DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and 42Sp43

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001016094.1	Gene:	42Sp43 / 548848	XenbaseID:	XB-GENE-5898342	Length:	365	Species:	Xenopus tropicalis

Alignment Length:	294	Identity:	47/294 - (15%)
Similarity:	86/294 - (29%)	Gaps:	114/294 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 KAHSLYER--RLPRVPKLHLLVAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHK 317
            |:|:||:.  .||    |...|:|.|         |:|::                 |:.|..|.
Frog    93 KSHTLYKHGDALP----LKCSVSGCK---------RSFRK-----------------KSALRIHL 127

  Fly   318 SD------SICEAITAACQRHQLDVTLVKSKE----------EALDTLQKSYATAQCYHLIIIDA 366
            |:      |:|:  ...|.......|.:|:.:          |...|:..::...|
Frog   128 SEHSKESLSVCD--LPGCGWKSTSATELKAHQRRHGGYRCSHEGCQTISPTWTALQ--------- 181

  Fly   367 RSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSF------------FEKDDVLIALLDAGVNRCV 419
                           .|...|.|....|.|||.|            .:|..:.:.......::..
Frog   182 ---------------THLEKHPLELQCATCKKPFKKASALRRHKATHDKKPLKLPCPRQDCDKTF 231

  Fly   420 AETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLN 484
            ....||.          |.:.:.|..:.|.:..:...:|   ...:.:.|||....:....:.|.
Frog   232 NTVFNLT----------HHVRKVHLCLQTHRCYHAGCNR---SFAMRESLLRHLVVHDPERKKLK 283

  Fly   485 MRLDE---------------IISKQLEDIFVSDL 503
            ::|..               ::.:.|.::|...|
Frog   284 LKLGRRPPKFRGRGARCPTPVVEEDLTNLFSQKL 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	8/60 (13%)
		PAS_9	463..539	CDD:290162	8/56 (14%)
		PDEase_I	775..1016	CDD:278654
42Sp43	NP_001016094.1	C2H2 Zn finger	17..39	CDD:275368
		COG5048	<40..160	CDD:227381	21/98 (21%)
		C2H2 Zn finger	50..69	CDD:275368
		C2H2 Zn finger	77..100	CDD:275368	4/6 (67%)
		C2H2 Zn finger	108..130	CDD:275368	9/47 (19%)
		C2H2 Zn finger	138..160	CDD:275368	4/23 (17%)
		C2H2 Zn finger	193..213	CDD:275368	5/19 (26%)
		C2H2 Zn finger	222..245	CDD:275368	3/32 (9%)
		C2H2 Zn finger	253..275	CDD:275368	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165172330
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930