DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and PDE1B

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_011536758.1	Gene:	PDE1B / 5153	HGNCID:	8775	Length:	537	Species:	Homo sapiens

Alignment Length:	520	Identity:	132/520 - (25%)
Similarity:	227/520 - (43%)	Gaps:	82/520 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   583 CSFDVRSIASDGLRRTSLAKLTSLP--------LEAPITKIINLLSQVQENCSADEARLIDKVLE 639
            ||.:..|:  |..|:.|:..|  :|        ||.....|..|...::...|..||..||:..:
Human    18 CSINYGSL--DLWRKRSVIFL--MPWLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQ 78

  Fly   640 FLKREGLYSPQMKEIRTD--DPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKM 702
            .|..|    .:::|:|:|  .....|.:.:..|..:....||:......|:......|.|...:|
Human    79 ILDTE----DELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERM 139

  Fly   703 ----------KSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENV 757
                      ..:..::..|.....|.||:|.|.:..|.|.|..:..|:..|.::.:...|....
Human   140 FRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVF 204

  Fly   758 CKAWLAVIEAHYRK-SNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVD 821
            ..::|..:|..|.| .|.|||..|||||.|....|:  |....:..:..:|....:.|||.||.:
Human   205 LMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFL--LRTGMVHCLSEIELLAIIFAAAIHDYE 267

  Fly   822 HPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDM 886
            |.|.:::|...:....|::|||.:||||||.:..|:| :.||::|||.||.|:.:...|:.:|:|
Human   268 HTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRL-MQDDEMNIFINLTKDEFVELRALVIEM 331

  Fly   887 ILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWAR 951
            :|||:|:.||:.:....:.....|      :.|:..::   .:|:..||:|:|.:.......|.:
Human   332 VLATDMSCHFQQVKTMKTALQQLE------RIDKPKAL---SLLLHAADISHPTKQWLVHSRWTK 387

  Fly   952 RIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHA--------------- 1001
            .:.||:|.|.|:|.:..||. .|:.||.:..:.:||||||::|::.....
Human   388 ALMEEFFRQGDKEAELGLPF-SPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADE 451

  Fly  1002 -----------W-ESFIDM------PQLITY-------MQINYSQWKKYDEQGVNTLAEIMAKQP 1041
                       | :..:|:      |.::::       :|.|..:||:....|:.....|....|
Human   452 DSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSP 516

Fly 1042 1041
Human 517 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	78/280 (28%)
PDE1B	XP_011536758.1	PDEase_I_N	82..138	CDD:285672	11/59 (19%)
PDE1B	XP_011536758.1	PDEase_I	223..450	CDD:278654	75/239 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920