DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde3a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_061249.1	Gene:	Pde3a / 54611	MGIID:	1860764	Length:	1141	Species:	Mus musculus

Alignment Length:	761	Identity:	187/761 - (24%)
Similarity:	281/761 - (36%)	Gaps:	220/761 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 NVMSTQQALYTALH--RLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQL-EDIFVSDLST 505
            |::|| |..:.|:|  |:...|..:::     |....:|..|. :..:.|||:| ..:....|..
Mouse   376 NLLST-QLTFQAIHKPRVNPTVTFSEN-----YTCSDSEEGLE-KDKQAISKRLRRSLPPGLLRR 433

  Fly   506 ISEQCKNIKEFDGILT-----VRRKSQEGIPMHVRVVPVAC-----------------------I 542
            :|..........|:.|     |||.....|..|....|.|.                       .
Mouse   434 VSSTWTTTTSATGLPTLEPAPVRRDRSASIKPHEAPSPSAVNPDSWNAPGLTTLTKSRSFTSSYA 498

  Fly   543 GSAPTHL-IFNFDVPGGQMDFIATLPQPKEA-PRGSLHSVRRCSFDVRSIASD------------ 593
            .||..|: ....:.||| :..|:.:|.|..: |:||     ..|..|.:.||.
Mouse   499 VSAANHVKAKKQNRPGG-LAKISPVPSPSSSPPQGS-----PASSPVSNSASQQFPESPEVTIKR 557

  Fly   594 --GLRR--TSLAKLTSLPLEAPITKIINLLSQVQENCSA-----DEARLIDKVLEFLKREGLYSP 649
              |..|  |.......|..:.|...:|         ||:     .:....|...|   |.|   |
Mouse   558 GPGSHRALTYTQSAPDLSPQIPPPSVI---------CSSCGRPYSQGNPADGPSE---RSG---P 607

  Fly   650 QM-KEIRTDD--PIATDLIGALLTGPSVYSSRRSSNDSII------------------RTGSSTR 693
            .| |..||||  .:.:|           |.:..:|:.|.|                  ..|:.|.
Mouse   608 AMLKPNRTDDTSQVTSD-----------YETNNNSDSSDILQNEEEAECQREPQRKASACGTYTS 661

  Fly   694 TAAIVPAK--MKSNPIIME----LLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFD---VFA 749
            ...|...|  :...|::|:    ::|:..:|:|.||.|.|.........|....:|.|:   :|.
Mouse   662 QTMIFLDKPILAPEPLVMDNLDSIMDQLNTWNFPIFDLMENIGRKCGRILSQVSYRLFEDMGLFE 726

  Fly   750 TLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQ-------------------- 794
            ...|.......:...:|..|| ...|||..||.||:.|.....||
Mouse   727 AFKIPVREFMNYFHALEIGYR-DIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIGDHGSASDSDS 790

  Fly   795 ---LTNKDM-LVMDRME-----------------EATAL-IAAAAHDVDHPGRSSAFLCNSNDAL 837
               .|:..| .|..:|.                 |..|| :|||.||.|||||::|||..::...
Mouse   791 DSGFTHGHMGYVFSKMYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQ 855

  Fly   838 AVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKF 902
            ||||||.:||||||||..:.|.:...:.|...|||...:|..|..:|:.||||::.:||:.:|||
Mouse   856 AVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKF 920

  Fly   903 VSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQR 967
            .:....:...|   .|:|...:|:.:|.||:||::.||:..:..:.|...||.|::.|.|||...
Mouse   921 NAKVNDDVGID---WTNENDRLLVCQMCIKLADINGPAKCKELHLRWTEGIASEFYEQGDEEASL 982

  Fly   968 HLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMP----------------------- 1009
            .||| .|..||:...:...|..||.:|:..:.|:::|...||
Mouse   983 GLPI-SPFMDRSAPQLANLQESFISHIVGPLCHSYDSAGLMPGKWVDDSDDSGDTDDPEEEEEEA 1046

  Fly  1010 ---------------------------QLITYMQINYSQWKKYDEQ 1028
                                       |:..::..|:..|||..|:
Mouse  1047 ETPHEDEACESSIAPRKKSFKRRRIYCQITQHLLQNHMMWKKVIEE 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	17/85 (20%)
		PAS_9	463..539	CDD:290162	17/81 (21%)
		PDEase_I	775..1016	CDD:278654	95/332 (29%)
Pde3a	NP_061249.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..483		10/49 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..654		37/180 (21%)
		PDEase_I	751..1012	CDD:278654	90/264 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1060		0/35 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1120..1141
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844406
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850