DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde8 and PDE4C

DIOPT Version :10

Sequence 1:NP_001163275.2 Gene:Pde8 / 37741 FlyBaseID:FBgn0266377 Length:1050 Species:Drosophila melanogaster
Sequence 2:NP_000914.2 Gene:PDE4C / 5143 HGNCID:8782 Length:712 Species:Homo sapiens


Alignment Length:548 Identity:149/548 - (27%)
Similarity:254/548 - (46%) Gaps:83/548 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   496 EDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQM 560
            ||:.|:..:.:....:.::  ..:..:.|:.              |:|:|.       ..|.|..
Human   148 EDMIVTPFAQVLASLRTVR--SNVAALARQQ--------------CLGAAK-------QGPVGNP 189

  Fly   561 DFIATLPQPKEAPR----GSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQ 621
            .....||..::..:    .:|..:..|...:.::.:    |.|:.::.|...:..:.:.:..||:
Human   190 SSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQT----RHSVGEMASNKFKRILNRELTHLSE 250

  Fly   622 VQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSII 686
            .        :|..::|.|::.|  .:..|..|:......|.:....:        ||.|....:.
Human   251 T--------SRSGNQVSEYISR--TFLDQQTEVELPKVTAEEAPQPM--------SRISGLHGLC 297

  Fly   687 RTGSSTRTAAIVP---AKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVF 748
            .  |::.::|.||   .:......:.:.|:::..|..|:||:.|::...||..:...:|:..|:.
Human   298 H--SASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL 360

  Fly   749 ATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALI 813
            .|..|..:....:|.::|.||..:..||||.|||||.|:|...:.  |.....|...:|...||.
Human   361 KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLA--TPALEAVFTDLEILAALF 423

  Fly   814 AAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKS 878
            |:|.|||||||.|:.||.|:|..||::|||.:||||||.|:.||| |..:..:||:||..:...|
Human   424 ASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLS 487

  Fly   879 ARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETS------------ILMRRMLI 931
            .|..:|||:|||:|::|...||...::.          :|.:.||            |.:.:.|:
Human   488 LRRMVIDMVLATDMSKHMNLLADLKTMV----------ETKKVTSLGVLLLDNYSDRIQVLQNLV 542

  Fly   932 KVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQ 996
            ..||:|||.:|:....:|..||..|:|.|.|.|::..|.| .||.|:.|.|:.|||:|||:||..
Human   543 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDI-SPMCDKHTASVEKSQVGFIDYIAH 606

  Fly   997 DMMHAWESFI--DMPQLITYMQINYSQW 1022
            .:...|...:  |...|:..::.| .:|
Human   607 PLWETWADLVHPDAQDLLDTLEDN-REW 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde8NP_001163275.2 NtrB 446..>539 CDD:443061 4/42 (10%)
PDEase_I 775..1016 CDD:459723 99/254 (39%)
PDE4CNP_000914.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 45..64
PDE4_UCR 152..268 CDD:465648 20/152 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 181..200 5/25 (20%)
PDEase_I 387..627 CDD:459723 99/253 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 636..655
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 664..712
Blue background indicates that the domain is not in the aligned region.

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