Protein Alignment Pde8 and PDE4C

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_000914.2
• Gene: PDE4C / 5143
• HGNCID: 8782
• Length: 712
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 149/548 - (27%)
• Similarity: 254/548 - (46%)
• Gaps: 83/548 - (15%)

  Fly   496 EDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQM 560
            ||:.|:..:.:....:.::  ..:..:.|:.              |:|:|.       ..|.|..
Human   148 EDMIVTPFAQVLASLRTVR--SNVAALARQQ--------------CLGAAK-------QGPVGNP 189

  Fly   561 DFIATLPQPKEAPR----GSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQ 621
            .....||..::..:    .:|..:..|...:.::.:    |.|:.::.|...:..:.:.:..||:
Human   190 SSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQT----RHSVGEMASNKFKRILNRELTHLSE 250

  Fly   622 VQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSII 686
            .        :|..::|.|::.|  .:..|..|:......|.:....:        ||.|....:.
Human   251 T--------SRSGNQVSEYISR--TFLDQQTEVELPKVTAEEAPQPM--------SRISGLHGLC 297

  Fly   687 RTGSSTRTAAIVP---AKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVF 748
            .  |::.::|.||   .:......:.:.|:::..|..|:||:.|::...||..:...:|:..|:.
Human   298 H--SASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL 360

  Fly   749 ATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALI 813
            .|..|..:....:|.::|.||..:..||||.|||||.|:|...:.  |.....|...:|...||.
Human   361 KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLA--TPALEAVFTDLEILAALF 423

  Fly   814 AAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKS 878
            |:|.|||||||.|:.||.|:|..||::|||.:||||||.|:.||| |..:..:||:||..:...|
Human   424 ASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLS 487

  Fly   879 ARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETS------------ILMRRMLI 931
            .|..:|||:|||:|::|...||...::.          :|.:.||            |.:.:.|:
Human   488 LRRMVIDMVLATDMSKHMNLLADLKTMV----------ETKKVTSLGVLLLDNYSDRIQVLQNLV 542

  Fly   932 KVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQ 996
            ..||:|||.:|:....:|..||..|:|.|.|.|::..|.| .||.|:.|.|:.|||:|||:||..
Human   543 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDI-SPMCDKHTASVEKSQVGFIDYIAH 606

  Fly   997 DMMHAWESFI--DMPQLITYMQINYSQW 1022
            .:...|...:  |...|:..::.| .:|
Human   607 PLWETWADLVHPDAQDLLDTLEDN-REW 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	4/42 (10%)
		PAS_9	463..539	CDD:290162	4/42 (10%)
		PDEase_I	775..1016	CDD:278654	99/254 (39%)
PDE4C	NP_000914.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..64
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..200		5/25 (20%)
		PDEase_I	387..628	CDD:278654	99/254 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..655
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	664..712

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850