::|||.:|||
Zfish   411 VAQSTHILLS--TPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLE 473

  Fly   849 NHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRD 913
            |||.|:.|||..|:: .::|:||.|:..::.|..:|.|:|||:|::|...||...::.
Zfish   474 NHHLAVGFKLLQGEN-CDLFQNLSKKERQTLRKMVIHMVLATDMSKHMSLLADLKTMV------- 530

  Fly   914 HNPQTDEETS------------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQ 966
               :|.:.||            |.:.|.::..||:|||.:|:....:|..||.:|:|.|.|.|::
Zfish   531 ---ETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKPLDLYKQWTDRIMQEFFHQGDRERE 592

  Fly   967 RHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDM 1008
            |.:.| .||.|:.|.|:.|||:|||:||:..:   ||::.|:
Zfish   593 RGMEI-SPMCDKHTASVEKSQVGFIDYIVHPL---WETWADL 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	9/54 (17%)
		PAS_9	463..539	CDD:290162	9/54 (17%)
		PDEase_I	775..1016	CDD:278654	98/246 (40%)
pde4bb	XP_009296519.1	PDEase_I	402..643	CDD:278654	98/246 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920