DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and PDE6A

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_000431.2	Gene:	PDE6A / 5145	HGNCID:	8785	Length:	860	Species:	Homo sapiens

Alignment Length:	868	Identity:	180/868 - (20%)
Similarity:	314/868 - (36%)	Gaps:	221/868 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 NPPTEEEE------FRTFQRNLMD-------LKYPTVLPPNPPLKA----LLVFHKSDSICEAIT 326
            :|.:.||.      .|.||.||..       :|....|     |:|    |.::...:.|.|..|
Human    51 SPSSMEESEIIFDLLRDFQENLQTEKCIFNVMKKLCFL-----LQADRMSLFMYRTRNGIAELAT 110

  Fly   327 AACQRHQ---LDVTLVKSKEEALDTL----------QKSYATAQ--------CYHLIIIDARSSK 370
            .....|:   |:..||...:|.:..|          .|..|...        |..:.|:....:|
Human   111 RLFNVHKDAVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTK 175

  Fly   371 NLDAEHIARTIRHTHGHHLTTIIAVCKK---SFFEK--DDVLIALLD-AGVNRCVAETTNLAMCS 429
            |:.|..|      .:|..:..||....|   |.|.|  :::|:..|: |.:...|...:.|..|.
Human   176 NILASPI------MNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCE 234

  Fly   430 VELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRA---TERLLNMRLDEII 491
            ....|||               |::.....:|:..|.....:..|..||   .:|.....||...
Human   235 TRRGQIL---------------LWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTK 284

  Fly   492 SKQLEDIFVSDLSTI----------SEQCKNIKEFDGILTVRRKSQ-------------EGIPMH 533
            .|:..|::...:..:          ..:....|..|.||..:...:             .|:|.:
Human   285 QKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAY 349

  Fly   534 VRVVPVAC-IGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRR 597
            |....:.| |.:||....|.|.               ||
Human   350 VAQNGLICNIMNAPAEDFFAFQ---------------KE-------------------------- 373

  Fly   598 TSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIAT 662
                     ||:.....|.|:||....|   .:..::.....:.:::|....:|.|...:.  .|
Human   374 ---------PLDESGWMIKNVLSMPIVN---KKEEIVGVATFYNRKDGKPFDEMDETLMES--LT 424

  Fly   663 DLIGALLTGPSVYSSR------------------RSSNDSIIRTGSSTRTAAIVPAKMKSNPIIM 709
            ..:|..:..|..|.|.                  :..|:.|.:...:.......|.:.:... :.
Human   425 QFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEE-LA 488

  Fly   710 ELLDESLSWDFDIFKLEEITDYH----PLLYL-----GMEMFRRFDVFATLNIDENVCKAWLAVI 765
            |:|...|. |.|.:   ||..:|    ||..|     |::|:....|....:|.:.....::..:
Human   489 EILQAELP-DADKY---EINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSL 549

  Fly   766 EAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRME------EATALIAAA-AHDVDHP 823
            ...|||. ||||..|..:|.|         |...:||..:::      ||.|::.|| .||:||.
Human   550 SKGYRKI-TYHNWRHGFNVGQ---------TMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHR 604

  Fly   824 GRSSAFLCNSNDALAVLYNDLTVLENHHAAITF-KLTLGDDKINIFKNLDKETYKSARSTIIDMI 887
            |.::.:...|.:.||.|:.. ::||.||  :.| |..|.|:.:|||:||::..::.|...:...|
Human   605 GTNNLYQMKSQNPLAKLHGS-SILERHH--LEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAI 666

  Fly   888 LATEMTRHFEHLAKFVSV------FGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFC 946
            :||::..:|:....|..:      :..|:........::....::..|::...|:|...:|.:..
Human   667 IATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQ 731

  Fly   947 IEWARRIAEEYFMQTDEEKQ--RHLPIVMPMFDRATC-SIPKSQIGFIEYIIQDMMHAWESF-ID 1007
            .:.|..:|.|::.|.|.|:.  :..||  ||.||... .:||.|:|||:::...:...:..| .:
Human   732 SQVALLVAAEFWEQGDLERTVLQQNPI--PMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEE 794

  Fly  1008 MPQLITYMQINYSQWK----KYD 1026
            :..::..:..|..:||    :||
Human   795 ITPMLDGITNNRKEWKALADEYD 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	17/105 (16%)
		PAS_9	463..539	CDD:290162	16/101 (16%)
		PDEase_I	775..1016	CDD:278654	66/258 (26%)
PDE6A	NP_000431.2	GAF	75..232	CDD:214500	34/167 (20%)
		GAF	254..441	CDD:214500	39/241 (16%)
		PDEase_I	558..802	CDD:365964	66/257 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..860
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154167
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850