DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and PDE7A

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001229247.1	Gene:	PDE7A / 5150	HGNCID:	8791	Length:	482	Species:	Homo sapiens

Alignment Length:	329	Identity:	106/329 - (32%)
Similarity:	176/329 - (53%)	Gaps:	39/329 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   711 LLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTY 775
            :|::..:|:||||..:.:|:.:.|:.|...:|....:....::|....:.:|.:|:..|...|.|
Human   147 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPY 211

  Fly   776 HNSTHAADVMQATGAFITQ------LTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSN 834
            ||:.|||||.||...::.:      :|..|:|:        :|||||.||:||||.:..||..:|
Human   212 HNAVHAADVTQAMHCYLKEPKLANSVTPWDILL--------SLIAAATHDLDHPGVNQPFLIKTN 268

  Fly   835 DALAVLYNDLTVLENHH--AAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFE 897
            ..||.||.:.:||||||  :|:......|     :|.:|..|:.:...:.|..:||||:::|..|
Human   269 HYLATLYKNTSVLENHHWRSAVGLLRESG-----LFSHLPLESRQQMETQIGALILATDISRQNE 328

  Fly   898 HLAKFVSVFGGEEPRDHNPQTD---EET--SILMRRMLIKVADVSNPARPMQFCIEWARRIAEEY 957
            :|:.|         |.|..:.|   |:|  ..|:.:|.:|.||:.||.|..:...:|:.::.||:
Human   329 YLSLF---------RSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEF 384

  Fly   958 FMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFID---MPQLITYMQINY 1019
            |.|.|.||:.||. |.|:.||.|.||...||||:.|:::.:...|..|.:   ...::.::.:|.
Human   385 FHQGDIEKKYHLG-VSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNK 448

  Fly  1020 SQWK 1023
            :.||
Human   449 ASWK 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	88/256 (34%)
PDE7A	NP_001229247.1	PDEase_I	211..444	CDD:395177	88/255 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154170
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850