Protein Alignment Pde8 and PDE4D

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_001098101.1
• Gene: PDE4D / 5144
• HGNCID: 8783
• Length: 809
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 164/585 - (28%)
• Similarity: 253/585 - (43%)
• Gaps: 145/585 - (24%)

  Fly   553 FDVPGGQMDFIATLPQPKEAPRGSL-------HSVRRCSFDVR----------------SIASD- 593
            |||..|.....:.| .|..:|...|       ||.||.||..|                |||||
Human   153 FDVDNGTSAGRSPL-DPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDI 216

  Fly   594 ---------------GLR--RTSLAKLTSLPLEAP----------------ITK----------- 614
                           .||  |.:.|.||:|...||                ||:
Human   217 HGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETL 281

  Fly   615 -----IINLLSQVQENCSADE------ARLIDKVLEFL---KREG-------------------L 646
                 .::.|..:|...|..|      .|::::.|..|   .|.|                   :
Human   282 EELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEI 346

  Fly   647 YSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMEL 711
            .||..||........:.:.|.    ..:..|...:|.||.|.|          .|.:...::.:.
Human   347 PSPTQKEKEKKKRPMSQISGV----KKLMHSSSLTNSSIPRFG----------VKTEQEDVLAKE 397

  Fly   712 LDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYH 776
            |::...|...:|::.|::...||..:...:|:..|:..|..|..:....:|..:|.||.....||
Human   398 LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH 462

  Fly   777 NSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLY 841
            |:.|||||:|:|...::  |.....|...:|...|:.|:|.|||||||.|:.||.|:|..||::|
Human   463 NNIHAADVVQSTHVLLS--TPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMY 525

  Fly   842 NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVF 906
            ||.:||||||.|:.||| |.::..:||:||.|:..:|.|..:||::|||:|::|...||...::.
Human   526 NDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMV 589

  Fly   907 GGEEPRDHNPQTDEETS------------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFM 959
                      :|.:.||            |.:.:.::..||:|||.:|:|...:|..||.||:|.
Human   590 ----------ETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFR 644

  Fly   960 QTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFI--DMPQLITYMQINYSQW 1022
            |.|.|::|.:.| .||.|:...|:.|||:|||:||:..:...|...:  |...::..::.| .:|
Human   645 QGDRERERGMEI-SPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDN-REW 707

  Fly  1023  1022
            Human   708  707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	96/254 (38%)
PDE4D	NP_001098101.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..107
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..364		4/20 (20%)
		PDEase_I	461..702	CDD:278654	96/254 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	710..729
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	739..809

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154173
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850