DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and PDE8A

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_002596.1	Gene:	PDE8A / 5151	HGNCID:	8793	Length:	829	Species:	Homo sapiens

Alignment Length:	884	Identity:	321/884 - (36%)
Similarity:	478/884 - (54%)	Gaps:	101/884 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 IVEAIRSLDVPALRLNNLSFDGSTDPKGERNHAEEEPLTPGHDHEDSVVLRRKVNCLERKAHSLY 260
            |.|.:.:.|.|:.....||..|...|:|::..|
Human     9 ISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAA-------------------------------- 41

  Fly   261 ERRLPRVPKLHLLVAGKKNPPTEEEEFRTFQRN---LMDLKYPTVLPPNPPLKALLVFHKSDSIC 322
               |||.....||          |.|.|.....   :.|:::..:......|:.||||.|.|:.|
Human    42 ---LPRTRGAGLL----------ESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQC 93

  Fly   323 EAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGH 387
            .....||::.....|:.|..:..|......:     :.:||||.|:.:.||||.:.|:||.:...
Human    94 NGFCRACEKAGFKCTVTKEAQAVLACFLDKH-----HDIIIIDHRNPRQLDAEALCRSIRSSKLS 153

  Fly   388 HLTTIIAVCKKSFFEKDDVLIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQQAL 452
            ..|.|:.|.::...|:..|: ..:.||..|...|..|:..|..||.|:....:|....:....::
Human   154 ENTVIVGVVRRVDREELSVM-PFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSV 217

  Fly   453 YTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSD-----LSTISEQCKN 512
            :|||...::.:.||.:...|||||.|.|..:..:..|:|.|:|.::.:::     |.||:...:.
Human   218 FTALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRI 282

  Fly   513 IKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGG--QMDFIATLPQP---KEA 572
            .||:.||...::|:.:.|..:|:::||...|....|.:....|..|  :.:.|:...|.   .:.
Human   283 GKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDN 347

  Fly   573 PRGSLHSVRRCSFDVRSIASDGL------RRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEA 631
            ..|.....|:.|.||:::||...      |.:|:|::.|:.:||||||:||:::..||:......
Human   348 QTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVT 412

  Fly   632 RLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAA 696
            ..:|:|||.|:...|||||. ..:.|||.|.||:|.|:   |....|.|.|:.::.|.::...::
Human   413 EALDRVLEILRTTELYSPQF-GAKDDDPHANDLVGGLM---SDGLRRLSGNEYVLSTKNTQMVSS 473

  Fly   697 --IVPAKMKS-NPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVC 758
              |.|..:.. .|.|...::....||||||:||..|...||:|||::||.||.:...|:..|:..
Human   474 NIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTL 538

  Fly   759 KAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHP 823
            ::||.:|||:|..||.||||||:|||:.||..|:::...|:.|  |.::|..|||||..||||||
Human   539 RSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETL--DPIDEVAALIAATIHDVDHP 601

  Fly   824 GRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMIL 888
            ||:::||||:...||:||||..|||:||||:.|:||.||||.|||||:::..|::.|..||||:|
Human   602 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVL 666

  Fly   889 ATEMTRHFEHLAKFVSVFGGEEP---RDHNPQTDE------------ETSILMRRMLIKVADVSN 938
            |||||:||||:.|||:..  .:|   .:.|.:||:            |...|::|||||.|||||
Human   667 ATEMTKHFEHVNKFVNSI--NKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSN 729

  Fly   939 PARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWE 1003
            |.||:|:|||||.||:||||.|||||||:.||:|||:|||.|||||||||.||:|.|.||..||:
Human   730 PCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWD 794

  Fly  1004 SFIDMPQLITYMQINYSQWKKYDEQGVNTLAEIMAKQPP 1042
            :|:|:|.|:.::..|:..||..||..:..|     :.||
Human   795 AFVDLPDLMQHLDNNFKYWKGLDEMKLRNL-----RPPP 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	23/84 (27%)
		PAS_9	463..539	CDD:290162	23/80 (29%)
		PDEase_I	775..1016	CDD:278654	144/255 (56%)
PDE8A	NP_002596.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..46		11/64 (17%)
		OmpR	82..>159	CDD:223816	25/81 (31%)
		REC	83..>170	CDD:302758	28/91 (31%)
		PAS_9	226..324	CDD:290162	27/97 (28%)
		PAS	230..324	CDD:238075	27/93 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..360		2/18 (11%)
		Involved in RAF1-binding. /evidence=ECO:0000269\|PubMed:23509299	454..461		3/6 (50%)
		PDEase_I	555..807	CDD:278654	144/255 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154147
Domainoid	1	1.000	294	1.000	Domainoid score	I1494
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	536	1.000	Inparanoid score	I1203
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50014
OrthoDB	1	1.010	-	-		D80286at33208
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm40315
orthoMCL	1	0.900	-	-		OOG6_105168
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	1	1.000	-	-		X2464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940