DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and PDE6B

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_011511775.1	Gene:	PDE6B / 5158	HGNCID:	8786	Length:	941	Species:	Homo sapiens

Alignment Length:	892	Identity:	184/892 - (20%)
Similarity:	325/892 - (36%)	Gaps:	240/892 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 EEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQ-------RHQLDVTLVKS 341
            ||:.|:|            |..||.. |...|.|..| .|.:.|||:       ....|:..|:.
Human    78 EEQARSF------------LDQNPDF-ARQYFGKKLS-PENVAAACEDGCPPDCDSLRDLCQVEE 128

  Fly   342 KEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFF----- 401
            ....|:.:|              |.:.|.|:: ..:.:.:|     .|.|::...:.|.|
Human   129 STALLELVQ--------------DMQESINME-RVVFKVLR-----RLCTLLQADRCSLFMYRQR 173

  Fly   402 -------------EKDDVL-----------IALLDAGVNRCVAETTNLAMCSVELKQILHSIIRP 442
                         :.|.||           :..||.||...||:|..:    |.::.:...   |
Human   174 NGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKM----VNVEDVAEC---P 231

  Fly   443 H--------NVMSTQQALYTALHRLKEVVLI--------------TDDLLRIQYANRATERL--- 482
            |        ....|:..|.|.:...|:||.:              .|:.:.::|.|.||..|
Human   232 HFSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIY 296

  Fly   483 -------LNMRLDEIISKQLEDIFVSDLSTISEQCK----------NIKEFD-GILTVRRKSQEG 529
                   ...|..:::......:| .:|:.|..|..          |.:.:. |:|.:.::.:
Human   297 HLSYLHNCETRRGQVLLWSANKVF-EELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKE-- 358

  Fly   530 IPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGS--------------LHSV 580
                                  .|||    ...:....||...||..              ||..
Human   359 ----------------------FFDV----WSVLMGESQPYSGPRTPDGREIVFYKVIDYVLHGK 397

  Fly   581 RRCSFDVRSIASDGLRRTSLAK-LTSLPLEAP-ITKIINL----LSQVQENCSADEARLIDKVLE 639
            .    :::.|.:......:||. |.|...|:. |..|:|.    :.:.||....|...||..||.
Human   398 E----EIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLS 458

  Fly   640 ----------------FLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRS-------S 681
                            :.:::|....:..|:..:.  .|..:|..:.....|.....       :
Human   459 MPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES--LTQFLGWSVMNTDTYDKMNKLENRKDIA 521

  Fly   682 NDSIIRTGSSTR--TAAIVP--AKMKSNPI------IMELLDESL--SWDFDIFKLE----EITD 730
            .|.::......|  ...|:|  |::...|.      :.|:|.|.|  ...|||::..    |.|:
Human   522 QDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTE 586

  Fly   731 YHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQL 795
            . .|:..|::|:....|.....|.:.|...:|..|...||:. ||||..|..:|.|.  .|...:
Human   587 L-DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRI-TYHNWRHGFNVAQT--MFTLLM 647

  Fly   796 TNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITF-KLT 859
            |.|.......:|....:.|...||:||.|.::.:...|.:.||.|:.. ::||.||  :.| |..
Human   648 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGS-SILERHH--LEFGKFL 709

  Fly   860 LGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTD--EET 922
            |.::.:||::||::..::.....:...|:||::..:|:..|.|..:.  :|.:::..:..  |..
Human   710 LSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIV--DESKNYQDKKSWVEYL 772

  Fly   923 SI------LMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQ--RHLPIVMPMFDR- 978
            |:      ::..|::...|:|...:|.:...:.|..:|.|::.|.|.|:.  ...||  ||.||
Human   773 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPI--PMMDRN 835

  Fly   979 ATCSIPKSQIGFIEYIIQDMMHAWESFID--MPQLITYMQINYSQWK 1023
            ....:||.|:|||:::...:...:..|.:  :| :...:|.|..:||
Human   836 KAAELPKLQVGFIDFVCTFVYKEFSRFHEEILP-MFDRLQNNRKEWK 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	17/114 (15%)
		PAS_9	463..539	CDD:290162	15/110 (14%)
		PDEase_I	775..1016	CDD:278654	64/254 (25%)
PDE6B	XP_011511775.1	GAF	144..303	CDD:214500	31/171 (18%)
		GAF	325..512	CDD:214500	35/220 (16%)
		PDEase_I	629..874	CDD:278654	64/254 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154166
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850